PROTEOSTASIS

作品数：35被引量：95H指数：5
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相关作者：陈一萌李唐郭娣王国林王海云更多>>
相关机构：天津医科大学更多>>
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Proteostasis failure:at the intersection between aging and Alzheimer's disease
《Neural Regeneration Research》2025年第11期3221-3222,共2页Natalia Poblete Claudio Hetz 
funded by U.S.Air Force Office of Scientific Research FA9550-21-1-0096,FONDAP program 15150012,ANID/FONDEF ID1ID22I10120,FONDECY/ANID 1220573;the US Army Medical Research Acquisition Activity(USAMRAA)project number AL2201415;DoD Award HT9425-23-1-0990,AL220141(to CH)。
Lifestyle and demographics of the world's population are causing serious health problems impacting the brain,increasing the incidence of Alzheimer's disease(AD)and other types of dementia.Although we have gained impor...
关键词：ALZHEIMER AMYLOID STASIS 
Targeting chaperone-mediated autophagy in neurodegenerative diseases:mechanisms and therapeutic potential
《Acta Pharmacologica Sinica》2025年第4期816-828,共13页Jin Wu Wan Xu Ying Su Guang-hui Wang Jing-jing Ma 
supported by the National Natural Science Foundation of China(grants 32400789 and 32070970);the Natural Science Foundation of Jiangsu Province(grants BK20240436);the Suzhou Science and Technology Development Plan(SZM2023006 and SKYD2023179);the Gusu Key Health Talent Program of Suzhou(GSWS2022122).
The pathological hallmarks of various neurodegenerative diseases including Parkinson’s disease and Alzheimer’s disease prominently feature the accumulation of misfolded proteins and neuroinflammation.Chaperone-media...
关键词：neurodegenerative diseases chaperone-mediated autophagy neuronal proteostasis NEUROINFLAMMATION CMA modulators 
Lung Single-Cell Transcriptomics Offers Insights into the Pulmonary Interstitial Toxicity Caused by Silica Nanoparticles
《Environment & Health》2024年第11期786-801,共16页Yan Li Qing Yao Hailin Xu Jiaze Ren Yurou Zhu Caixia Guo Yanbo Li 
supported by the National Natural Science Foundation of China(82273658,82173551);Special Funds for the Construction of High-level Public Health Technical Talents(xuekegugan-01-048).
The adverse respiratory outcomes motivated by silica nanoparticles(SiNPs)exposure have received increasing attention.Herein,we aim to elucidate the interplay of diverse cell populations in the lungs and key contributo...
关键词：silica nanoparticles single-cell RNA-Seq lung toxicity lung interstitial disease PROTEOSTASIS 
CRL2^(APPBP2)-mediated TSPYL2 degradation counteracts human mesenchymal stem cell senescence被引量：3
《Science China(Life Sciences)》2024年第3期460-474,共15页Daoyuan Huang Qian Zhao Kuan Yang Jinghui Lei Ying Jing Hongyu Li Chen Zhang Shuai Ma Shuhui Sun Yusheng Cai Guibin Wang Jing Qu Weiqi Zhang Si Wang Guang-Hui Liu 
supported by the National Key Research and Development Program of China(2020YFA0804000,2022YFA1103700,2020YFA0112200,2021YFF1201000,the STI2030-Major Projects-2021ZD0202400,2022YFA1103800);the National Natural Science Foundation of China(82201714,81921006,82125011,92149301,92168201,91949209,92049304,92049116,32121001,82192863,82122024,82071588,32000500,82271600,82001477,82201727);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16000000);CAS Project for Young Scientists in Basic Research(YSBR-076,YSBR-012);the Program of the Beijing Natural Science Foundation(Z190019);the Fellowship of China Postdoctoral Science Foundation(2022M712216);the Project for Technology Development of Beijing-affiliated Medical Research Institutes(11000023T000002036310);the Pilot Project for Public Welfare Development and Reform of Beijing-affiliated Medical Research Institutes(11000022T000000461062);Youth Innovation Promotion Association of CAS(E1CAZW0401,2022083,2023092);Young Elite Scientists Sponsorship Program by CAST(YESS20200012,YESS20210002);the Informatization Plan of Chinese Academy of Sciences(CAS-WX2021SF-0301,CAS-WX2022SDC-XK14,CASWX2021SF-0101);New Cornerstone Science Foundation through the XPLORER PRIZE(2021-1045);Excellent Young Talents Program of Capital Medical University(12300927);Excellent Young Talents Training Program for the Construction of Beijing Municipal University Teacher Team(BPHR202203105);Beijing Hospitals Authority Youth Programme(QML20230806)。
Cullin-RING E3 ubiquitin ligases(CRLs),the largest family of multi-subunit E3 ubiquitin ligases in eukaryotic cells,represent core cellular machinery for executing protein degradation and maintaining proteostasis.Here...
关键词：Cullins stem cell SENESCENCE AGING PROTEOSTASIS UBIQUITINATION APPBP2 TSPYL2 
Multidimensional autophagy nano-regulator boosts Alzheimer's disease treatment by improving both extra/intraneuronal homeostasis被引量：1
《Acta Pharmaceutica Sinica B》2024年第3期1380-1399,共20页Yixian Li Peng Yang Ran Meng Shuting Xu Lingling Zhou Kang Qian Pengzhen Wang Yunlong Cheng Dongyu Sheng Minjun Xu Tianying Wang Jing Wu Jinxu Cao Qizhi Zhang 
supported by National Natural Science Foundation of China(Nos.82073780 and 82273868,China);Shanghai Municipal Natural Science Foundation(No.19ZR1406200,China)。
Intraneuronal dysproteostasis and extraneuronal microenvironmental abnormalities in Alzheimer’s disease(AD)collectively culminate in neuronal deterioration.In the context of AD,autophagy dysfunction,a multi-link obst...
关键词：Autophagy-lysosome pathway Alzheimer’s disease PROTEOSTASIS Neuroinflammation Multi-target therapy RAPAMYCIN Gypenoside XVII Cascade dual-targeting 
Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants被引量：1
《Acta Pharmacologica Sinica》2024年第2期282-297,共16页Pei-pei Zhang Taylor M.Benske Lucie Y.Ahn Ashleigh E.Schaffer James C.Paton Adrienne W.Paton Ting-wei Mu Ya-juan Wang 
supported by the National Institutes of Health(R01NS117176 to TWM,R01NS123524 to AES,and F30HD110088 to LYA);the Brain Research Foundation(BRFSG-2021-08 to AES).
The GRIN genes encoding N-methyl-D-aspartate receptor(NMDAR)subunits are remarkably intolerant to variation.Many pathogenic NMDAR variants result in their protein misfolding,inefficient assembly,reduced surface expres...
关键词：NMDA receptors endoplasmic reticulum unfolded protein response PROTEOSTASIS EPILEPSY CHANNELOPATHY 
Metabolic and proteostatic differences in quiescent and active neural stem cells被引量：1
《Neural Regeneration Research》2024年第1期43-48,共6页Jiacheng Yu Gang Chen Hua Zhu Yi Zhong Zhenxing Yang Zhihong Jian Xiaoxing Xiong 
supported by the National Natural Science Foundation of China,No.82171336(to XX)。
Adult neural stem cells are neurogenesis progenitor cells that play an important role in neurogenesis.Therefore,neural regeneration may be a promising target for treatment of many neurological illnesses.The regenerati...
关键词：adult neurogenesis cell metabolic pathway cellular proliferation neural stem cell niches neural stem cells neuronal differentiation nutrient sensing pathway PROTEOSTASIS 
Decoding the proteostasis network in resistance to KRAS inhibitors
《The Innovation》2023年第6期7-8,共2页Xinxin Song Zhuan Zhou Kenneth D.Westover 
We thank Dave Primm(Department of Surgery,University of Texas Southwestern Med-ical Center)for his critical reading of the manuscript.X.S.was supported by an American Cancer Society grant(RG-21-142-16);National Institutes of Health grant(P30CA142543);Simmons Comprehensive Cancer Center and is supported by a startup fund bythe Department of Surgery at the University of Texas Southwestem Medical Center.K.D.W.is supported by grants from the National Institutes of Health(R01 CA244341);Cancer Prevention and Research Institute of Texas(RP220145).
The Kirsten rat sarcoma(KRAS)gene,which is one of the most frequently mutated genes in human cancers,has long captured the attention of oncologists.The recent approval of KRAS G12C inhibitors(KRASi),such as sotorasib ...
关键词：KRAS RESISTANCE NETWORK 
Myelinosome organelles in pathological retinas: ubiquitous presence and dual role in ocular proteostasis maintenance被引量：1
《Neural Regeneration Research》2023年第5期1009-1016,共8页Marina G.Yefimova 
The timely and efficient elimination of aberrant proteins and damaged organelles, formed in response to various genetic and environmental stressors, is a vital need for all cells of the body. Recent lines of evidence ...
关键词：autophagy Huntington’s disease Müller cells myelinosome-driven secretion myelinosomes ocular pathophysiology PROTEOSTASIS retina retinal pigmented epithelium ubiquitin-proteasome system 
Coaggregation of polyglutamine(polyQ)proteins is mediated by polyQ-tract interactions and impairs cellular proteostasis
《Acta Biochimica et Biophysica Sinica》2023年第5期736-748,共13页Jun-Ye Hong Jian-Yang Wang Hong-Wei Yue Xiang-Le Zhang Shu-Xian Zhang Lei-Lei Jiang Hong-Yu Hu 
supported by the grants from the National Natural Science Foundation of China(Nos.31470758 and 31870764).
Nine polyglutamine(polyQ)proteins have already been identified that are considered to be associated with the pathologies of neurodegenerative disorders called polyQ diseases,but whether these polyQ proteins mutually i...
关键词：POLYGLUTAMINE COAGGREGATION protein interaction PROTEOSTASIS SEQUESTRATION 
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