RAPAMYCIN

作品数：252被引量：885H指数：14
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相关作者：程元荣谢淑丽王广义金娟王亚柱更多>>
相关机构：山东大学浙江省人民医院浙江大学复旦大学更多>>
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Rapamycin as a preventive intervention for Alzheimer’s disease in APOE4 carriers:Targeting brain metabolic and vascular restoration
《Neural Regeneration Research》2026年第2期685-686,共2页Ai-Ling Lin Chetan Aware 
supported by National Institute on Aging(NIH-NIA)R01AG054459(to ALL).
Alzheimer’s disease(AD)is the most common form of dementia,affecting over 50 million people worldwide.This figure is projected to nearly double every 20 years,reaching 82 million by 2030 and 152 million by 2050(Alzhe...
关键词：lipid transporterexists Dementia alzheimer s disease ad RAPAMYCIN Brain metabolic Vascular restoration Amyloid beta plaques APOE 
Rapamycin suppresses rheumatoid arthritis fibroblast synovial cell proliferation and induces apoptosis via the AKT/mTORC1 pathway
《Rheumatology & Autoimmunity》2024年第3期156-164,共9页Shengxiao Zhang Xiaorong Hu Qinyi Su Heyi Zhang Ting Cheng Jia Wang Ruomeng Pei Xin Li Ruqi Zhang Hongfang Shao Caihong Wang Xiaofeng Li 
National Science Foundation of China,Grand/Award Number:82001740;Natural Science Foundation of Shanxi Province,Grand/Award Number:202203021221269。
Background:Rheumatoid arthritis(RA)is an autoimmune disease characterized by the overproliferation of synovial fibroblast-like synoviocytes(FLSs)in the lining,leading to chronic inflammation and progressive joint dama...
关键词：APOPTOSIS mTORC1 RAPAMYCIN rheumatoid arthritis synovial fibroblasts 
Rapamycin Potentiates the Antitumor Effect of 5-Fluorouracil in Colon Cancer by Enhancing Autophagy
《Journal of Clinical and Nursing Research》2024年第7期152-160,共9页Xiaoming Tian Youjun He Tao Hao 
Objective:To investigate whether the mTOR inhibitor rapamycin can enhance the growth suppression effect of 5-fluorouracil(5-FU)on colon cancer cells.Methods:CCK8 assays were used to examine cell survival.Flow cytometr...
关键词：Colorectal cancer Proliferation Apoptosis AUTOPHAGY RAPAMYCIN 
Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C.elegans
《Journal of Genetics and Genomics》2024年第5期507-516,共10页Xiao Zang Qi Wang Hanxin Zhang Yiyan Zhang Zi Wang Zixing Wu Di Chen 
the National Key R&D Program of China(2021YFA0805802 to D.C.);the National Natural Science Foundation of China(31971092 and 32171156 to D.C.);Some strains were provided by the Caenorhabditis Genetics Center(CGC),which is funded by NIHOffice of Research Infrastructure Programs(P40 OD010440).
The highly conserved target of rapamycin(TOR)pathway plays an important role in aging across species.Previous studies have established that inhibition of the TOR complex 1(TORC1)significantly extends lifespan in Caeno...
关键词：Aging targetof rapamycin DAF-15 DAF-16 C.elegans 
Breast cancer cell resistance to hormonal and targeted therapeutics is correlated with the inactivation of the NR6A1 axis
《Cancer Drug Resistance》2024年第1期126-141,共16页Olga E.Andreeva Danila V.Sorokin Svetlana V.Vinokurova Pavel B.Kopnin Nadezhda V.Elkina Alexey N.Katargin Radik S.Faskhutdinov Diana I.Salnikova Alexander M.Scherbakov Mikhail A.Krasil’nikov 
supported by the Russian Science Foundation(project No.24-15-00173,https://rscf.ru/project/24-15-00173/).
Aim:Resistance to hormonal and targeted therapies in breast cancer limits treatment efficacy.Epigenetic alterations,including changes mediated by DNA methyltransferases,play a key role in this process.Previously,we id...
关键词：Breast cancer TAMOXIFEN RAPAMYCIN METHYLATION DNMT3A NR6A1 SNAIL estrogen receptorα MCF-7 cells 
Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis被引量：1
《Acta Pharmaceutica Sinica B》2024年第3期1380-1399,共20页Yixian Li Peng Yang Ran Meng Shuting Xu Lingling Zhou Kang Qian Pengzhen Wang Yunlong Cheng Dongyu Sheng Minjun Xu Tianying Wang Jing Wu Jinxu Cao Qizhi Zhang 
supported by National Natural Science Foundation of China(Nos.82073780 and 82273868,China);Shanghai Municipal Natural Science Foundation(No.19ZR1406200,China)。
Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer’s disease(AD)collectively culminate in neuronal deterioration.In the context of AD,autophagy dysfunction,a multi-link obst...
关键词：Autophagy-lysosome pathway Alzheimer’s disease PROTEOSTASIS Neuroinflammation Multi-target therapy RAPAMYCIN Gypenoside XVII Cascade dual-targeting 
Rapamycin restores CD4^(+)T cell subsets imbalance in Graves' ophthalmopathy mice model
《China Medical Abstracts(Internal Medicine)》2024年第1期29-30,共2页张萌 
Objective To study the effect of rapamycin on the disorder of CD4^(+)T cell subsets in Graves’ophthalmopathy (GO) mice,as well as the ophthalmopathy and hyperthyroidism phenotype,and to provide new possibilities for ...
关键词：GRAVES RAPAMYCIN EXPRESSING 
Overcoming adaptive resistance in AML by synergistically targeting FOXO3A-GNG7-mTOR axis with FOXO3A inhibitor Gardenoside and rapamycin被引量：2
《Genes & Diseases》2024年第1期397-412,共16页Zhe Chen Qian Guo Shichen Huang Lei Li Feng Wu Zhilong Liu Zhigang Li Tao Chen Guanbin Song Shuangnian Xu Jieping Chen Yu Hou 
supported by the Chongqing Science Fund for Distinguished Young Scholars,China(C(STB2022NSCQJQX0032);National Science Foundation of China(No.81970100,82170115 and 81700135);the Doctor Research Project of Chongqing,China(No.CSTB2022BSXMJCX0005)。
Therapeutic targeting FOxO3A(a forkhead transcription factor)represents a prom-ising strategy to suppress acute myeloid leukemia(AML).However,the effective inhibitors that target FOXO3A are lacking and the adaptive re...
关键词：AML Combinatorial inhibition FOXO3A GNG7 MTOR 
Rapamycin reverses ferroptosis by increasing autophagy in MPTP/MPP+-induced models of Parkinson's disease被引量：11
《Neural Regeneration Research》2023年第11期2514-2519,共6页Tongyu Liu Peihan Wang Huan Yin Xiangfei Wang Jing Lv Jiang Yuan Jing Zhu Yunfu Wang 
Parkinson’s disease is a neurodegenerative disorder,and fe rroptosis plays a significant role in the pathological mechanism underlying Parkinson’s disease.Rapamycin,an autophagy inducer,has been shown to have neurop...
关键词：AUTOPHAGY behavior ferroptosis MPTP Parkinson’s disease PC12 cell RAPAMYCIN tyrosine hydroxylase 
LncRP11-675F6.3 responds to rapamycin treatment and reduces triglyceride accumulation via interacting with HK1 in hepatocytes by regulating autophagy and VLDL-related proteins
《Acta Biochimica et Biophysica Sinica》2023年第10期1606-1617,共12页Lingling Wang Xiaojuan Fang Ziyou Yang Xueling Li Mengdi Cheng Liang Cheng Ganglin Wang Wei Li Lin Liu 
supported by the grants from the National Natural Science Foundation of China(No.81970753);the Wenzhou Science and Technology Bureau Foundation(No.ZY2021011).
Long noncoding RNAs(lncRNAs)have been widely proven to be involved in liver lipid homeostasis.Herein,we identify an upregulated lncRNA named lncRP11-675F6.3 in response to rapamycin treatment using a microarray in Hep...
关键词：lncRP11-675F6.3 TRIGLYCERIDES AUTOPHAGY LIPOPROTEIN hexokinase 1 nonalcoholic fatty liver disease 
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