FULVESTRANT

作品数:17被引量:43H指数:4
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相关领域:医药卫生更多>>
相关作者:王佳玉徐兵河祝德秋崔岚安富荣更多>>
相关机构:重庆医科大学中国医学科学院肿瘤医院上海第二医科大学附属仁济医院山东大学第二医院更多>>
相关期刊:《World Journal of Clinical Cases》《癌症进展》《World Journal of Clinical Oncology》《Cancer Communications》更多>>
相关基金:国家自然科学基金重庆市自然科学基金重庆市卫生局科研项目更多>>
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Triple combination targeting PI3K,ER,and CDK4/6 inhibits growth of ER-positive breast cancer resistant to fulvestrant and CDK4/6 or PI3K inhibitor
《Cancer Communications》2023年第6期720-725,共6页Mikkel G.Terp Martina Tuttolomondo Neil Portman Sidse Ehmsen Lene E.Johansen Martin Bak Elgene Lim Henrik J.Ditzel 
funded in part by grants from the Danish Cancer Society(to Henrik J.Ditzel);Health Insurance“Denmark”(to Henrik J.Ditzel);Academy of Geriatric Cancer Research(AgeCare)(to Henrik J.Ditzel);Pink Tribute(to Henrik J.Ditzel).
Dear Editor,Despite the improved outcome of advanced estrogen receptor-positive(ER+)breast cancer patients treated with endocrine therapy in combination with either a cyclindependent kinase 4/6 inhibitor(CDK4/6i)or a ...
关键词:PIK3CA BREAST cancer 
Combined chemo-endocrine therapy as a potential new option for HR+/HER2−advanced breast cancer:a prospective study of fulvestrant plus oral vinorelbine
《Cancer Biology & Medicine》2023年第4期287-296,共10页Xue Wang Jian Yue Yikun Kang Zhong Dai Jie Ju Jiayu Wang Pin Zhang Fei Ma Binghe Xu Peng Yuan 
supported by grants from the National Key R&D Program of China(Grant No.2018YFC0115204);the National Natural Science Foundation of China(Grant No.81672634);the Chinese Society of Clinical Oncology Foundation(Grant No.Y-2019AZMS-0377);the Beijing Medical Award Foundation(Grant No.YXJL-2020-0941-0763);Beijing Hope Run Special Fund of Cancer Foundation of China(Grant No.LC2019B16);Beijing Xisike Clinical Oncology Research Foundation(Grant No.Y-pirrefabre202101-0008).
Objective:Endocrine therapy with fulvestrant has shown synergistic antitumor effects with some chemotherapy drugs in vitro.This study evaluated the efficacy and safety of fulvestrant with vinorelbine in patients with ...
关键词:HR+/HER2−breast cancer RECURRENCE metastasis FULVESTRANT oral vinorelbine 
A Novel RP-HPLC Method for Estimating Fulvestrant, Benzoyl Alcohol, and Benzyl Benzoate in Injection Formulation被引量:1
《American Journal of Analytical Chemistry》2022年第7期229-240,共12页Arjuna Rao Nekkalapudi Venu Gopal Veldi Sreenivas Pippalla 
For the quantitative determination of Fulvestrant, Benzyl alcohol, and Benzyl benzoate in Fulvestrant injection, an original RP-HPLC approach was developed. The gradient method was developed using HPLC and a Phenomene...
关键词:FULVESTRANT Injection Formulation HPLC ASSAY Benzyl Alcohol and Benzyl Benzoate 
国外新批准上市的药物新制剂新剂型(259)
《中国制药信息》2019年第10期15-16,25,共3页黄胜炎(摘译) 
1.美国FDA批准阿配利西(Alpelisib)薄膜包衣片上市美国FDA批准诺华公司产品(商品名:Piqray)上市,与美国FDA已批准上市的内分泌治疗药氟维司群(Fulvestrant)联合用药,在疾病发展或内分泌基础给药方案后治疗激素受体阳性、人表皮生长因子...
关键词:批准上市 药物新制剂 FULVESTRANT 人表皮生长因子受体2 新剂型 美国FDA FDA批准 国外 
^(131)I-fulvestrant的合成与鉴定
《重庆医科大学学报》2018年第1期112-116,共5页印国兵 曾斌 刘瑛 孙璐 廖艳玲 
重庆市科委自然科学基金计划资助项目(编号:cstc2012jjA10042);重庆市卫生局科研基金资助项目(编号:2011-2-175)
目的:建立氟维司群(fulvestrant)放射性碘(^(131)I)标记技术。方法:采用改良氯胺-T法对氟维司群进行放射性碘标记,纸层析法测定标记率及标记物稳定性,柱层析法分离及纯化,质谱法鉴定标记化合物,细胞结合实验及MTT实验检测标记化合物对MC...
关键词:放射性碘(131I) 氟维司群 改良氯胺T法 
New insights into estrogenic regulation of O^6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O^6-benzylguanine indicates fresh avenues for therapy被引量:5
《The Journal of Biomedical Research》2016年第5期393-410,共18页Ameya Paranjpe Nathan I. Bailes Santhi Konduri George C. Bobustuc Francis Ali-Osman Mohd. A. Yusuf Surendra R. Punganuru Hanumantha Rao Madal Debasish Basak AGM Mostofa Kalkunte S. Srivenugopa 
supported by grants from the Cancer Prevention Research Institute of Texas(RP130266);the Carson-Leslie Foundation and the Association for Research of Childhood Cancer
Endocrine therapy using estrogen receptor-u (ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers. To exploit any DNA repair deficiencies associated ...
关键词:estrogen signaling MGMT DNA repair ubiquitin-proteasome pathway breast cancer anti-estrogens 
MiR-214 increases the sensitivity of breast cancer cells to tamoxifen and fulvestrant through inhibition of autophagy被引量:14
《中国药理学通报》2015年第B11期243-243,共1页
Aim Breast cancer is one of the lethal gynecological malignancy in the world. Tamoxifen (TAM) and fulvestrant (FUL) are the major drugs for patients with estrogen receptor-positive (ER + ) breast cancers. Howev...
关键词:ER + breast cancer ENDOCRINE resistance apoptosis AUTOPHAGY miR-214 UCP2 
GP88 (Progranulin) Confers Fulvestrant (Faslodex, ICI 182,780) Resistance to Human Breast Cancer Cells
《Advances in Breast Cancer Research》2014年第3期68-78,共11页Wisit Tangkeangsirisin Ginette Serrero 
The 88 kDa glycoprotein known as GP88, Progranulin or PC cell derived growth factor is an autocrine growth factor with a unique cysteine rich motif that is over expressed in breast cancer whereas it is negative in nor...
关键词:Progranulin (GP88) FULVESTRANT FASLODEX BREAST Cancer Anti-Estrogen RESISTANCE 
Estrogen receptors as the novel therapeutic biomarker in non-small cell lung cancer被引量:4
《World Journal of Clinical Oncology》2014年第5期1020-1027,共8页Hideki Kawai 
Although a wide range of studies have addressed the relationship between estrogen receptor(ER) expression and prognosis in non-small cell lung cancer(NSCLC), that relationship remains controversial. This is in large p...
关键词:ESTROGEN RECEPTOR NON-SMALL cell lung cancer EPIDERMAL growth factor RECEPTOR FULVESTRANT Combined therapy 
Recurrent epithelial ovarian cancer and hormone therapy
《World Journal of Clinical Cases》2013年第6期187-190,共4页Yoshihito Yokoyama Hideki Mizunuma 
Supported by The Karoji Memorial Fund of the Hirosaki University Graduate School of Medicine
The role of hormone therapy in the treatment of ovarian cancer is not clear. Data on the efficacy and safety of antiestrogens and aromatase inhibitors in recurrent ovarian cancer have been accumulated through phase Ⅱ...
关键词:Recurrent OVARIAN cancer HORMONE therapy LETROZOLE ANASTROZOLE TAMOXIFEN FULVESTRANT 
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