financially supported by the National Natural Science Foundation of China(31730069);Graduate Innovation Fund of Dalian Polytechnic University。
Aging is a physiological process that leads to degeneration and functional decline of the brain.This is accompanied by intracellular peroxidation and neuronal apoptosis.Natural antioxidants possess a remarkable effect...
This work was supported by the National Key R&D Program of China(No.2022YFA1205801);National Natural Science Foundation of China(Nos.T2225026,82172087,82071308,and 82404099);Peking University Third Hospital Clinical Key Project(Nos.BYSYZD2023041 and BYSYRCYJ2023004);Beijing Institute of Technology Research Fund Program for Young Scholars,and Outstanding Young Talent Project of Capital Medical University.
It is well reported that cellular ferritin reduces the intracellular oxidative stress by sequestering excess ferrous ions,preventing them from participating in Fenton reactions that generate damaging harmful reactive ...
supported by the National Natural Science Foundation of China(81502688);Cooperation Research Funding of Capital Medical University(2020KJ000514,China);Cooperation Research Funding of Capital Medical University(2023KJ000814,China);R&D Program of Beijing Municipal Education Commission(KM202210025024,China).
Ferroptosis has received great attention as an iron-dependent programmed cell death for efficient cancer therapy.However,with the accumulation of iron in tumor cells,the antioxidant system is activated by reducing glu...
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0490000).
Nipah virus(NiV)is a zoonotic paramyxovirus in the genus Henipavirus that is prevalent in Southeast Asia.NiV leads to severe respiratory disease and encephalitis in humans and animals,with a mortality rate of up to 75...
supported by the National Natural Science Foundation of China(31730069 and 31771926).
Ferritin has good thermal stability,resistance to certain acids and bases,and targeting,and has broad application prospects in the synthesis of gold nanostars(AuNS).In this study,we screened monodisperse AuNS with uni...
BACKGROUND Gastric cancer is a kind of malignant tumor which is prevalent all over the world.Although some progress has been made in the treatment of gastric cancer,its prognosis is still not optimistic,so it is of gr...
The existing literature on neurodegenerative diseases(NDDs)reveals a common pathological feature:the accumulation of misfolded proteins.However,the heterogeneity in disease onset mechanisms and the specific brain regi...
Iron is a double-edged sword!Despite being essential for numerous physiological processes of the body,a dysregulated iron metabolism can result in tissue da-mage,exaggerated inflammatory response,and increased suscept...
Inflammatory bowel disease(IBD)is a relapsing chronic inflammatory disorder of the small and large gut with rising incidence and prevalence worldwide.Iron deficiency anemia is one of the most common extraintestinal ma...
Supported by the Oregon Health&Sciences(OHSU)Institutional Review Board,No.STUDY00026428.
BACKGROUND The incidence of early-onset colorectal cancer(EO-CRC)is rising in the United States,and is often diagnosed at advanced stages.Low serum ferritin is often incidentally discovered in young adults,however,the...