Proteostasis failure:at the intersection between aging and Alzheimer's disease  

作　　者：Natalia Poblete Claudio Hetz 

机构地区：[1]Center for Geroscience,Brain Health and Metabolism,Santiago,Chile [2]Biomedical Neuroscience Institute,Faculty of Medicine,University of Chile,Santiago,Chile [3]Program of Cellular and Molecular Biology,Institute of Biomedical Sciences,Faculty of Medicine,University of Chile,Santiago,Chile [4]Buck Institute for Research on Aging,Novato,CA,USA

出　　处：《Neural Regeneration Research》2025年第11期3221-3222,共2页中国神经再生研究（英文版）

基　　金：funded by U.S.Air Force Office of Scientific Research FA9550-21-1-0096,FONDAP program 15150012,ANID/FONDEF ID1ID22I10120,FONDECY/ANID 1220573;the US Army Medical Research Acquisition Activity(USAMRAA)project number AL2201415;DoD Award HT9425-23-1-0990,AL220141(to CH)。

摘　　要：Lifestyle and demographics of the world's population are causing serious health problems impacting the brain,increasing the incidence of Alzheimer's disease(AD)and other types of dementia.Although we have gained important insights into the pathogenic mechanisms of AD,only palliative care is available to patients.AD is characterized by the abnormal deposition of protein aggregates in the brain formed by amyloid β and hyper-phosphorylated,Tau in addition to neuroinflammation.

关 键 词：ALZHEIMER AMYLOID STASIS 

分 类 号：R749.16[医药卫生—神经病学与精神病学]