Ferritin nanocage loading lycopene for improving blood-brain barrier transcytosis and attenuating D-galactose-induced apoptosis in PC12 cells  

作　　者：Xiaoyu Xia Han Li Xianbing Xu Zhenyu Wang Junjie Yi Guanghua Zhao Ming Du 

机构地区：[1]School of Food Science and Technology,Dalian Polytechnic University,Dalian 116034,China [2]Collaborative Innovation Centre of Provincial and Ministerial Co-construction for Seafood Deep Processing,Dalian 116034,China [3]National Engineering Research Centre of Seafood,Dalian 116034,China [4]Faculty of Food Science and Engineering,Kunming University of Science and Technology,Kunming 650500,China [5]College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China

出　　处：《Food Science and Human Wellness》2025年第3期880-891,共12页食品科学与人类健康(英文)

基　　金：financially supported by the National Natural Science Foundation of China(31730069);Graduate Innovation Fund of Dalian Polytechnic University。

摘　　要：Aging is a physiological process that leads to degeneration and functional decline of the brain.This is accompanied by intracellular peroxidation and neuronal apoptosis.Natural antioxidants possess a remarkable effect on attenuating the oxidative stress cascade and apoptosis of neurons;however,the challenge of using natural antioxidants for neuroprotection is fabricating a delivery system to overcome the blood-brain barrier(BBB)transport.Herein,we successfully created a stable delivery platform built on rigid ferritin nanocage loading natural lycopene molecules,crossing the BBB in quantity and being taken up in neurons.This nanoparticle worked on D-galactose-induced senescence via alleviating neuronal hyperoxidation injury and weakening neuronal apoptosis in PC12 and BV2 cells.More importantly,this natural delivery system possesses inherent biocompatibility and potential application in improving the bioavailability of bioactive edible compounds with low water solubility.This study demonstrated the effectiveness of natural antioxidant nanomedicines in maintaining the defenses of intracerebral peroxidation and improve degenerating neurons,providing the potential to combat further imbalances of neuronal microenvironment in aging neuropathy.

关 键 词：FERRITIN LYCOPENE NANOCARRIER Neuroprotection Aging 

分 类 号：R74[医药卫生—神经病学与精神病学]