Review of Astragalus membranaceus polysaccharides:Extraction process,structural features,bioactivities and applications  

作　　者：Hongyue Tian Lingzhuo An Pengwang Wang Xuemin Zhang Wenyuan Gao Xia Li 

机构地区：[1]Tianjin Key Laboratory for Modern Drug Delivery&High-Efficiency,School of Pharmaceutical Science and Technology,Tianjin University,Tianjin 300193,China [2]Key Laboratory of Modern Chinese Medicine Resources Research Enterprises,Tianjin 300402,China [3]College of Pharmacy,Qinghai Minzu University,Qinghai 810007,China

出　　处：《Chinese Herbal Medicines》2025年第1期56-69,共14页中草药(英文版)

基　　金：supported by Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202005);Key project at central government level(No.2060302);National Natural Science Foundation of China(No.81872956);Special Project for Transformation of Scientific and Technological Achievements in Qinghai Province(No.2021-SF-150)。

摘　　要：Astragalus membranaceus possesses the function of enhancing immunity,protecting the liver,diuretic,anti-aging,anti-stress,anti-hypertensive,and more extensive antibacterial effects.Polysaccharides,one kind of the major active ingredients of A.membranaceus,are considered to be responsible for their versatile use.Now,a systematic summary of research progress and prospects of polysaccharides from A.membranaceus polysaccharides(AMPs)is necessary to facilitate their further study and application.In this review,the optimal extraction methods,structural features,biological activities,and applications of AMPs were emphasized.The structure-activity relationships are also analyzed and elucidated.Solvent,ultrasonic,microwave,enzyme-assisted,ultra-high pressure,and combined methods have been used to extract AMPs.Among them,solvent extraction is the most commonly used method because it is simple and easy to operate,but the efficiency needs to be improved further.The ultra-high pressure method is the most efficient but has a low economic return.AMPs exhibited various bioactivities,including immunomodulation,antitumor,and antidiabete.The structure-activity relationships revealed that different structure configurations,chain conformations,and physical properties would have different bioactivities.However,the new method for purification of certain polysaccharides,detailed structure-activity relationships(SAR),mechanisms of bioactivities,and quality control of AMPs need to be extensively investigated.

关 键 词：antidiabetic activity ANTITUMOR APPLICATIONS Astragalus membranaceus(Fisch.)Bge. Astragalus membranaceus polysaccharides extraction process IMMUNOMODULATION structure-activity relationship 

分 类 号：R284[医药卫生—中药学] R285[医药卫生—中医学]