Clinical observation of endometrial prescription combined with TAM on FET of thin endometrial patients with kidney deficiency and blood stasis  

作　　者：Wen-Ming Cao Nan Jiang Mei-Hua Wu Xiao-Lei Song Na Yu Shu-Ling Zhang Kui-Mei Zhang 

机构地区：[1]Gynecology department,Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine,Shenzhen 518104,China [2]Gynecology department,Shandong Maternal and Child Health Hospital,Jinan 2500013,China [3]Gynecology department,Shandong Changle People’s Hospital,Weifang 262400,China.

出　　处：《Clinical Research Communications》2024年第2期18-22,共5页临床研究通讯

基　　金：Shenzhen“Medical and Health Three Projects”Project Grant(SZZYSM 202106003);Shenzhen Bao’an District of Medical and Health Research Project(2023JD212);Shenzhen Bao’an District of Traditional Chinese Medicine Clinical Research Project(2023ZYYLCZX-12);Weifang Health Committee Scientific Research Project(wfwsjk-2023-140).

摘　　要：Objective:To explore the best endometrial preparation scheme of freeze-thawed embryo transfer(FET)for patients with thin endometrium with kidney deficiency and blood stasis by comparing the clinical outcomes of three endometrial preparation schemes of estradiol valerate tablets Hormone Replacement(HRT),Tamoxifen(TAM)and Endometrial Prescription combined with TAM(EP-TAM group).Method:Retrospective analysis of 318 patients with thin endometrium with kidney deficiency and blood stasis who underwent FET in Changle People's Hospital of Shandong Province,Shandong Maternal and Child Health Hospital,and Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine from September 2018 to March 2023,including 101 patients in HRT group(estradiol valerate tablets);108 patients in TAM group;109 patients in EP-TAM group.The cycle cancellation rate,intimal thickness,clinical pregnancy rate,embryo implantation rate,early abortion rate and ectopic pregnancy rate were compared among the three groups.Result:Cycle cancellation rates of TAM group and EP-TAM group were significantly lower than HRT group(8.3%,9.2%vs 17.8%,P<0.05).The intimal thickness of TAM group[(8.11±0.36)mm]and EP-TAM group[(8.21±0.40)mm]was significantly thicker than HRT group[(7.11±0.43)mm](P<0.05).The clinical pregnancy rate and implantation rate of TAM group and EP-TAM group were higher than HRT group,the early abortion rate and ectopic pregnancy rate were lower than HRT group,and EP-TAM group was more significant(P<0.05).Conclusion:Patients with thin endometrium underwent FET can try Endometrium Prescription combined with TAM(EP-TAM)to prepare the endometrium.

关 键 词：endometrium prescription estradiol valerate tablets TAMOXIFEN hormone replacement thin endometrium freeze-thawed embryo transfer 

分 类 号：R73[医药卫生—肿瘤]