funded in part by grants from the Danish Cancer Society(to Henrik J.Ditzel);Health Insurance“Denmark”(to Henrik J.Ditzel);Academy of Geriatric Cancer Research(AgeCare)(to Henrik J.Ditzel);Pink Tribute(to Henrik J.Ditzel).
Dear Editor,Despite the improved outcome of advanced estrogen receptor-positive(ER+)breast cancer patients treated with endocrine therapy in combination with either a cyclindependent kinase 4/6 inhibitor(CDK4/6i)or a ...
supported by grants from the National Key R&D Program of China(Grant No.2018YFC0115204);the National Natural Science Foundation of China(Grant No.81672634);the Chinese Society of Clinical Oncology Foundation(Grant No.Y-2019AZMS-0377);the Beijing Medical Award Foundation(Grant No.YXJL-2020-0941-0763);Beijing Hope Run Special Fund of Cancer Foundation of China(Grant No.LC2019B16);Beijing Xisike Clinical Oncology Research Foundation(Grant No.Y-pirrefabre202101-0008).
Objective:Endocrine therapy with fulvestrant has shown synergistic antitumor effects with some chemotherapy drugs in vitro.This study evaluated the efficacy and safety of fulvestrant with vinorelbine in patients with ...
For the quantitative determination of Fulvestrant, Benzyl alcohol, and Benzyl benzoate in Fulvestrant injection, an original RP-HPLC approach was developed. The gradient method was developed using HPLC and a Phenomene...
supported by grants from the Cancer Prevention Research Institute of Texas(RP130266);the Carson-Leslie Foundation and the Association for Research of Childhood Cancer
Endocrine therapy using estrogen receptor-u (ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers. To exploit any DNA repair deficiencies associated ...
Aim Breast cancer is one of the lethal gynecological malignancy in the world. Tamoxifen (TAM) and fulvestrant (FUL) are the major drugs for patients with estrogen receptor-positive (ER + ) breast cancers. Howev...
The 88 kDa glycoprotein known as GP88, Progranulin or PC cell derived growth factor is an autocrine growth factor with a unique cysteine rich motif that is over expressed in breast cancer whereas it is negative in nor...
Although a wide range of studies have addressed the relationship between estrogen receptor(ER) expression and prognosis in non-small cell lung cancer(NSCLC), that relationship remains controversial. This is in large p...
Supported by The Karoji Memorial Fund of the Hirosaki University Graduate School of Medicine
The role of hormone therapy in the treatment of ovarian cancer is not clear. Data on the efficacy and safety of antiestrogens and aromatase inhibitors in recurrent ovarian cancer have been accumulated through phase Ⅱ...