Gut microbiota-mediated metabolism of Panax notoginseng saponins and its role in pharmacokinetics and pharmacodynamics  

作　　者：Yu-Ying Zheng Wei-Wei Su Yu-Ling Liu Wei-Jian Zhang Xuan Zeng 

机构地区：[1]Experimental Center,the First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China [2]Guangdong Engineering&Technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine,Guangdong Provincial Key Laboratory of Plant Resources,School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China [3]Department of Neurosurgery,First People’s Hospital of Foshan,Foshan 528010,China [4]Guangdong Hybribio Biotech Co.,Ltd.,Chaozhou 521011,China

出　　处：《Traditional Medicine Research》2024年第12期41-50,共10页TMR传统医学研究

基　　金：supported by Guangdong Basic and Applied Basic Research Foundation(No.2022A1515012039);Guangzhou Science and Technology Plan Project(No.2024A03J0360).

摘　　要：Panax notoginseng saponins(PNS)are a class of effective ingredients in Notoginseng Radix et Rhizoma,a well-known herbal medicine called San-Qi in Chinese.After oral administration,PNS inevitably interacts with gut microbiota,and thus affect the pharmacokinetic profiles and pharmacological effects.To date,studies concering gut microbiota-mediated metabolism of PNS have not been reviewed systematically.Herein,we outline the metabolic profiles of Panax notoginseng saponins mediated by gut microbiota,as well as its role in the pharmacokinetics and pharmacodynamics on the basis of reported data.The metabolic pathways of primary saponins are proposed,and step-by-step deglycosylation is found to be the primary degradation pathways of PNS mediated by gut microbiota.Specific microorganisms and enzymes involved in the metabolic processes were summarized.Gut microbiota is deeply involved in the metabolism of PNS,affects the pharmacokinetic profiles,and produces a series of active metabolites.These metabolites were documented to play an essential role in the efficacy of the parent compounds.Future studies should focus on strengthening the real-world evidence,defining the interaction between gut microbiota and PNS,and developing the strategy for modulating gut microbiota to enhance the bioavailability and efficacy of PNS.These information would be useful for further research and clinical application of PNS.

关 键 词：Panax notoginseng saponins gut microbiota METABOLISM PHARMACOKINETICS PHARMACODYNAMICS 

分 类 号：R285.5[医药卫生—中药学]