THIOESTERASE

作品数：11被引量：14H指数：2
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相关领域：生物学更多>>
相关作者：卢孟柱张德强周洲更多>>
相关机构：中国林业科学研究院北京大学更多>>
相关期刊：《Journal of Chinese Pharmaceutical Sciences》《Chinese Journal of Chemical Engineering》《Acta Pharmacologica Sinica》《生物物理学报》更多>>
相关基金：国家自然科学基金山西省自然科学基金国家重点基础研究发展计划更多>>
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Activation of D2-like dopamine receptors improves the neuronal network and cognitive function of PPT1KI mice
《Acta Pharmacologica Sinica》2025年第2期338-352,共15页Jun-qiang Zhao Bing-yan Feng Zhen-li Ye Xiao-yin Ma Jing-zhi Du Jun-mei Li Wan-liu Wu Jing-jing Gao Song-ji Li Shi-yong Peng Ji-sen Huai Li-hao Ge Cheng-biao Lu 
supported by the National Natural Science Foundation of China(NSFC:81771517,81271422);the Key Project of the 14th Five-Year Plan of Educational Science in Henan Province(2021JKZD09);the Key Scientific and Technological Project in Henan Province(212102310654);the Henan Province Medical Science and Technology Key Project Jointly Constructed by Province and Ministry(SBGJ202102189);the Key R&D and Promotion Projects in Henan Province(222102310615);Natural Science Foundation of Henan Province(242300421307);the Tai-hang Scholar Research Fund from Xinxiang Medical University;and the Henan Collaborative Innovation Center of Prevention and Treatment of Mental Disorders,the Second Affiliated Hospital of Xinxiang Medical University(XTkf11).
Palmitoyl-protein thioesterase 1(PPT1)is a lysosomal depalmitoylation enzyme that mediates protein posttranslational modifications.Loss-of-function mutation of PPT1 causes a failure of the lysosomal degradation of pal...
关键词：infantile neuronal ceroid lipofuscinosis palmitoyl-protein thioesterase 1 cognitive functions γoscillations DOPAMINE dopamine D4 receptor 
Editing function of type Ⅱ thioesterases in the biosynthesis of fungal polyketides
《Chinese Chemical Letters》2024年第10期325-328,共4页Fenglin Jiang Anan Liu Qian Wei Youcai Hu 
supported financially by the National Natural Science Foundation of China(Nos.82225042,T2192973);the CAMS Innovation Fund for Medical Sciences(No.CIFMS 2021-I2M1-029)。
Polyketide synthases(PKSs)are megasynthases with multiple autonomously folding domains,which operate cooperatively in the PKS assemblies to synthesize specific polyketide scaffolds.Any nonreactive intermediates tether...
关键词：Editing enzyme Type II thioesterase BIOSYNTHESIS Polyketide synthase Metabolic engineering 
Roles of THEM4 in the Akt pathway:a double-edged sword
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第7期541-556,共16页Wen XIE Weidong LIU Lei WANG Bin ZHU Cong ZHAO Ziling LIAO Yihan LI Xingjun JIANG Jie LIU Caiping REN 
supported by the National Natural Science Foundation of China(Nos.82071399 and 81773179);the Key Research and Development Program of Hunan Province(No.2022SK2055);the Natural Science Foundation of Hunan Province(No.2023JJ30733),China.
The protein kinase B(Akt)pathway can regulate the growth,proliferation,and metabolism of tumor cells and stem cells through the activation of multiple downstream target genes,thus affecting the development and treatme...
关键词：Protein kinase B(Akt) Thioesterase superfamily member 4(THEM4) Tumor proliferation Tumor metastasis 
Investigation of GhFAT Genes Related to Seed Oil Content and Fatty Acid Composition in Gossypium hirsutum L.
《Phyton-International Journal of Experimental Botany》2023年第5期1633-1647,共15页Ziyang Feng Xinqi Cheng Tianwen Wang Yongchao Han Haihong Chen Xinyu Zhang Jie Sun Wei Zhang Feng Liu 
This work was financially supported by the National Natural Science Foundation of China[31960369];the Project for Crops Breeding of Shihezi University[YZZX201803]。
Fatty Acyl-ACP thioesterase(FAT)is a key enzyme controlling oil biosynthesis in plant seeds.FATs can be divided into two subfamilies,FATA and FATB according to their amino acid sequences and substrate specificity.The ...
关键词：Gossypium hirsutum fatty Acyl-ACP thioesterase biological information expression profile seed vigor 
Genome-wide identification, classification, and expression profiling of serine esterases and other esterase-related proteins in the tobacco hornworm, Manduca sexta
《Insect Science》2023年第2期338-350,共13页Zelong Miao Chao Xiong Xiaolong Cao Tisheng Shan Qiao Jin Haobo Jiang 
supported by NIH grants GM58634 and AI139998.
Serine esterases(SEs)are hydrolases that catalyze the conversion of carboxylic esters into acids and alcohols.Lipases and carboxylesterases constitute two major groups of SEs.Although over a hundred of insect genomes ...
关键词：CARBOXYLESTERASE ESTERASE LIPASE PHOSPHOLIPASE phylogenetic analysis RNA-Seq THIOESTERASE 
Cyclic peptide molecular biosynthesis-the group of Professor Ming Ma discovered the first catalytic isomerization/cyclic bifunctional thioesterase and analyzed its crystal structure
《Journal of Chinese Pharmaceutical Sciences》2021年第9期778-779,共2页无 
2021年9月7日,北京大学药学院天然药物及仿生药物国家重点实验室马明研究团队在美国化学会《ACS Catalysis》上发表了题为"Functional characterization and crystal structure of the bifunctional thioesterase catalyzing epimerizat...
关键词：美国化学会 晶体结构 分子生物 环肽 硫酯酶 结构单元 
Characterization of the Formation of Branched Short-Chain Fatty Acid：CoAs for Bitter Acid Biosynthesis in Hop Glandular Trichomes被引量：9
《Molecular Plant》2013年第4期1301-1317,共17页Haiyang Xu Fengxia Zhang Baoxiu Liu David V. Huhman Lloyd W. Sumner Richard A. Dixon Guodong Wang 
the National Program on Key Basic Research Projects，the 'One hundred talents' project of the Chinese Academy of Sciences，the National Natural Sciences Foundation of China，the National Science Foundation，the State Key Laboratory of Plant Genomics of China
Bitter acids, known for their use as beer flavoring and for their diverse biological activities, are predominantly formed in hop （Humulus lupulus） glandular trichomes. Branched short-chain acyI-CoAs （e.g. isobutyry...
关键词：CoA ligase glandular trichomes bitter acid THIOESTERASE evolution Humulus lupulus 
Direct Observation of Arthrobacter 4-Hydroxybenzoyl-Coenzyme A Thioesterase Catalysis complexes using Electrospray Ionization Mass Spectrometry
《生物物理学报》2009年第S1期163-164,共2页Debra Dunaway-Mariano Karen S.Anderson 
Investigating enzymatic reaction in multimeric enzymes is utmost interest to improve our understanding of the mechanism of enzymatic reaction and regulation. In this study,
关键词：ARTHROBACTER THIOESTERASE multinary enzyme-ligand complex mass SPECTROMETRY 
Cloning and Expression Analysis of PtFATB Gene Encoding the Acyl-acyl Carrier Protein Thioesterase in Populus tomentosa Carr被引量：1
《Journal of Genetics and Genomics》2007年第3期267-274,共8页周洲 张德强 卢孟柱 
This work was supported by project "Regulation of Composition and Saturation of Fatty Acid in Trees by Genetic Engineering", Introduction of Foreign Advanced Agricultural Science and Technology into China (No. 2005-4-52).
Acyl-ACP thioesterases （FATs） terminates the fatty acid synthesis and allow the transport of fatty acids out of the plastids, which are the important determinants of cellular metabolism. FATB is a member of FAT enzy...
关键词：Populus tomentosa Carr. Acyl-acyl carrier protein thioesterase （PtFATB） in silico and molecular cloning RT-PCR expression analysis 
A Novel Method for Production of 3-Hydroxydecanoic Acid by Recombinant Escherichia coli and Pseudomonas putida被引量：3
《Chinese Journal of Chemical Engineering》2004年第4期550-555,共6页郑重 宫强 陈国强 
Supported by the State Outstanding Young Scientist Award from National Natural Sciences Foundation of China (No. 20334020).
3-hydroxydecanoic acid (3HD) is an interesting intermediate for chemical synthesis of many valuable compounds. A novel method to produce 3HD by recombinant bacteria was constructed in Escherichia coli HB101 and Pseudo...
关键词：3-Hydroxydecanoic acid POLYHYDROXYALKANOATES Escherichia coli Pseudomonas puticfa (R)-3-hydroxydecanoyl-ACP:CoA transacylase thioesterase Ⅱ PHB 
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