TAMOXIFEN

作品数：149被引量：250H指数：7
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TMEM132E ablation suppresses tumor progression and restores tamoxifen sensitivity by inducing ERαexpression in triple-negative breast cancer
《Genes & Diseases》2025年第2期37-40,共4页Shang Gao Ping Sun Zekun Wang Yecheng Jin Wenjie Sun Xi Li Ruonan Duan Jiangxia Li Qiji Liu 
supported by grants from the National Key R&D Program of China (No.2022YFC2703701 to Qiji Liu);the National Natural Science Foundation of China (No.82271901,32070586);the Shandong Provincial Natural Science Foundation,China (No.ZR2020MH086);Taishan Scholar Program of Shandong Province (tsqn202211318);NHC Key Laboratory of Birth Defects Prevention,China (No.ZD202101).
Triple-negative breast cancer(TNBC)is defined by the lack of estrogen receptor(ER),progesterone receptor,and amplified human epidermal growth factor receptor expression.TNBC accounts for~15%of all breast cancer cases ...
关键词：expression. BREAST cancer 
Clinical observation of endometrial prescription combined with TAM on FET of thin endometrial patients with kidney deficiency and blood stasis
《Clinical Research Communications》2024年第2期18-22,共5页Wen-Ming Cao Nan Jiang Mei-Hua Wu Xiao-Lei Song Na Yu Shu-Ling Zhang Kui-Mei Zhang 
Shenzhen“Medical and Health Three Projects”Project Grant(SZZYSM 202106003);Shenzhen Bao’an District of Medical and Health Research Project(2023JD212);Shenzhen Bao’an District of Traditional Chinese Medicine Clinical Research Project(2023ZYYLCZX-12);Weifang Health Committee Scientific Research Project(wfwsjk-2023-140).
Objective:To explore the best endometrial preparation scheme of freeze-thawed embryo transfer(FET)for patients with thin endometrium with kidney deficiency and blood stasis by comparing the clinical outcomes of three ...
关键词：endometrium prescription estradiol valerate tablets TAMOXIFEN hormone replacement thin endometrium freeze-thawed embryo transfer 
Breast cancer cell resistance to hormonal and targeted therapeutics is correlated with the inactivation of the NR6A1 axis
《Cancer Drug Resistance》2024年第1期126-141,共16页Olga E.Andreeva Danila V.Sorokin Svetlana V.Vinokurova Pavel B.Kopnin Nadezhda V.Elkina Alexey N.Katargin Radik S.Faskhutdinov Diana I.Salnikova Alexander M.Scherbakov Mikhail A.Krasil’nikov 
supported by the Russian Science Foundation(project No.24-15-00173,https://rscf.ru/project/24-15-00173/).
Aim:Resistance to hormonal and targeted therapies in breast cancer limits treatment efficacy.Epigenetic alterations,including changes mediated by DNA methyltransferases,play a key role in this process.Previously,we id...
关键词：Breast cancer TAMOXIFEN RAPAMYCIN METHYLATION DNMT3A NR6A1 SNAIL estrogen receptorα MCF-7 cells 
Gynecological Side Effects of Tamoxifen among Sudanese Women, Khartoum, Sudan, 2020
《Advances in Breast Cancer Research》2023年第4期152-162,共11页Mawahib Ahmed Elawad Abu Elgasim Yousra Abdelmoniem Suleiman Lobaina Abozaid Dlal Alser Hassan Mohmmed Soha Saad Aldin Mohamad Suliman Duaa Hamd Abdulatif Farh 
Background: In Sudan, the common endocrine therapy tamoxifen is prescribed to HR-positive patients, which is associated with a variety of complications such as hot flashes, vaginal discharge, and vaginal dryness. Obje...
关键词：TAMOXIFEN Breast Cancer Gynecological Side Effects Sudanese Women 
High expression of autophagy-related gene EIF4EBP1 could promote tamoxifen resistance and predict poor prognosis in breast cancer被引量：1
《World Journal of Clinical Cases》2023年第20期4788-4799,共12页Shan Yang Tian-Li Hui Hao-Qi Wang Xi Zhang Yun-Zhe Mi Meng Cheng Wei Gao Cui-Zhi Geng Sai-Nan Li 
BACKGROUND Breast cancer(BC) remains a public health problem. Tamoxifen(TAM) resistance has caused great difficulties for treatment of BC patients. Eukaryotic translation initiation factor 4E binding protein 1(EIF4EBP...
关键词：Breast cancer Eukaryotic translation initiation factor 4E binding protein 1 TAMOXIFEN Resistance Prognosis BIOINFORMATICS 
The effect of natural products combination on MCF-7 cells exceeds tamoxifen therapeutic dose effects in vitro
《BIOCELL》2023年第4期891-904,共14页ZEINAB KLAAB AZIZA HASSAN JAWAHER ALBAQAMI FAIZAH A.ALMALKI 
Researchers Supporting Project No.TURSP-2020/274,Taif University,Taif,Saudi Arabia.
Cancer remains to be one of the most severe sicknesses globally.Cases have kept rising over the years.Breast cancer(BC),which is among the leading types of cancers and predominantly affects women,is the second leading...
关键词：Breast cancer DNA fragmentation APOPTOSIS 
Short-term tamoxifen administration improves hepatic steatosis and glucose intolerance through JNK/MAPK in mice被引量：2
《Signal Transduction and Targeted Therapy》2023年第4期1842-1856,共15页Zhiqiang Fang Hao Xu Juanli Duan Bai Ruan Jingjing Liu Ping Song Jian Ding Chen Xu Zhiwen Li Kefeng Dou Lin Wang 
The National Key Research and Development Program of China(2016YFA0102100,2021YFA1100500);NSFC 81800533,81870430,81422009,81770560。
Nonalcoholic fatty liver disease (NAFLD) which is a leading cause of chronic liver diseases lacks effective treatment. Tamoxifen hasbeen proven to be the first-line chemotherapy for several solid tumors in clinics, ho...
关键词：TAMOXIFEN HEPATIC inflammation 
Adjuvant tamoxifen switched to exemestane treatment in postmenopausal women with estrogen receptor-positive early breast cancer:A pragmatic,multicenter,and prospective clinical trial in China被引量：1
《Chinese Journal of Cancer Research》2022年第6期592-600,共9页Binghe Xu Huiping Li Zefei Jiang Lin Gu Jinhai Tang Hui Xie Yueyin Pan Yunjiang Liu Shude Cui Xiaojia Wang Li Cai Yiqiong Zhang Huadong Zhao Zhimin Shao 
supported by Pfizer Inc。
Objective:This post-approval safety study assessed the efficacy and safety of exemestane after 2-3 years of tamoxifen treatment among postmenopausal women with estrogen receptor-positive(ER+)early breast cancer in Chi...
关键词：Chinese early breast cancer EXEMESTANE TAMOXIFEN postmenopausal women estrogen receptor-positive 
Neonatal feeding of an estrogen receptor β agonist induces external adenomyosis-like lesions in ICR mouse
《Reproductive and Developmental Medicine》2022年第3期144-151,共8页Yun-Lei Cao Xi Wang Xi-Shi Liu Tasuku Harada Sun-Wei Guo 
funded in part by grants 81771553(S.G.),82071623(S.G.),and 81871144(X.L.)from the National Science Foundation of China;an Excellence in Centers of Clinical Medicine grant(2017ZZ01016)from the Science and Technology Commission of Shanghai Municipality;Clinical Research Plan grant SHDC2020CR2062B from Shanghai Shenkang Center for Hospital Development.
Objective:Despite the fact that adenomyosis is a fairly common gynecological disorder,its pathogenesis remains elusive.Several theories on the pathogenesis of adenomyosis have been proposed,but none of them has been p...
关键词：ADENOMYOSIS Estrogen receptor a agonist Estrogen receptorβagonist Mouse model NEONATAL TAMOXIFEN 
Remediation of Hepatotoxic Effect of Tamoxifen with Ginger in Rat Model
《Journal of Pharmacy and Pharmacology》2022年第3期79-86,共8页Vanditha.S Princy Louis Palatty Malini Eapen Thennavan.A Manjeshwar.S.Baliga Greeshma.C.Ravindran 
Background:Tamoxifen is a non-steroidal oestrogen receptor modulator.It has strong anti-estrogenic activity on oestrogen receptor 2 in the breast tissue.It is the treatment of choice in breast cancer cases following s...
关键词：Breast cancer TAMOXIFEN GINGER raised liver enzyme levels HEPATOTOXICITY hepatic sinusoidal congestion 
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