TMEM132E ablation suppresses tumor progression and restores tamoxifen sensitivity by inducing ERαexpression in triple-negative breast cancer  

作　　者：Shang Gao Ping Sun Zekun Wang Yecheng Jin Wenjie Sun Xi Li Ruonan Duan Jiangxia Li Qiji Liu 

机构地区：[1]Key Laboratory for Experimental Teratology of the Ministry of Education,Department of Medical Genetics,School of Basic Medical Sciences,Cheeloo College of Medicine,Shandong University,Jinan,Shandong 250012,China [2]Department of Neurology,Qilu Hospital of Shandong University,Jinan,Shandong 250012,China [3]Key Laboratory for Experimental Teratology of the Ministry of Education and Department of Medical Genetics,School of Basic Medical Sciences,Shandong University,School of Health and Life Sciences,University of Health and Rehabilitation Sciences,Qingdao,Shandong 266071,China [4]NHC Key Laboratory of Birth Defects Prevention,Institute of Reproductive Health,Henan Academy of Innovations in Medical Science,Zhengzhou,Henan 451163,China

出　　处：《Genes & Diseases》2025年第2期37-40,共4页基因与疾病(英文)

基　　金：supported by grants from the National Key R&D Program of China (No.2022YFC2703701 to Qiji Liu);the National Natural Science Foundation of China (No.82271901,32070586);the Shandong Provincial Natural Science Foundation,China (No.ZR2020MH086);Taishan Scholar Program of Shandong Province (tsqn202211318);NHC Key Laboratory of Birth Defects Prevention,China (No.ZD202101).

摘　　要：Triple-negative breast cancer(TNBC)is defined by the lack of estrogen receptor(ER),progesterone receptor,and amplified human epidermal growth factor receptor expression.TNBC accounts for~15%of all breast cancer cases but represents>50%of breast cancer(BC)-related mortalities.

关 键 词：expression. BREAST cancer 

分 类 号：R73[医药卫生—肿瘤]