ANTITUMOR

作品数：469被引量：1197H指数：15
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相关机构：北京大学天津医科大学中国药科大学福建省亚热带植物研究所更多>>
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Pharmacological role of Herba Patriniae and Coix seed in colorectal cancer
《World Journal of Gastrointestinal Oncology》2025年第3期1-8,共8页Yu-Xin Zhang Hui Wan Guan-Yue Shan Jun-Ya Cheng Yi-Ying Liu Wen-Na Shi Hai-Jun Li 
National Natural Science Foundation of China,No.81970529;The Natural Science Foundation of Jilin Province,No.20230508074RC and No.YDZJ202401218ZYTS.
Colorectal cancer(CRC)is the most prevalent cancer globally,and its traditional treatment modalities commonly encompass radiation therapy,chemotherapy,surgery and the administration of cytotoxic drugs.Currently,novel ...
关键词：Colorectal cancer Herba Patriniae Coix seed ANTITUMOR Chinese medicine 
Review of Astragalus membranaceus polysaccharides:Extraction process,structural features,bioactivities and applications
《Chinese Herbal Medicines》2025年第1期56-69,共14页Hongyue Tian Lingzhuo An Pengwang Wang Xuemin Zhang Wenyuan Gao Xia Li 
supported by Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202005);Key project at central government level(No.2060302);National Natural Science Foundation of China(No.81872956);Special Project for Transformation of Scientific and Technological Achievements in Qinghai Province(No.2021-SF-150)。
Astragalus membranaceus possesses the function of enhancing immunity,protecting the liver,diuretic,anti-aging,anti-stress,anti-hypertensive,and more extensive antibacterial effects.Polysaccharides,one kind of the majo...
关键词：antidiabetic activity ANTITUMOR APPLICATIONS Astragalus membranaceus(Fisch.)Bge. Astragalus membranaceus polysaccharides extraction process IMMUNOMODULATION structure-activity relationship 
Therapeutic potential of kakkatin derivatives against hepatocellular carcinoma
《World Journal of Clinical Oncology》2025年第3期13-19,共7页Sahiba Chahal Vikram Patial 
Supported by the Indian Council of Scientific and Industrial Research,No.MLP0204(CSIR-IHBT no.5712).
In this article,we commented on the work done by Jiang et al,where they syn-thesized a kakkatin derivative,6-(hept-6-yn-1-yloxy)-3-(4-hydroxyphenyl)-7-me-thoxy-4H-chromen-4-one(HK),and investigated its antitumor activ...
关键词：Hepatocellular carcinoma ANTITUMOR Kakkatin PROTOONCOGENES CISPLATIN 
Endoplasmic reticulum membrane remodeling by targeting reticulon-4 induces pyroptosis to facilitate antitumor immune
《Protein & Cell》2025年第2期121-135,共15页Mei-Mei Zhao Ting-Ting Ren Jing-Kang Wang Lu Yao Ting-Ting Liu Ji-Chao Zhang Yang Liu Lan Yuan Dan Liu Jiu-Hui Xu Peng-Fei Tu Xiao-Dong Tang Ke-Wu Zeng 
financially supported by National Natural Sciences Foundation of China(82325050);National Key R&D Program of China(2022YFC3501601);Beijing Municipal Natural Science Foundation(7232273);Jinan New 20 Policies for Higher Education Funding(202228048);Natural Science Foundation of Shandong Province(Joint Foundation for Innovation and Development)(ZR2022LZY021)。
Pyroptosis is an identified programmed cell death that has been highly linked to endoplasmic reticulum(ER)dynamics.However,the crucial proteins for modulating dynamic ER membrane curvature change that trigger pyroptos...
关键词：PYROPTOSIS ER membrane antitumor immune OSTEOSARCOMA chemical degrader reticulon-4(RTN4) 
Research Progress of Chinese Medicine Monomers in Treatment of Cholangiocarcinoma
《Chinese Journal of Integrative Medicine》2025年第2期170-182,共13页WANG Xiang WANG Xiao-qing LUO Kai BAI He QU Jia-lin ZHANG Gui-xin 
Supported by the Grants from the National Natural Science Foundation of China(No.82174136);Dalian Medical University Intensified Program of Wellness Interdisciplinary Research Cooperation Project Team Funding(No.JCHZ2023004)。
Cholangiocarcinoma(CCA)is a malignant tumor originating from cholangiocytes.However,it remains unclear about the pathogenesis of this carcinoma,which may be related to multiple factors.Currently,CCA is mainly treated ...
关键词：CHOLANGIOCARCINOMA Chinese medicine MONOMERS ANTITUMOR signaling pathways molecular mechanisms REVIEW 
Peptide-based strategies for overcoming multidrug-resistance in cancer therapy
《Chinese Chemical Letters》2025年第1期110-118,共9页Xiaofang Luo Ye Wu Xiaokun Zhang Min Tang Feiye Ju Zuodong Qin Gregory J Duns Wei-Dong Zhang Jiang-Jiang Qin Xin Luan 
supported by the Science and Technology Innovation Program of Hunan Province(No.2022RC1168);National Natural Science Foundation of China(Nos.82322073,82173846,82304533);CAMS Innovation Fund for Medical Sciences(CIFMS)(No.2023-I2M-3-009);Key project at central government level:The ability establishment of sustainable use for valuable Chinese medicine resources(No.2060302);China Postdoctoral Science Foundation(No.2021M702215);Oriental Scholars of Shanghai Universities(No.TP2022081);Jiangxi Province Thousand Talents Program(No.jxsq2023102168);Young Talent Lifting Project of China Association of Chinese Medicine(No.CACM-(2021-QNRC2-A08));Shanghai Rising-Star Program(No.22QA1409100);Shanghai Sailing Program(No.22YF1445000);2021 Shanghai Science and Technology Innovation Action Plan(No.21S11902800);Three-year Action Plan for Shanghai TCM Development and Inheritance Program(Nos.ZY(2021-2023)-0208,ZY(2021-2023)-0401);High level Key Discipline of National Administration of Traditional Chinese Medicine(No.71);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202004);Innovation team of high-level local universities in Shanghai:Strategic Innovation Team of TCM Chemical Biology。
Despite ongoing advancements in cancer treatment,the emergence of primary and acquired resistance poses a significant challenge for both traditional chemotherapy and immune checkpoint blockade therapies.The demand for...
关键词：Drug resistance Antitumor peptides Mechanism of action Targeted therapeutics IMMUNOTHERAPY Medicinal chemistry 
Silicon-based metal-organic frameworks(SiMOFs)for immunogenic cell death in cancer therapy
《Nano Research》2025年第1期628-641,共14页Min Han Zishan Chen Shiying Zhou Zunde Liao Xiangting Yi Yao He Yiling Zhong Kam W.Leong 
support from the Basic and Applied Basic Research Foundation of Guangdong Province,China(No.2021A1515220001).
Silicon-based nanomaterials,known for their unique properties and favorable biocompatibility,significantly impact sectors like energy,electronics,and biomedicine.Recently,metalorganic frameworks(MOFs)have emerged as p...
关键词：silicon-based nanomaterials NANOCARRIERS immunogenic cell death antitumor immune responses 
Mito-specific cascade amplifier sniping metabolism homeostasis for multimodal imaging-guided antitumor bioenergetic therapy
《Nano Research》2024年第11期9908-9919,共12页Jingjing Yang Yuanlin Zhang Maoquan Chu Jin Qian Jie Liu Manyu Wang Zhe Qiang Jie Ren 
financially supported by the Shanghai 2020 “Science and Technology Innovation Action Plan” Social Development Science and Technology Research Project(No.20dz1203600);the Fundamental Research Funds for the Central Universities,and the Open Funds for Characterization of Tongji University.
Nicotinamide adenine dinucleotide (NAD+/NADH) pools homeostasis is recognized as an Achilles’ Heel in tumor metabolism reprogramming. However, mitochondria can enable cancer cells to overcome NADH exhaustion by provi...
关键词：metabolism programming nicotinamide adenine dinucleotide(NAD+/NADH)pools homeostasis disruption mitochondrial-targeting cascade therapy magnetic resonance imaging(MRI)/photoacoustic imaging(PAI) 
Application of magnetotactic bacteria as engineering microrobots:Higher delivery efficiency of antitumor medicine
《Chinese Chemical Letters》2024年第10期139-146,共8页Jing Zhang Charles Wang Yaoyao Zhang Haining Xia Yujuan Wang Kun Ma junfeng Wang 
supported by the National Natural Science Foundation of China(No.3190110313 to K.Ma);Special Foundation of President of the Chinese Academy of Sciences(No.YZJJ2022QN_(4)4);HFIPS Director’s Fund(Nos.E16CWK123X1;YZJJQY202201);the Heye Health Technology Chong Ming Project(No.HYCMP-2022012 to Y.Wang)。
For a significant duration,enhancing the efficacy of cancer therapy has remained a critical concern.Magnetotactic bacteria(MTB),often likened to micro-robots,hold substantial promise as a drug delivery system.MTB,clas...
关键词：Magnetotactic bacteria Engineering microrobot Tumor treatment Drug delivery BIOCONJUGATION 
Pharmacological effects of bioactive agents in earthworm extract:A comprehensive review
《Animal Models and Experimental Medicine》2024年第5期653-672,共20页Zihan Zhu Xinyi Deng Wenqing Xie Hengzhen Li Yusheng Li Zhenhan Deng 
supported by the National Key R&D Program of China(2021YFC2502100,2023YFC3603404,2019YFA0111900);National Natural Science Foundation of China(82072506,82272611,92268115);Hunan Provincial Science Fund for Distinguished Young Scholars(2024JJ2089);Hunan Young Talents of Science and Technology(2021RC3025);Provincial Clinical Medical Technology Innovation Project of Hunan(2023SK2024,2020SK53709);Provincial Natural Science Foundation of Hunan(2020JJ3060);National Natural Science Foundation of Hunan Province(2023JJ30949);National Clinical Research Center for Geriatric Disorders,Xiangya Hospital(2021KFJJ02,2021LNJJ05);the Hunan Provincial Innovation Foundation for Postgraduate(CX20230308,CX20230312);the Independent Exploration and Innovation Project for Postgraduate Students of Central South University(2024ZZTS0163)。
This review compiles information from the literature on the chemical composition,pharmacological effects,and molecular mechanisms of earthworm extract(EE)and suggests possibilities for clinical translation of EE.We al...
关键词：ANTITHROMBOTIC ANTITUMOR bioactive agent earthworm extract pharmacological effects 
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