HYDROLASE

作品数：82被引量：161H指数：7
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相关作者：朱毅霍雷军丁文双田东萍王魁更多>>
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Bifunctional ZrO_(2)@ZIF-90 nanozyme with high phosphohydrolase activity for sensitive electrochemical detection of methyl parathion
《Food Science and Human Wellness》2025年第2期749-757,共9页Xiaomin Pang Geoffrey I.N.Waterhouse Ruiqiang Wang Xuguang Qiao Yufeng Sun Zhixiang Xu 
financially supported by the National Natural Science Foundation of China(No.31972149);Innovation Capability Improvement Project of Scientific and Technological Small and Medium-sized Enterprises in Shandong Province(No.2022TSGC2409);the Mac Diarmid Institute for Advanced Materials and Nanotechnology and the Dodd-Walls Centre for Photonic and Quantum Technologies。
In this work,a novel bifunctional zirconium dioxide@zeolitic imidazolate framework-90(ZrO_(2)@ZIF-90)nanozyme was successfully developed for the catalytic degradation and electrochemical detection of methyl parathion(...
关键词：Methyl parathion Organophosphorus pesticides Nanozyme ZrO_(2)@ZIF-90 Electrochemical detection 
α/βhydrolase domain-containing protein 1 acts as a lysolipid lipase and is involved in lipid droplet formation
《National Science Review》2024年第12期144-154,共11页Ismael Torres-Romero Bertrand Légeret Marie Bertrand Damien Sorigue Alicia Damm Stéphan Cuiné Florian Veillet Carla Blot Sabine Brugière Yohann Couté Matthew G.Garneau Hari K.Kotapati Yi Xin Jian Xu Philip D.Bates Abdou R.Thiam Fred Beisson Yonghua Li-Beisson 
supported by the European Union Regional Developing Fund(ERDF),the Région Provence Alpes Côte d’Azur,the French Ministry of Research and the French Alternative Energies and Atomic Energy Commission(CEA)by way of funding the HelioBiotec platform;supported by Fundamental Research Division(DRF)Impulsion LD power;I.T.R.is the recipient of an international PhD studentship from CEA(program Irtelis).A.R.T.is supported by ANR-21-CE11-0032-02-LIPRODYN.M.G.G.,H.K.K;P.D.B.are supported by the National Science Foundation(PGRP-IOS-1829365);The proteomic experiments were par tially suppor ted by Agence Nationale de la Recherche under projects ProFI(Proteomics French Infrastructure,ANR-10-INBS-08);GRAL(Grenoble Alliance for Integrated Structural&Cell Biology),a program from the Chemistry Biology Health(CBH)Graduate School of University Grenoble Alpes(ANR-17-EURE-0003).
Lipid droplets(LDs)are the major sites of lipid and energy homeostasis.However,few LD biogenesis proteins have been identified.Using model microalga Chlamydomonas,we show that ABHD1,anα/β-hydrolase domain-containing...
关键词：ALGAE betaine lipid α/βhydrolase lipid droplet lysolipid 
Machine learning meets enzyme engineering: examples in the design of polyethylene terephthalate hydrolases
《Frontiers of Chemical Science and Engineering》2024年第12期105-116,共12页Rohan Ali Yifei Zhang 
This work was supported by the National Natural Science Foundation of China under grant number 32371325;the Seed Funding of China Petrochemical Corporation(Sinopec Group)under grant number 223260;the Fundamental Research Funds for the Central Universities(QNTD2023-01).
The trend of employing machine learning methods has been increasing to develop promising biocatalysts.Leveraging the experimental findings and simulation data,these methods facilitate enzyme engineering and even the d...
关键词：machine learning artificial intelligence enzyme engineering polyethylene terephthalate hydrolase enzyme design 
Biomimetic Phosphohydrolase Nanozyme Based on Defect-Engineered Metal-Organic Framework
《CCS Chemistry》2024年第7期1821-1835,共15页Xiaoxue Kou Yuhong Lin Yong Shen Linjing Tong Rui Gao Suya Liu Siming Huang Fang Zhu Guosheng Chen Gangfeng Ouyang 
financially supported by the projects of the National Natural Science Foundation of China (grant nos.22174164,G.C.,22104159,S.H.);the Natural Science Foundation of Guangzhou City (grant no.202201011408,G.C.);the Fundamental Research Funds for the Central Universities,and Sun Yat-sen University (grant no.23lgbj005,G.C.).
Phosphodiester bonds are the backbone linkages of all the nucleic acids which store and transfer biological information.The hydrolysis of phosphodiester bonds is of great importance to the replication,recombination,an...
关键词：nanozyme metal-organic framework biomimetic catalysis hydrolase-like activity defective engineering 
SsdchA is a novel secretory cellobiohydrolase driving pathogenicity in Sclerotinia sclerotiorum
《The Crop Journal》2024年第2期493-502,共10页Yangui Chen Yijuan Ding Siqi Zhao Nan Yang Zhaohui Wu Ping Zhang Hongmei Liao Mengquan Dong Yang Yu Huafang Wan Wei Qian 
financially supported by the National Nature Science Foundation of China (32372077);the Project of Chongqing Science and Technology Commission (CSTB2023NSCQ-MSX0355);the Fundamental Research Funds for the Central Universities (SWU120075)。
The necrotrophic fungus, Sclerotinia sclerotiorum, employs an array of cell wall-degrading enzymes(CWDEs), including cellulase, to dismantle host cell walls. However, the molecular mechanisms through which S. scleroti...
关键词：CELLOBIOHYDROLASE CELLULOSE PATHOGENICITY Sclerotinia sclerotiorum Secretory protein SsdchA 
Exploring the bioactive compounds of Feiduqing formula for the prevention and management of COVID-19 through network pharmacology and molecular docking
《Medical Data Mining》2024年第1期16-23,共8页Shuang-Lin Qin Hui Yao Ting Huang Hong-Fei Yang Ting-Ting Ge Jie-Qiong Wang Wei-Wu Wang Qing Min 
Key Projects in Xianning science and technology project (No.2020SFYF01);Youth Talent Project of Health Commission of Hubei Province (No.ZY2021Q026).
Background:To explore the effective chemical constituents of Feiduqing formula for prevention and treatment of coronavirus disease 2019(COVID-19).Methods:The compounds and action targets of twelve herbal medicines in ...
关键词：Feiduqing formula COVID-19 network pharmacology molecular docking SARS-CoV-23CL hydrolase 
a-Synuclein: A fusion chaperone significantly boosting the enzymaticperformance of PET hydrolase
《Chinese Journal of Chemical Engineering》2023年第12期18-25,共8页Renwen Tian Yan Sun 
the National Key Research and Development Program of China(2018YFA0900702).
Extensive use of polyethylene terephthalate (PET) has brought about global environmental problems. Arecently reported PET hydrolase (PETase) discovered from Ideonella sakaiensis showed high potentialfor degrading PET ...
关键词：PET hydrolase a-Synuclein Fusion enzyme Stability Pollution Degradation 
Biosynthesis of trialkyl-substituted aromatic polyketide NFAT-133 involves unusual P450 monooxygenase-mediating aromatization and a putative metallo-beta-lactamase fold hydrolase
《Synthetic and Systems Biotechnology》2023年第3期349-356,共8页Ming Yang Wanlu Li Lin Zhou Xiao Lin Wenyu Zhang Yaoyao Shen Hai Deng Hou-wen Lin Yongjun Zhou 
the National Natural Science Foundation of China(Nos.32070070,32211530074 and 31929001);the innovative research team of high-level local universities in Shanghai.H.D.thanks Royal Society-NSFC international exchange grant(IEC\NSFC\211349).
The bacterial trialkyl-substituted aromatic polyketides are structurally featured with the unusual aromatic core in the middle of polyketide chain such as TM-123(1),veramycin A(2),NFAT-133(3)and benwamycin I(4),which ...
关键词：Thioesterase Metallo hydrolase METALLO-BETA-LACTAMASE Aromatic polyketide Polyketide synthase P450 monooxygenase 
Changes and significance of serum ubiquitin carboxyl-terminal hydrolase L1 and glial fibrillary acidic protein in patients with glioma
《World Journal of Clinical Cases》2023年第14期3158-3166,共9页Qing-Hua Zhu Jing-Kun Wu Gao-Lei Hou 
Supported by Hebei Medical Science Research Project,No.20220648。
BACKGROUND Brain gliomas are malignant tumors with high postoperative recurrence rates.Early prediction of prognosis using specific indicators is of great significance.AIM To assess changes in ubiquitin carboxy-termin...
关键词：GLIOMA Ubiquitin carboxy-terminal hydrolase L1 Glial fibrillary acidic protein Surgery Prognosis Clinical significance 
Anα/βhydrolase family member negatively regulates salt tolerance but promotes flowering through three distinct functions in rice被引量：5
《Molecular Plant》2022年第12期1908-1930,共23页You-Huang Xiang Jia-Jun Yu Ben Liao Jun-Xiang Shan Wang-Wei Ye Nai-Qian Dong Tao Guo Yi Kan Hai Zhang Yi-Bing Yang Ya-Chao Li Huai-Yu Zhao Hong-Xiao Yu Zi-Qi Lu Hong-Xuan Lin 
This work was supported by thegrants from Laboratory of Lingnan Modern Agriculture Project(NT2021002);National Natural Science Foundation of China(31788103);Chinese Academyof Sciences(XDB27010104,QYZDY-SSW-SMC023,159231KYSB20200008);CAS-Croucher Funding Scheme for Joint Laboratories,and National Key Laboratory of Plant MolecularGenetics。
Ongoing soil salinization drastically threatens crop growth,development,and yield worldwide.It is therefore crucial that we improve salt tolerance in rice by exploiting natural genetic variation.However,many salt-resp...
关键词：RICE salt tolerance flowering time grain yield fatty acid 
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