BIOCONJUGATION

作品数：25被引量：39H指数：4
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Exploring Protein Bioconjugation:A Redox-Based Strategy for Tryptophan Targeting
《Research》2025年第1期578-580,共3页Qian-Qian Yang Shuai-Jiang Liu Wei Huang Cheng Peng Bo Han 
financial support from the National Natural Science Foundation of China(82374020 and 82374155);Science and Technology Department of Sichuan Province(2023ZYD0054 and 2024NSFTD0023);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202209).
Amino acid bioconjugation technology has emerged as a pivotal tool for linking small-molecule fragments with proteins,antibodies,and even cells.The study in Nature by Chang and Toste introduces a redox-based strategy ...
关键词：click reactionsmeanwhilethis small molecule fragments protein bioconjugation redox based strategy tryptophan targeting amino acid bioconjugation oxidative cyclization reagentsdemonstrating 
Application of magnetotactic bacteria as engineering microrobots:Higher delivery efficiency of antitumor medicine
《Chinese Chemical Letters》2024年第10期139-146,共8页Jing Zhang Charles Wang Yaoyao Zhang Haining Xia Yujuan Wang Kun Ma junfeng Wang 
supported by the National Natural Science Foundation of China(No.3190110313 to K.Ma);Special Foundation of President of the Chinese Academy of Sciences(No.YZJJ2022QN_(4)4);HFIPS Director’s Fund(Nos.E16CWK123X1;YZJJQY202201);the Heye Health Technology Chong Ming Project(No.HYCMP-2022012 to Y.Wang)。
For a significant duration,enhancing the efficacy of cancer therapy has remained a critical concern.Magnetotactic bacteria(MTB),often likened to micro-robots,hold substantial promise as a drug delivery system.MTB,clas...
关键词：Magnetotactic bacteria Engineering microrobot Tumor treatment Drug delivery BIOCONJUGATION 
Interfacing DNA and Aptamers with Gold Nanoparticles:From Fundamental Colloid and Interface Sciences to Biosensors
《Chinese Journal of Chemistry》2024年第19期2391-2400,共10页Yuzhe Ding Juewen Liu 
Comprehensive Summary Interfacing DNA oligonucleotides and DNA aptamers with gold nanoparticles has generated numerous functional hybrid materials for sensing,self-assembly and drug delivery applications.Our lab has b...
关键词：Aptamers Biosensors Gold nanoparticles SELEX BIOCONJUGATION 
Identification of Styryl Sulfonyl Fluoride as a Near-Perfect Michael Acceptor for Diversified Protein Bioconjugations
《CCS Chemistry》2023年第10期2251-2263,共13页Qingsong Wu Qi Xue Ji Li Qinheng Zheng Xinlu Zhao Wannan Li Shiming Sun Wanxing Sha Yang Yang Yi Yang Jie P.Li 
Financial support from the National Key R&D Program of China(grant no.2019YFA09006600);the National Natural Science Foundation of China(grant nos.21977048 and 92053111);the Natural Science Foundation of Jiangsu Province(grant no.BK20202004);the Beijing National Laboratory for Molecular Sciences(grant no.BNLMS20200);the Jiangsu Specially-Appointed Professor Plan,and the Program for Innovative Talents and Entrepreneur in Jiangsu is gratefully acknowledged.Q.Z.is the Connie and Bob Lurie Fellow of the Damon Runyon Cancer Research Foundation(DRG-2434-21).
Cysteine(Cys)-specific bioconjugation has widespread applications in the synthesis of protein conjugates,particularly for the functionalization of antibodies.Here,we report the discovery of transstyryl sulfonyl fluori...
关键词：styryl sulfonyl fluoride cysteine bioconjugation serum-stable ADC DNA-protein conjugates CITE-seq 
Click chemistry in the design of AIEgens for biosensing and bioimaging
《Aggregate》2023年第4期71-92,共22页Marie-Claire Giel Yuning Hong 
Australian Research Council,Grant/Award Number:FT210100271;Australia-China Science and Research Fund-Joint Research Centre on Personal Health Technologies,Grant/Award Number:ACSRF65777。
The development of rapid,selective,and sensitivefluorescent sensors is essential for visualizing and quantifying biological molecules and processes in vitro,ex vitro,and in vivo,which is important for not only fundame...
关键词：activity-based sensing aggregation induced emission bioconjugation chemistry click chemistry 
Novel ACE inhibitory peptides derived from bighead carp (Aristichthys nobilis) hydrolysates: Screening, inhibition mechanisms and the bioconjugation effect with graphene oxide被引量：1
《Food Bioscience》2023年第2期488-496,共9页Mengting Chen Lan Wang Changliang Zheng Aimin Ma Kai Hu Aoli Xiang Zhida Sun Bijun Xie Guangquan Xiong Liu Shi Sheng Chen Wenjin Wu 
The research was funded by the National Key R&D Program of China(2019YFD0901805).
The ACE inhibitory peptides have been characterized from the enzymatic digestion product of bighead carp protein and bioconjugated with graphene oxide(GO)to enhance its activity.The results showed that aspartic acid a...
关键词：ACE inhibitory activity Bioactive peptides Molecular docking Graphene oxide BIOCONJUGATION 
Optimization of the Process for Preparing Bivalent Polysaccharide Conjugates to Develop Multivalent Conjugate Vaccines against Streptococcus pneumoniae or Neisseria meningitidis and Comparison with the Corresponding Licensed Vaccines in Animal Models被引量：1
《Current Medical Science》2023年第1期22-34,共13页Fang HUANG Xiao-bing JING Yin-bo LI Qian WANG Si-li LIU Zhi-rong YANG Su FENG 
Objective:This study aimed to describe,optimize and evaluate a method for preparing multivalent conjugate vaccines by simultaneous conjugation of two different bacterial capsular polysaccharides(CPs)with tetanus toxoi...
关键词：multivalent conjugate vaccine pneumococcal conjugate vaccine meningococcal conjugate vaccine BIOCONJUGATION IMMUNOGENICITY 
A versatile AIE fluorogen with selective reactivity to primary amines for monitoring amination,protein labeling,and mitochondrial staining
《Aggregate》2023年第1期250-259,共10页Xinyuan He Huilin Xie Lianrui Hu Pengchao Liu Changhuo Xu Wei He Wutong Du Siwei Zhang Hao Xing Xinyue Liu Hojeong Park Tsz Shing Cheung Min-Hui Li Ryan T.K.Kwok Jacky W.Y.Lam Jian Lu Ben Zhong Tang 
National Natural Science Foundation of China,Grant/Award Number:21788102;Research Grants Council of Hong Kong,Grant/Award Numbers:16307020,16306620,16305518,N_HKUST609/19,C6009-17G,C6014-20w;Innovation and Technology Commission,Grant/Award Numbers:ITC-CNERC14SC01,ITCPD/17-9;Natural Science Foundation of Guangdong Province,Grant/Award Number:201913121205002。
Specific bioconjugation for native primary amines is highly valuable for both chemistry and biomedical research.Despite all the efforts,scientists lack a proper strategy to achieve high selectivity for primary amines,...
关键词：aggregation-induced emission(AIE) BIOCONJUGATION mitochondria-staining primary amines protein labeling 
Cysteine-Specific Bioconjugation and Stapling of Unprotected Peptides by Chlorooximes
《CCS Chemistry》2022年第10期3355-3363,共9页Qingqing Chen Tengfang Long Jie Zheng Wangjian Sheng Shuaishuai Sun Wei Wei Jing Zhao Huan Wang 
supported by the National Natural Science Foundation(NSF)of China(grant nos.21922703 and 91953112);the NSF of Jiangsu Province(grant nos.BK20190004 and BK20202004);the National Key R&D Program of China(grant no.2019YFA0905800);Shenzhen Basic Research Program(grant no.JCYJ20180508-182240106);the Fundamental Research Funds for the Central Universities(grant nos.14380138 and 14380131).
Cyclic peptides have found applications in fields ranging from drug discovery to nanomaterials.Peptide stapling reagents crosslink two or more residues in peptides to generate macrocycles of diverse topology and intro...
关键词：cyclic peptides peptide stapling BIOCONJUGATION chlorooximes CYSTEINE 
Biomimetic Recognition-Based Bioorthogonal Host-Guest Pairs for Cell Targeting and Tissue Imaging in Living Animals
《CCS Chemistry》2022年第6期1977-1989,共13页Yan-Long Ma Chen Sun Zeshun Li Ziyi Wang Jianwen Wei Qian Cheng Li-Shuo Zheng Xiao-Yong Chang Kai Li Ruibing Wang Wei Jiang 
financially supported by National Natural Science Foundation of China(nos.21772083 and 21822104);the Shenzhen Special Funds(no.JCYJ20180504165810828);the Guangdong Provincial Key Laboratory of Catalysis(no.2020B121201002);the University of Macao(no.MYRG2019-00059-ICMS);the Shenzhen“Pengcheng Scholar”Program;Guangdong High-Level Personnel of Special Support Program(no.2019TX05C157);SUSTech-CRF for the technical support.
Bioconjugation methods offer very important tools in studying biological systems.Synthetic host-guest pairs provide an alternative and complementary conjugation method to bioorthogonal reactions and biological associa...
关键词：cell targeting tissue imaging BIOCONJUGATION bioorthogonal host-guest pair naphthotube 
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