VINORELBINE

作品数：32被引量：51H指数：5
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相关领域：医药卫生更多>>
相关作者：熊茵李江张杰杨新科于欣欣更多>>
相关机构：华中科技大学第四军医大学中国预防医学科学院北京大学更多>>
相关期刊：《外文科技期刊数据库（文摘版）医药卫生》《Digital Chinese Medicine》《Cancer Pathogenesis and Therapy》《Journal of Cancer Therapy》更多>>
相关基金：国家自然科学基金中国博士后科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Intestinal human carboxylesterase 2(CES2)expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice
《Acta Pharmacologica Sinica》2025年第3期777-793,共17页Yao-geng Wang Chang-pei Gan Joke Beukers-Korver Hilde Rosing Wen-long Li Els Wagenaar Maria CLebre Ji-ying Song Colin Pritchard Rahmen Bin Ali Ivo Huijbers Jos H.Beijnen Alfred H.Schinkel 
funded in part by the Chinese Scholarship Council(CSC Scholarships No.201506240107 to Yao-geng Wang,No.201506240145 to Chang-pei Gan and No.201606220081 to Wen-long Li);by the National Natural Science Foundation of China(82304647)of which Yao-geng Wang is a beneficiary.
Carboxylesterase 2(CES2)is expressed mainly in liver and intestine,but most abundantly in intestine.It hydrolyzes carboxylester,thioester,and amide bonds in many exogenous and endogenous compounds,including lipids.CES...
关键词：metabolic syndrome carboxylesterase 2 CAPECITABINE VINORELBINE lipid metabolism glucose homeostasis 
Reductive lipid nanoparticles loaded with vinorelbine inhibit chemotherapy-induced invasion of cancer cells by modulating ENPP2
《Nano Research》2024年第4期2886-2898,共13页Xiaoqi Zhao Xuemeng Guo Mei Pang Weigen Qiu Zhenyu Luo Qing Lin Yichao Lu Hang Yin Sijie Wang Huihui Liu Junlei Zhang Lihua Luo Jian You 
supported by the National Natural Science Foundation of China(No.81973246);Public Welfare Project of Zhejiang Natural Science Foundation(No.GF22H308848).
Cancer is a predominant culprit behind worldwide death and accounts for up to 10 million deaths every year.Chemotherapy is the primary therapeutic method employed for cancer in clinical settings and is essential in co...
关键词：chemotherapy VINORELBINE tumor Invasion lysophosphatidic acid ectonucleotide pyrophosphatase/phosphodiesterase 2(ENPP2) 
Inetetamab combined with pyrotinib and oral vinorelbine for patients with human epidermal growth factor receptor 2 positive advanced breast cancer:A single-arm phase 2 clinical trial被引量：1
《Cancer Pathogenesis and Therapy》2024年第1期31-37,共7页Nan Jin Yi Xu Siqi Wang Chunxiao Sun Xueqi Yan Fan Yang Yan Liang Weiwei Chen Xiang Huang 
This study was supported by the Chinese Society of Clinical Oncology(CSCO)Research Foundation of Beijing(No.Y-pierrefabre202101-0109).
Background Human epidermal growth factor receptor 2(HER2)-targeted agents have significantly improved the outcomes of patients with HER2-positive breast cancer;however,a large proportion of patients still develop resi...
关键词：Human epidermal growth factor receptor 2 Breast cancer Inetetamab Pyrotinib VINORELBINE 
Combined chemo-endocrine therapy as a potential new option for HR+/HER2−advanced breast cancer:a prospective study of fulvestrant plus oral vinorelbine
《Cancer Biology & Medicine》2023年第4期287-296,共10页Xue Wang Jian Yue Yikun Kang Zhong Dai Jie Ju Jiayu Wang Pin Zhang Fei Ma Binghe Xu Peng Yuan 
supported by grants from the National Key R&D Program of China(Grant No.2018YFC0115204);the National Natural Science Foundation of China(Grant No.81672634);the Chinese Society of Clinical Oncology Foundation(Grant No.Y-2019AZMS-0377);the Beijing Medical Award Foundation(Grant No.YXJL-2020-0941-0763);Beijing Hope Run Special Fund of Cancer Foundation of China(Grant No.LC2019B16);Beijing Xisike Clinical Oncology Research Foundation(Grant No.Y-pirrefabre202101-0008).
Objective:Endocrine therapy with fulvestrant has shown synergistic antitumor effects with some chemotherapy drugs in vitro.This study evaluated the efficacy and safety of fulvestrant with vinorelbine in patients with ...
关键词：HR+/HER2−breast cancer RECURRENCE metastasis FULVESTRANT oral vinorelbine 
Clinical Analysis of Trastuzumab Combined with Different Chemotherapy Drugs in the Treatment of Breast Cancer
《外文科技期刊数据库(文摘版)医药卫生》2022年第9期063-066,共4页JIANGXiaojing 
Objective: to investigate the clinical efficacy of trastuzumab combined with different chemotherapy drugs in the treatment of breast cancer. Methods: the clinical data of 90 patients with breast cancer treated with tr...
关键词：TRASTUZUMAB ANTIBODY chemotherapy drugs breast cancer VINORELBINE DOCETAXEL 
Meta-analysis of efficacy and safety of Endostar combined with vinorelbine and cisplatin in the treatment of non-small cell lung cancer
《Journal of Hainan Medical University》2022年第8期29-35,共7页Ze-Yun Li Qing-Xia Lan Cheng-Xin Liu Zhe Sun Yang Cao 
General Program of the National Natural Science Foundation of China(No.81973815);General Program of Fund of the Traditional Chinese Medicine Bureau of Guangdong Province(No.20201107)。
Objective:To systematically evaluate the efficacy and safety of rh-endostain(YH-16,Endostar)combined with vinorelbine and cisplatin(NP regimen)in the treatment of non-small cell lung cancer(NSCLC),and to provide evide...
关键词：Rh-endostain VINORELBINE CISPLATIN Non-small cell lung cancer Therapeutic efficacy Safety META-ANALYSIS 
Phase Ⅱ study of apatinib in combination with oral vinorelbine in heavily pretreated HER2-negative metastatic breast cancer and clinical implications of monitoring ctDNA被引量：4
《Cancer Biology & Medicine》2021年第3期875-887,共13页Anjie Zhu Peng Yuan Nanlin Hu Mingzhou Li Wenmiao Wang Xue Wang Jian Yue Jiayu Wang Yang Luo Fei Ma Pin Zhang Qing Li Binghe Xu Shanbo Cao Giuseppe Lippi Yoichi Naito Mohammed A.Osman Gustavo N.Marta Gianluca Franceschini Armando Orlandi 
funded by the National Natural Science Foundation of China(Grant No.81472753 and 81672634)。
Objective:Apatinib is an oral TKI targeting VEGFR-2.Single-agent apatinib treatment has been shown to produce an objective response in patients with pretreated m BC.Oral vinorelbine also holds promise as a treatment o...
关键词：Metastatic breast cancer apatinib oral vinorelbine ct DNA 
Oral Vinorelbine as Switch Maintenance Therapy versus Best Supportive Care in Patients with Advanced Adenocarcinoma Non-Small Cell Lung Cancer EGFR Wild Type
《Journal of Cancer Therapy》2019年第12期908-914,共7页Amen Hamdy Zaky Ahmed Refaat Abd Elzaher Ola Nabih 
Background: This study was performed to evaluate the efficacy and safety of switch maintenance therapy with oral vinorelbine in advanced non-small cell lung cancer (NSCLC) with adenocarcinoma limited to epidermal grow...
关键词：Lung Cancer Maintenance CHEMOTHERAPY VINORELBINE EGFR-Wild Type 
Clinical Efficacy and Safety of Oxaliplatin-tegafur,Gimeracil and Oteracil Potassium and Vinorelbine-Pt in the Treatment of Advanced Triple Negative Breast Cancer
《Advances in Modern Oncology Research》2019年第5期21-24,共4页Miroslav Samaržija Lela Bitar 
The purpose of this study was to investigate the efficacy and safety of oxaliplatin combined with tegafur,gimeracil and oteracil potassium(SOX regimen)and vinorelbine combined with Pt(NP regimen)in the treatment of ad...
关键词：OXALIPLATIN Tegafur gimeracil and oteracil potassium VINORELBINE PT 
Effects of Pachyman in Combination with Vinorelbine and Cisplatin on Tumor Growth and the Expression of EGFR and K-ras in Mice with Lung Cancer被引量：9
《Digital Chinese Medicine》2018年第4期310-315,共6页Ke WEI Jia-Hao ZHOU Yong-Chao CHEN Jia-Ming TIAN Meng-Jin SUN Xin-Wen DAI Bai-Hui LI Ling LI Fang-Liang ZHOU Yi NING Jue HU Qin XIANG Bo ZHANG Fang-Guo LU 
support from the National Natural Science Foundation of China(No.81774126,No.81503445 and No.81703919);China Postdoctoral Science Foundation(No.2017M622587);Hunan Provincial Natural Science Foundation(No.2016JJ2095 and No.2017JJ3232);Hunan Provincial Traditional Chinese Medicine Key Research Project(No.201701);Hunan Education Department Scientific Research Project(16C1203 and 16C1216);Hunan Health Department Scientific Research Project(C2015-16,C2016049 and B2016093);Busky Pharmaceutical Collaborative Research Fund,Hunan Provincial Higher Educational Institutions Research Team "Traditional Chinese Medicine prevention and treatment research on infectious diseases" Funding program(No.15);Hunan Province Teaching and Science "Thirteenth Five-Year Plan" Project(No.XJK17BGD057)
Objective To examine the effects of pachyman in combination with vinorelbine and cisplatin on tumor growth and the expression of epidermal growth factor receptor(EGFR)and K-ras in a mouse model of lung cancer induced ...
关键词：Pachyman VINORELBINE CISPLATIN Lung cancer EGFR K-RAS 
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