CISPLATIN

作品数：604被引量：1584H指数：17
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相关作者：曾慧慧王夔卢仁泉郭林李强更多>>
相关机构：华中科技大学四川大学北京大学卫生部更多>>
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Idarubicin-transarterial chemoembolization combined with gemcitabine plus cisplatin for unresectable intrahepatic cholangiocarcinoma
《World Journal of Gastrointestinal Oncology》2025年第4期81-92,共12页Cheng-Hao Zhao Huan Liu Tao Pan Zhan-Wang Xiang Lu-Wen Mu Jun-Yang Luo Chu-Ren Zhou Ming-An Li Ming-Ming Liu Hu-Zheng Yan Ming-Sheng Huang 
Supported by the Guangzhou Science and Technology Plan Project,No.2023A04J0419;National Natural Science Foundation Cultivation Project at the Third Affiliated Hospital of Sun Yat-sen University,No.2022GZRPYQN04.
BACKGROUND Intrahepatic cholangiocarcinoma(iCCA)is the second most common liver malignancy with poor prognosis and limited treatment options.AIM To identify the most effective drug for transarterial chemoembolization(...
关键词：Transarterial chemoembolization Intrahepatic cholangiocarcinoma GEMCITABINE CISPLATIN IDARUBICIN 
Intraperitoneal perfusion of endostatin improves the effectiveness and prolongs the prognosis of patients with gastric cancer
《World Journal of Gastrointestinal Oncology》2025年第4期223-232,共10页Yong Liu Hong-Gen Liu Cheng Zhao 
Supported by Scientific Research Project of Tianjin Municipal Education Commission,No.2018KJ015.
BACKGROUND Studies on the application of recombinant human endostatin(RH-endostatin)intraperitoneal perfusion in gastric cancer(GC)with malignant ascites are limited.AIM To explore the effectiveness,prognosis,and safe...
关键词：Gastric cancer Recombinant human endostatin Peritoneal metastasis Malignant ascites CISPLATIN Efficacy PROGNOSIS 
Cisplatin induces acute liver injury by triggering caspase-3/GSDME-me diate d cell pyroptosis
《Hepatobiliary & Pancreatic Diseases International》2025年第2期177-187,共11页Ping-Ping Wu Xiu-Jin Shen Shu-Sen Zheng 
supported by grants from the National Natural Science Foundation of China(8170060495 and 82170682)。
Background:Cisplatin triggers Gasdermin E(GSDME)cleavage,causing membrane bubble formation,content release,and inflammation.Caspase-3 activation initiates GSDME cleavage,and thus inhibiting this pathway mitigates cisp...
关键词：CISPLATIN PYROPTOSIS HEPATOTOXICITY Gasdermins GSDME 
COPB2 promotes hepatocellular carcinoma progression through regulation of YAP1 nuclear translocation
《Oncology Research》2025年第4期975-988,共14页BIAO WU XIANLIN GUO ZHISHI WU LIANG CHEN SUQING ZHANG 
Objectives:Although Yes-associated protein 1(YAP1)is an important oncogene in hepatocellular carcinoma(HCC)progression,its nuclear localization prevents it from being considered a potential therapeutic target.Recently...
关键词：Coatomer protein complex subunit beta 2(COPB2) Yes-associated protein 1(YAP1) Hepatocellular carcinoma(HCC)prognosis Cisplatin(DDP) 
TanshinoneⅡA Facilitates Chemosensitivity of Osteosarcoma Cells to Cisplatin via Activation of p38 MAPK Pathway
《Chinese Journal of Integrative Medicine》2025年第4期326-335,共10页XIE Da-ming LI Zhi-yun REN Bing-kai GONG Rui YANG Dong HUANG Sheng 
Supported by the Jiangxi Provincial Natural Science Foundation(No.20224ACB206009)。
Objective:To examine the mechanism of action of tanshinoneⅡA(TanⅡA)in promoting chemosensitization of osteosarcoma cells to cisplatin(DDP).Methods:The effects of different concentrations of TanⅡA(0–80μmol/L)and D...
关键词：OSTEOSARCOMA CISPLATIN tanshinone II A P38 MAPK Chinese medicine 
Inhibition of the cGAS‑STING Pathway Reduces Cisplatin‑Induced Inner Ear Hair Cell Damage
《Neuroscience Bulletin》2025年第3期359-373,共15页Ying Sun Shengyu Zou Xiaoxiang Xu Shan Xu Haiying Sun Mingliang Tang Weijia Kong Xiong Chen Zuhong He 
supported by grants from the National Natural Science Foundation of China(82222017,82271183,and 81970883);the Key Research and Development Program of Hubei Province(2022BCA046);funding from the Fundamental Research Funds for the Central Universities(2042022kf0059).
Although cisplatin is a widely used chemotherapeutic agent,it is severely toxic and causes irreversible hearing loss,restricting its application in clinical settings.This study aimed to determine the molecular mechani...
关键词：OTOTOXICITY Hearing loss cGAS-STING Hair cell Mitochondrial dysfunction 
Therapeutic potential of kakkatin derivatives against hepatocellular carcinoma
《World Journal of Clinical Oncology》2025年第3期13-19,共7页Sahiba Chahal Vikram Patial 
Supported by the Indian Council of Scientific and Industrial Research,No.MLP0204(CSIR-IHBT no.5712).
In this article,we commented on the work done by Jiang et al,where they syn-thesized a kakkatin derivative,6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-me-thoxy-4H-chromen-4-one(HK),and investigated its antitumor activ...
关键词：Hepatocellular carcinoma ANTITUMOR Kakkatin PROTOONCOGENES CISPLATIN 
Corrigendum to:HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells
《Acta Biochimica et Biophysica Sinica》2025年第2期326-326,共1页Xinxin Kou Xiaoxia Yang Zheng Zhao Lei Li 
Acta Biochim Biophys Sin 2024,56(3):356–365 https://doi.org/10.3724/abbs.2023246 In the originally published version of this article,the Author′s affiliation was set incorrectly.This has now been corrected,and the a...
关键词：Cancer COR CISPLATIN 
hUCMSC-derived extracellular vesicles relieve cisplatin-induced granulosa cell apoptosis in mice by transferring antiapoptotic miRNAs
《Journal of Biomedical Research》2025年第1期36-49,共14页Wenjing Tang Haiyan Yan Xiaojun Chen Yanan Pu Xin Qi Liyang Dong Chuan Su 
Financial support for the current study was provided by the grant from"Blue Engineering"Excellent Young Teacher Foundation in Colleges and Universities of Jiangsu Province(Grant No.KY101R202207 to Xiaojun Chen)。
Premature ovarian insufficiency(POI)caused by chemotherapy is a common complication in female cancer survivors of childbearing age.Traditional methods,including mesenchymal stem cell(MSC)transplant and hormone replace...
关键词：CHEMOTHERAPY fertility preservation extracellular vesicles granulosa cell apoptosis microRNAs 
Prophylactic hyperthermic intraperitoneal chemotherapy in patients with locally advanced gastric cancer after curative surgery:Final results of a phase Ⅱ trial
《Chinese Journal of Cancer Research》2025年第1期66-72,共7页Biao Fan Hao Su Lingqian Wang Xin Ji Yinan Zhang Ziyu Jia Ji Zhang Zhaode Bu Xiaojiang Wu 
supported by the National Nature Science Foundation of China(No.81402308);Science Foundation of Peking University Cancer Hospital(No.2021-24);Natural Science Foundation of Beijing Municipal(No.7242020);Science Foundation of Peking University Cancer Hospital(No.BJCH2025GG04);the National Nature Science Foundation of China(No.82173151).
Objective:The trial was designed to evaluate the efficacy of prophylactic hyperthermic intraperitoneal chemotherapy(HIPEC)with cisplatin for patients with locally advanced gastric cancer(LAGC).Methods:Between March 20...
关键词：Gastric cancer intraperitoneal chemotherapy CISPLATIN PROGNOSIS 
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