云南高校图书馆联盟文献共享服务平台- PHARMACOKINETICS

PHARMACOKINETICS: 作品数：830被引量：2125H指数：16; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：郭瑞臣王本杰周田彦卢炜魏春敏更多>>; 相关机构：北京大学山东大学沈阳药科大学军事医学科学院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家高技术研究发展计划更多>>

Antibacterial,Antioxidant,Phytochemical Properties and GC-MS analyses of Mahareeb(Cymbopogon citratus): 《Food and Health》2025年第1期29-36,共8页Abdel Moniem Elhadi Sulieman Safa Mustafa Ibrahim Sohair A.Shommo Nosyba A.Ibrahim; Background: Medical plants are a diverse group of commercially important plants thatprovide raw materials for pharmaceuticals, perfumes, flavors, and cosmetics. They includenumerous secondary metabolites and may conta...; 关键词：PHOTOCHEMICAL PHARMACOKINETICS FLAVONOIDS GLYCOSIDES SAPONINS

Multi-target inhibition property of Persicaria hydropiper phytochemicals against gram-positive and gram-negative bacteria via molecular docking,dynamics simulation,and ADMET analysis: 《Digital Chinese Medicine》2025年第1期76-89,共14页Golak Majumdar Shyamapada Mandal; Research Grants of Senior Research Fellowship in favor of first author(Gloak Majumdar)from Council of Scientific and Industrial Research(CSIR,New Delhi,Government of India)(CSIR-SRF)with Award No.09/1151/(0008)2020-EMR-I.; Objective To evaluate the antibacterial potential of bioactive compounds from Persicaria hydropiper(L.)(P.hydropiper)against bacterial virulence proteins through molecular docking(MD)and experimental validation.Method...; 关键词：Persicaria hydropiper phytochemicals Molecular docking Molecular dynamics simulation Bacterial pathogenicity-related proteins PHARMACOKINETICS

Metabolic insights into gut microbiota in the pharmacology of natural medicines: 《Chinese Journal of Natural Medicines》2025年第2期158-168,共11页Zixin Chen Junchi Zhou Xiao Zheng Hao Xie Haiping Hao; supported by the National Key Research and Development Program of China (No.2021YFA1301300);the Na-tional Natural Science Foundation of China (Nos.82321005 and 82274009);the“Double-first”Discipline Funding of China Pharmaceutical University (No.CPUQNJC22_09);the Natural Science Foundation of Jiangsu Province of China (No.SKLNMZZ202202)。; Natural medicines(NMs)demonstrate distinct advantages in the clinical management of chronic diseases.Recent years have seen growing recognition of the gut microbiota's role in the efficacy and synergy of NMs,providing...; 关键词：Natural medicines Gut microbiota Metabolic signals PHARMACOKINETICS Drug discovery

^(19)F qNMR based pharmacokinetics,metabolism and mass balance studies of SARS-CoV-2-3CL protease inhibitor simnotrelvir(SIM0417)in humans: 《Acta Pharmacologica Sinica》2025年第2期489-499,共11页Ze-yu Wang Yong-mei Ren Shu-wei Hu Nai-xia Zhang Meng-xiao Dong Yun Li Yang Yang Zi-jia Guo Shan-sen Xu Jia Chen Aik Han Goh Xiao-yan Chen; supported by the National Natural Science Foundation of China(No.82073924)and grants from State Key Laboratory of Drug Research.; Simnotrelvir(SIM0417),an inhibitor of the 3CL protease of SARS-CoV-2,has been identified as a CYP3A sensitive substrate.This study investigated the pharmacokinetics,metabolism,and mass balance of simnotrelvir followin...; 关键词：COVID-19 simnotrelvir ^(19)F qNMR PHARMACOKINETICS METABOLISM mass balance.

Antiepileptic activity and potential mechanism of full-spectrum hemp extract: 《Fundamental Research》2025年第1期379-380,共2页Zengliang Jin Zhuo Huang; Epilepsy is the fourth most common neuropsychiatric disorder.Although the approval of Epidiolex has ignited hope for patients,there is still a large gap in the field of anti-seizure research.The effect and underlying ...; 关键词：HEMP CANNABINOIDS PHARMACOKINETICS Anti-seizure drugs GABA_(A)receptor

Safety,pharmacokinetics,and dosimetry of^(177)Lu-AB-3PRGD2 in patients with advanced integrinα_(v)β_(3)-positive tumors:A first-in-human study: 《Acta Pharmaceutica Sinica B》2025年第2期669-680,共12页Huimin Sui Feng Guo Hongfei Liu Rongxi Wang Linlin Li Jiarou Wang Chenhao Jia Jialin Xiang Yingkui Liang Xiaohong Chen Zhaohui Zhu Fan Wang; supported by Chinese Academy of Medical Science Innovation Fund for Medical Sciences(2022-I2M-2-002);the National High-Level Hospital Clinical Research Funding(2022-PUMCH-D-002,China);Clinical and translational medicine research project of the Chinese Academy of Medical Sciences(2022-I2M-C&T-A-008,China),the National Natural Science Foundation of China(82272046);the Fundamental Research Funds for the Central Universities(3332023124,China).; Integrinα_(v)β_(3)is overexpressed in various tumor cells and angiogenesis.To date,no drug has been proven to target it for therapy.A first-in-human study was designed to investigate the safety,pharmacokinetics,and ...; 关键词：^(177)Lu-AB-3PRGD2 Integrinα_(v)β_(3) Targeted radionuclide therapy First-in-human study PHARMACOKINETICS DOSIMETRY Safety Advanced tumors

Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer: 《Acta Pharmaceutica Sinica B》2025年第1期438-466,共29页Yang Li Yan Fang Xiaoyu Chen Linjiang Tong Fang Feng Qianqian Zhou Shulun Chen Jian Ding Hua Xie Ao Zhang; support from the China National Innovation of Science and Technology-2030(Program of Brain Science and Brain-Inspired Intelligence Technology,2021ZD0204004);the National Natural Science Foundation of China(Grants Nos.82273767,82073073,82122045,and 82273948);the Major Projects for Shanghai Zhang jiang National Independent Innovation of China(ZJ2021-ZD-007);Innovative research team of high-level local universities in Shanghai(SHSMU-ZDCX20210802,China);the Project of Shanghai Institute of Materia Medica,CAS(SIMM0120231001,China);the High-level Innovative Research Institute,Department of Science and Technology of Guangdong Province(2021B0909050003,China).; The p21-activated kinase 4(PAK4),a key regulator of malignancy,is negatively correlated with immune infiltration and has become an emergent drug target of cancer therapy.Given the lack of high efficacy PAK4 inhibitors...; 关键词：P21-activated kinase 4 Tetrahydrobenzofuro[2 3-clpyridine Structure-activity relationship Allosteric inhibitor Pharmacokinetics properties

Gut microbiota-mediated metabolism of Panax notoginseng saponins and its role in pharmacokinetics and pharmacodynamics: 《Traditional Medicine Research》2024年第12期41-50,共10页Yu-Ying Zheng Wei-Wei Su Yu-Ling Liu Wei-Jian Zhang Xuan Zeng; supported by Guangdong Basic and Applied Basic Research Foundation(No.2022A1515012039);Guangzhou Science and Technology Plan Project(No.2024A03J0360).; Panax notoginseng saponins(PNS)are a class of effective ingredients in Notoginseng Radix et Rhizoma,a well-known herbal medicine called San-Qi in Chinese.After oral administration,PNS inevitably interacts with gut mic...; 关键词：Panax notoginseng saponins gut microbiota METABOLISM PHARMACOKINETICS PHARMACODYNAMICS

Biopharmaceutical and pharmacokinetic attributes to drive nanoformulations of small molecule tyrosine kinase inhibitors: 《Asian Journal of Pharmaceutical Sciences》2024年第6期48-83,共36页Soumyadip Mukherjee Vedant Joshi Kolimi Prashanth Reddy Nidhi Singh Priyanka Das Pallab Datta; Buoyed by the discovery of small-molecule tyrosine kinase inhibitors(smTKIs),significant impact has been made in cancer chemotherapeutics.However,some of these agents still encounter off-target toxicities and suboptim...; 关键词：PHARMACOKINETICS Tyrosine kinase inhibitors NANOPARTICLES Liposomes Peak plasma concentration

Non-small-molecule therapeutics for drug addiction:From pharmacokinetics modulating to synthetic biology被引量：1: 《Fundamental Research》2024年第6期1398-1400,共3页Yuanpeng Li Yibo Wang Lin Lu Jie Shi Xiaohui Wang; supported by the Brain Science and Brain-Like Intelligence Technology Program(2021ZD0203003);Beijing National Laboratory for Molecular Sciences(BNLMS202108);the Chinese Academy of Sciences Pioneer Hundred Talents Program.; Drug addiction is a pervasive problem worldwide.It not only affects the abuser’s life,but also poses a serious threat to public health.Accordingly,there is a strong demand for the development of novel and effective t...; 关键词：Drug abuse Enzymatic degradation Gene therapy Synthetic biology PHARMACOKINETICS

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