Interfacing DNA and Aptamers with Gold Nanoparticles:From Fundamental Colloid and Interface Sciences to Biosensors  

作　　者：Yuzhe Ding Juewen Liu 

机构地区：[1]Department of Chemistry,Waterloo Institute for Nanotechnology,University of Waterloo,Waterloo,Ontario,N2L 3G1,Canada

出　　处：《Chinese Journal of Chemistry》2024年第19期2391-2400,共10页中国化学（英文版）

摘　　要：Comprehensive Summary Interfacing DNA oligonucleotides and DNA aptamers with gold nanoparticles has generated numerous functional hybrid materials for sensing,self-assembly and drug delivery applications.Our lab has been working in this area for 15 years.In this article,the current understanding of the adsorption of DNA to gold nanoparticles is summarized,and related applications in bioconjugation of DNA to gold surface is described.In addition,problems of using gold nanoparticles to signaling aptamer binding are discussed.Finally,re-selection of aptamers for previously reported targets using the library-immobilization method is reviewed.

关 键 词：Aptamers Biosensors Gold nanoparticles SELEX BIOCONJUGATION 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置] TB383[自动化与计算机技术—控制科学与工程]