CARBOXYLESTERASE

作品数：38被引量：81H指数：5
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相关领域：农业科学更多>>
相关作者：薛丽周正堂高希武卢延宋敦伦更多>>
相关机构：中国农业大学上海交通大学华东理工大学更多>>
相关期刊：《Journal of Biomedical Research》《Studies in Fungi》《Journal of Clinical and Translational Hepatology》《Oncology Research》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划转基因生物新品种培育专项湖北省自然科学基金更多>>
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Engineering high-performance chemiluminescent probes via enzymatic pocket targeting:high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma
《Science China Chemistry》2025年第3期1175-1184,共10页Shuai Huang Shuaige Bai Ting Luo Bin Feng Min Liu Fan Zheng Shuang Huang Yanpeng Fang Dan Ding Wenbin Zeng 
supported by the National Natural Science Foundation of China (82272067,22107123,and M-0696);the Natural Science Foundation of Hunan Province (2022JJ80052)。
Hepatocellular carcinoma(HCC)is a highly aggressive liver malignancy and the main form of liver cancer.Early diagnosis and treatment of HCC can effectively reduce mortality.Carboxylesterase(CE)-specific detection and ...
关键词：chemiluminescent probes CARBOXYLESTERASE high-throughput inhibitor screening long-lived chemiluminescent image image-guided surgery 
Intestinal human carboxylesterase 2(CES2)expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice
《Acta Pharmacologica Sinica》2025年第3期777-793,共17页Yao-geng Wang Chang-pei Gan Joke Beukers-Korver Hilde Rosing Wen-long Li Els Wagenaar Maria CLebre Ji-ying Song Colin Pritchard Rahmen Bin Ali Ivo Huijbers Jos H.Beijnen Alfred H.Schinkel 
funded in part by the Chinese Scholarship Council(CSC Scholarships No.201506240107 to Yao-geng Wang,No.201506240145 to Chang-pei Gan and No.201606220081 to Wen-long Li);by the National Natural Science Foundation of China(82304647)of which Yao-geng Wang is a beneficiary.
Carboxylesterase 2(CES2)is expressed mainly in liver and intestine,but most abundantly in intestine.It hydrolyzes carboxylester,thioester,and amide bonds in many exogenous and endogenous compounds,including lipids.CES...
关键词：metabolic syndrome carboxylesterase 2 CAPECITABINE VINORELBINE lipid metabolism glucose homeostasis 
CES1 is associated with cisplatin resistance and poor prognosis of head and neck squamous cell carcinoma
《Oncology Research》2024年第12期1935-1948,共14页CHUAN JIANG CHUNLEI LIU XI YAO JINGYA SU WEI LU ZHENGBO WEI YING XIE 
supported by the National Natural Science Foundation of China(No.82160386);the Guangxi Natural Science Foundation of China(No.2024GXNSFDA010032,2023GXNSFAA026189).
Background:Head and neck squamous cell carcinoma(HNSCC)is a prevalent form of cancer globally,with chemoresistance posing a major challenge in treatment outcomes.The efficacy of the commonly used chemotherapeutic agent...
关键词：Carboxylesterase 1(CES1) Head and neck squamous cell carcinoma(HNSCC) CHEMORESISTANCE CISPLATIN SMOKING PROGNOSIS 
Cisplatin increases carboxylesterases through increasing PXR mediated by the decrease of DEC1
《The Journal of Biomedical Research》2023年第6期431-447,共17页Minqin Xu Lihua Zhang Lan Lin Zhiyi Qiang Wei Liu Jian Yang 
The work was supported by the National Natural Science Foundation of China(Grant Nos.82073934 and 81872937)to J.Y.
cis-Diamminedichloroplatinum(CDDP)is widely used for the treatment of various solid cancers.Here we reported that CDDP increased the expression and enzymatic activities of carboxylesterase 1(CES1)and carboxylesterase ...
关键词：cis-diamminedichloroplatinum pregnane X receptor differentiated embryonic chondrocyte-expressed gene 1 carboxylesterase 1 carboxylesterase 2 IRINOTECAN 
IL-33 Downregulates Hepatic Carboxylesterase 1 in Acute Liver Injury via Macrophage-derived Exosomal miR-27b-3p
《Journal of Clinical and Translational Hepatology》2023年第5期1130-1142,共13页Ping Gao Min Li Jingli Lu Daochun Xiang Ximin Wang Yanjiao Xu Yue Zu Xinlei Guan Guodong Li Chengliang Zhang 
supported by the National Natural Science Foundation of China(81670521 and 81803798).
Background and Aims:We previously reported that carboxylesterase 1(CES1)expression was suppressed following liver injury.The study aimed to explore the role of interleukin(IL)-33 in liver injury and examine the mechan...
关键词：IL-33 Carboxylesterase 1 miR-27b-3p Liver injury 
Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular mechanism of specnuezhenide in the treatment of colorectal cancer targeting carboxylesterase被引量：4
《Journal of Pharmaceutical Analysis》2023年第9期1024-1040,共17页Hang Yu Hui Xu Xinyu Yang Zhengwei Zhang Jiachun Hu Jinyue Lu Jie Fu Mengmeng Bu Haojian Zhang Zhao Zhai Jingyue Wang Jiandong Jiang Yan Wang 
supported by the National Key R&D Program of China(Grant No.:2022YFA0806400);the CAMS Innovation Fund for Medical Sciences(Grant Nos.:2022-I2M-1-028,2022-I2M-2-002,and 2021-I2M-1-007);the National Natural Science Foundation of China(Grant Nos.:81973290 and 82173888);Beijing Key Laboratory of Non-Clinical Drug Metabolism and PK/PD study,China(Grant No.:Z141102004414062)。
Specnuezhenide(SNZ)is among the main components of Fructus Ligustri Lucidi,which has antiinflammation,anti-oxidation,and anti-tumor effect.The low bioavailability makes it difficult to explain the mechanism of pharmac...
关键词：Specnuezhenide PHARMACOKINETICS Tumor Gut microbiota FUNGI Metabolism 
Genome-wide identification, classification, and expression profiling of serine esterases and other esterase-related proteins in the tobacco hornworm, Manduca sexta
《Insect Science》2023年第2期338-350,共13页Zelong Miao Chao Xiong Xiaolong Cao Tisheng Shan Qiao Jin Haobo Jiang 
supported by NIH grants GM58634 and AI139998.
Serine esterases(SEs)are hydrolases that catalyze the conversion of carboxylic esters into acids and alcohols.Lipases and carboxylesterases constitute two major groups of SEs.Although over a hundred of insect genomes ...
关键词：CARBOXYLESTERASE ESTERASE LIPASE PHOSPHOLIPASE phylogenetic analysis RNA-Seq THIOESTERASE 
Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism被引量：1
《Acta Pharmaceutica Sinica B》2023年第2期618-631,共14页Changpei Gan Jing Wang Alejandra Martínez-Chávez Michel Hillebrand Niels de Vries Joke Beukers Els Wagenaar Yaogeng Wang Maria C.Lebre Hilde Rosing Sjoerd Klarenbeek Rahmen Bin Ali Colin Pritchard Ivo Huijbers Jos H.Beijnen Alfred H.Schinkel 
funded in part by the China Scholarship Council(CSC Scholarship No.201506240145 to Changpei Gan)。
The mammalian carboxylesterase 1(Ces1/CES1)family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids.To investigate the pharmacological and physiological roles of Ces1/CES1,we gen...
关键词：Ces1/CES1 enzymes IRINOTECAN CAPECITABINE Adipose tissue Lipid homeostasis Inflammation Triglyceride mobilization Mouse models 
Accurate Assessment and Tracking the Process of Liver-Specific Injury by the Residual Tissue Activity of Carboxylesterase 1 and Dipeptidyl Peptidase 4被引量：1
《Engineering》2022年第12期153-165,共13页Qiusha Pan Peifang Song Zhenhua Ni Xingkai Qian Anqi Wang Liwei Zou Yong Liu Ping Wang Weidong Zhang Hong Ma Ling Yang 
This article is supported by the National Key Research and Development Program of China(2017YFC1702000,2020YFC0845400,and 2021YFE0200900);National Natural Science Foundation of China(81773810,81922070,and 81973393).The authors would like to thank Peter for his help in publishing the article,and the support provided by Zhaoyan(Suzhou)New Drug Research Center Co,.Ltd.
Accurately assessing and tracking the progression of liver-specific injury remains a major challenge in the field of biomarker research.Here,we took a retrospective validation approach built on the mutuality between s...
关键词：Carboxylesterase 1 Dipeptidyl peptidase 4 Liver injury Validation tracking 
Characterization of carboxylesterase PxαE8 and its role in multi-insecticide resistance in Plutella xylostella(L.)被引量：2
《Journal of Integrative Agriculture》2022年第6期1713-1721,共9页LI Ran SUN Xi LIANG Pei GAO Xi-wu 
supported by the National Natural Science Foundation of China (31371956, 31572023 and 31772186)
Carboxylesterase(CarE)was considered as important phase-I detoxifying enzymes which participated in detoxification of different types of insecticides.Up-regulation of CarE genes has been proved playing a major role in...
关键词：Plutella xylostella CARBOXYLESTERASE insecticide resistance BETA-CYPERMETHRIN PHOXIM 
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