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Global stability of the plane wave solutions to the relativistic string equation with non-small perturbations
《Science China Mathematics》2025年第2期339-378,共40页Jinhua Wang Changhua Wei 
supported by National Natural Science Foundation of China(Grant Nos.12271450 and 11871408);supported by National Natural Science Foundation of China(Grant Nos.12071435 and 11871212);Zhejiang Provincial Outstanding Youth Science Foundation(Grant No.LR22A010004);the Fundamental Research Fund of Zhejiang Sci-Tech University。
This paper is concerned with the global stability of the plane wave solutions to the relativistic string equation with non-small perturbations.Under certain decay assumptions on the plane wave,we conclude that the per...
关键词：relativistic string plane wave null condition large energy global existence 
Non-small-molecule therapeutics for drug addiction:From pharmacokinetics modulating to synthetic biology被引量：1
《Fundamental Research》2024年第6期1398-1400,共3页Yuanpeng Li Yibo Wang Lin Lu Jie Shi Xiaohui Wang 
supported by the Brain Science and Brain-Like Intelligence Technology Program(2021ZD0203003);Beijing National Laboratory for Molecular Sciences(BNLMS202108);the Chinese Academy of Sciences Pioneer Hundred Talents Program.
Drug addiction is a pervasive problem worldwide.It not only affects the abuser’s life,but also poses a serious threat to public health.Accordingly,there is a strong demand for the development of novel and effective t...
关键词：Drug abuse Enzymatic degradation Gene therapy Synthetic biology PHARMACOKINETICS 
Expanding the horizons of targeted protein degradation:A non-small molecule perspective
《Acta Pharmaceutica Sinica B》2024年第6期2402-2427,共26页Xiaowei Huang Fengbo Wu Jing Ye Lian Wang Xiaoyun Wang Xiang Li Gu He 
supported by grants from the National Natural Science Foundation of China(22177084,82273559,82103757 and 82073473);the China Postdoctoral Science Foundation(2022M722283);PostDoctor Research Project,West China Hospital,Sichuan University(2023HXBH076,China);Sichuan Natural Science Foundation Project(2023NSFSC1554,China);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(ZYJC21036,China).
Targeted protein degradation(TPD)represented by proteolysis targeting chimeras(PROTACs)marks a significant stride in drug discovery.A plethora of innovative technologies inspired by PROTAC have not only revolutionized...
关键词：Targeted protein degradation Proteolysis targeting chimera ENDOCYTOSIS Autophagy Proximity-inducing modality Post-translational modification 
Non-small molecule PROTACs(NSM-PROTACs):Protein degradation kaleidoscope被引量：4
《Acta Pharmaceutica Sinica B》2022年第7期2990-3005,共16页Sinan Ma Jianai Ji Yuanyuan Tong Yuxuan Zhu Junwei Dou Xian Zhang Shicheng Xu Tianbao Zhu Xiaoli Xu Qidong You Zhengyu Jiang 
supported by Projects 81773581,82173680 and 81930100 of the National Natural Science Foundation of China;the Priority Academic Program Development of Jiangsu Higher Education Institutions,CPU2018GY02 of Double First Class Innovation Team of China Pharmaceutical University;the Project Program of State Key Laboratory of Natural Medicines,China Pharmaceutical University(No.SKLNMZZ202003);the“Qing Lan”Project of Jiangsu Province;the Young Elite Scientists Sponsorship Program by CAST(No.YESS20180146,China)。
The proteolysis targeting chimeras(PROTACs)technology has been rapidly developed since its birth in 2001,attracting rapidly growing attention of scientific institutes and pharmaceutical companies.At present,a variety ...
关键词：Non-small molecule PROTACs Protein degradation Peptide PROTACs Nucleic acid PROTACs Antibody PROTACs 
6,6’-Bieckol induces apoptosis and suppresses TGF-β-induced epithelial-mesenchymal transition in non-small lung cancer cells
《Chinese Herbal Medicines》2022年第2期254-262,共9页Yongxin Li Man Liu Kunlong Yang Jun Tian 
supported by the National Natural Science Foundation of China(81774228,31972171,31671944);Natural Science Foundation by Xuzhou City(KC21160);the PAPD of Jiangsu Higher Education Institutions,and Scientific Research Support Project for Teachers with Doctor’s Degrees(Jiangsu Normal University,17XLR034)。
Objective:In this study,the aim was to investigate the inhibitory effect of 6,6’-bieckol on the migration and epithelial-mesenchymal transition(EMT)of non-small cell lung cancer(NSCLC)cells,and explore its potential ...
关键词：APOPTOSIS 6 6’-bieckol epithelial-mesenchymal transition migration non-small cell lung cancer PHLOROTANNIN traditional Chinese medicine 
Postoperative radiotherapy in resected non-small cell lung cancer:The never-ending story被引量：1
《World Journal of Clinical Oncology》2021年第10期833-844,共12页Javier Serrano Patricia Calvo Crespo Begoña Taboada Ana Alvarez Gonzalez Rafael Garcia García Antonio Gomez Caamaño Juan Carlos Trujillo Reyes Xabier Mielgo-Rubio Felipe Couñago 
This manuscript collects in a joint and orderly manner the existing evidence at the present time about postoperative treatment with radiotherapy in non-small cell lung cancer.It also systematically reviews the current...
关键词：Non-small lung cancer RADIOTHERAPY POSTOPERATIVE Lung cancer 
Gold Nanoparticles: Synthesis and Effect on Viability of Human Non-Small Lung Cancer Cells
《Advances in Materials Physics and Chemistry》2021年第9期145-153,共9页Rakesh Sharma Yuvraj Singh Negi 
Gold nanoparticles recently showed great interest for many uses including food, drug and medical applications. The algae Undaria
关键词：Brown Algae Undaria sp. Gold Nanoparticles MTT Assay Non-Small Lung Cancer Cells 
Dehydrocostus lactone exerts the antitumor effect in non-small cell lung cancer H1299 cells
《TMR Cancer》2020年第3期101-111,共11页Chao-Yue Su Hui Wang Yan-Rui Pan Ling-Ling Zhang Qiao-Ru Guo Yan-Yan Yan Jia-Jun Li Jia-Li Fu Xin-YueFan Yu-Qing Wang Jian-Ye Zhang 
supported by the National Natural Science Foundation of China(U1903126 and 81903467);Fund of Guangzhou Science and Technology Program(201707010048);Guangdong Basic and Applied Basic Research Foundation(2020A1515010005 and 2020A1515010605);Fund of Undergraduate Innovation Project of Guangzhou Medical University(2019A086).
Background:Dehydrocostus lactone(DHC),a sesquiterpene lactone derived from Aucklandiae Radix,has been proved to possess various pharmacological activities.Recently,studies have reported that DHC has potential antitumo...
关键词：Dehydrocostus LACTONE NON-SMALL cell LUNG cancer Apoptosis MIGRATION INVASION 
Mutation Analysis of EGFR Gene in Patients with Non-Small Cell Lung Cancer in Xinjiang被引量：2
《International Journal of Clinical Medicine》2020年第4期144-153,共10页Yi Shi Xuelian Pang Zhiping Ma Wenli Cui Yuqing Ma Wei Zhang 
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that links extracellular signals to the control of cell survival, growth, proliferation and differentiation. EGFR has been a therapeutic ...
关键词：NON-SMALL Cell LUNG Cancer EGFR MUTATIONS SURVIVAL 
Efficacy and safety of anlotinib plus S-1as thirdly-line or later-line treatmentin advanced non-small cell lung cancer被引量：5
《Oncology and Translational Medicine》2020年第1期10-15,共6页Heng Cao Kai Liang Peng Liu Jing Wang Yuanyuan Ji Lujuan Xu Weilong Wu Shengnan Guo Xuekun Song Yonggui Hong 
Supported by a grant from the Youth National Science Foundation of China(No.61702164)。
Objective Anlotinib,an oral vascular endothelial growth factor receptor 2(VEGFR2)inhibitor,has confirmed antitumor activity in lung cancer in both in vitro and in vivo assays,and has been recommended as third-line tre...
关键词：NON-SMALL cell LUNG cancer(NSCLC) anlotinib TEGAFUR gimerac advanced stage 
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