Roles of THEM4 in the Akt pathway:a double-edged sword  

作　　者：Wen XIE Weidong LIU Lei WANG Bin ZHU Cong ZHAO Ziling LIAO Yihan LI Xingjun JIANG Jie LIU Caiping REN 

机构地区：[1]NHC Key Laboratory of Carcinogenesis,Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha 410008,China [2]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Central South University,Changsha 410008,China [3]The Key Laboratory of Carcinogenesis and Cancer Invasion of the Ministry of Education,Cancer Research Institute,School of Basic Medical Science,Central South University,Changsha 410078,China [4]Department of Critical Care Medicine,Hainan Hospital of Chinese PLA General Hospital,Hainan Province Clinical Medical Center,Sanya 572013,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第7期541-556,共16页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Natural Science Foundation of China(Nos.82071399 and 81773179);the Key Research and Development Program of Hunan Province(No.2022SK2055);the Natural Science Foundation of Hunan Province(No.2023JJ30733),China.

摘　　要：The protein kinase B(Akt)pathway can regulate the growth,proliferation,and metabolism of tumor cells and stem cells through the activation of multiple downstream target genes,thus affecting the development and treatment of a range of diseases.thioesterase superfamily member 4(THEM4),a member of the thioesterase superfamily,is one of the Akt kinase-binding proteins.Some studies on the mechanism of cancers and other diseases have shown that THEM4 binds to Akt to regulate its phosphorylation.Initially,THEM4 was considered an endogenous inhibitor of Akt,which can inhibit the phosphorylation of Akt in diseases such as lung cancer,pancreatic cancer,and liver cancer,but subsequently,THEM4 was shown to promote the proliferation of tumor cells by positively regulating Akt activity in breast cancer and nasopharyngeal carcinoma,which contradicts previous findings.Considering these two distinct views,this review summarizes the important roles of THEM4 in the Akt pathway,focusing on THEM4 as an Akt-binding protein and its regulatory relationship with Akt phosphorylation in various diseases,especially cancer.This work provides a better understanding of the roles of THEM4 combined with Akt in the treatment of diseases.

关 键 词：Protein kinase B(Akt) Thioesterase superfamily member 4(THEM4) Tumor proliferation Tumor metastasis 

分 类 号：R730[医药卫生—肿瘤]