Application of magnetotactic bacteria as engineering microrobots:Higher delivery efficiency of antitumor medicine  

作　　者：Jing Zhang Charles Wang Yaoyao Zhang Haining Xia Yujuan Wang Kun Ma junfeng Wang 

机构地区：[1]High Magnetic Field Laboratory,CAS Key Laboratory of High Magnetic Field and lon Beam Physical Biology,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Hefei 230031,China [2]University of Science and Technology of China,Hefei 230026,China [3]University of California,San Diego,La Jolla,CA 92093,United States [4]International Magnetobiology Frontier Research Center,Hefei 230031,China

出　　处：《Chinese Chemical Letters》2024年第10期139-146,共8页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.3190110313 to K.Ma);Special Foundation of President of the Chinese Academy of Sciences(No.YZJJ2022QN_(4)4);HFIPS Director’s Fund(Nos.E16CWK123X1;YZJJQY202201);the Heye Health Technology Chong Ming Project(No.HYCMP-2022012 to Y.Wang)。

摘　　要：For a significant duration,enhancing the efficacy of cancer therapy has remained a critical concern.Magnetotactic bacteria(MTB),often likened to micro-robots,hold substantial promise as a drug delivery system.MTB,classified as anaerobic,aquatic,and gram-negative microorganisms,exhibit remarkable motility and precise control over their internal biomineralization processes.This unique ability results in the formation of magnetic nanoparticles arranged along filamentous structures in a catenary fashion,enclosed within a membrane.These bacteria possess distinctive biochemical properties that facilitate their precise positioning within complex environments.By harnessing these biochemical attributes,MTB could potentially offer substantial advantages in the realm of cancer therapy.This article reviews the drug delivery capabilities of MTB in tumor treatment and explores various applications based on their inherent properties.The objective is to provide a comprehensive understanding of MTB-driven drug delivery and stimulate innovative insights in this field.

关 键 词：Magnetotactic bacteria Engineering microrobot Tumor treatment Drug delivery BIOCONJUGATION 

分 类 号：R730.53[医药卫生—肿瘤]