Remediation of Hepatotoxic Effect of Tamoxifen with Ginger in Rat Model  

作　　者：Vanditha.S Princy Louis Palatty Malini Eapen Thennavan.A Manjeshwar.S.Baliga Greeshma.C.Ravindran 

机构地区：[1]Department of Pharmacology,Amrita School of Medicine,Amrita Vishwa Vidyapeetham,Kochi,India [2]Department of Pathology,Amrita School of Medicine,Amrita Vishwa Vidyapeetham,Kochi,India [3]Veterinary Medicine Department,Amrita School of Medicine,Amrita Vishwa Vidyapeetham,Kochi,India [4]Mangalore Institute Of Oncology,Mangalore,India [5]Department of Biostatistics,Amrita School of Medicine,Amrita Vishwa Vidyapeetham,Kochi,India

出　　处：《Journal of Pharmacy and Pharmacology》2022年第3期79-86,共8页药剂与药理学（英文版）

摘　　要：Background:Tamoxifen is a non-steroidal oestrogen receptor modulator.It has strong anti-estrogenic activity on oestrogen receptor 2 in the breast tissue.It is the treatment of choice in breast cancer cases following surgery and radiotherapy,it is the most potent weapon against breast cancer.All stages of hormone-dependent breast cancer are currently treated with tamoxifen.Long-term tamoxifen therapy may cause hepatotoxicity which would perclude the use of tamoxifen.Hence this study was done to determine whether ginger has a role in protecting liver toxicity caused by tamoxifen.Methods:Twenty female albino rats(SD)were divided into 4 groups.Each group formed of five rats:Group I:Serves as control group received normal rodent diet and water,GroupⅡ:Received ginger powder(200 mg/kg)dissolved in normal saline,orally daily for 6 weeks,GroupⅢ:received TAM at a dose of 20 mg/kg daily for 6 weeks orally GroupⅣ:Received TAM(20 mg/kg)then after 2 hrs they are orally given Ginger powder(200 mg/kg)daily for 6 weeks.Results:Tamoxifen 20 mg/kg/day caused hepatotoxicity in rats.When ginger is added to tamoxifen there is no development of hepatotoxic features like:marked sinusoidal congestion in the lobules and lab parameters showed decrease in serum AST and ALT levels when compared to tamoxifen group levels.Conclusion:Ginger supplementation would reduce the incidence of hepatotoxicity&related adverse drug reactions among breast cancer patient on therapy.

关 键 词：Breast cancer TAMOXIFEN GINGER raised liver enzyme levels HEPATOTOXICITY hepatic sinusoidal congestion 

分 类 号：R73[医药卫生—肿瘤]