supported by the National Natural Science Foundation of China(Nos.12204358 and 62204214);the Young Top-notch Talent Cultivation Program of Hubei Province(X.-T.Z.);the Fundamental Research Funds for the Central Universities(No.2042023kf0091);the Youth Interdisciplinary Special Fund of Zhongnan Hospital of Wuhan University(No.ZNQNJC2022005).
Androgen deprivation therapy(ADT)and androgen receptor signaling inhibitors(ARSis)often have limited efficacy in patients with advanced prostate cancer(PCa)(especially AR-negative).Inducing ferroptosis in PCa cells is...
supported by the Deanship of Scientific Research,Vice Presidency for Graduate Studies and Scientific Research,King Faisal University,Saudi Arabia,grant number KFU242733.
The medicinal herb Geranium wallichianum belongs to the family Geraniaceae. The East Asian Himalayas are its primary habitat. Overexploitation and overharvesting pose a threat to this plant, given its extensive ethnom...
Ferroptosis, an iron-dependent type of cell death, is being considered for new clinical treatments of malignant tumors that are difficult to treat with apoptosis inducers. Although several reports have attempted to in...
The authors regret that there was an error in the use of GAPDH image in PANC-1 cells of Fig.5B due to mistakenly pasting in the process of assembling figures.The wrong data are replaced by right ones of the same batch...
supported by the National Natural Science Foundation of China(52061135103,51873236,52203287);Fundamental Research Funds for the Central Universities,Sun Yat-sen University(No.23yxqntd002).
Chiral covalent organic frameworks(COFs)have shown promising applications in asymmetric catalysis,enantiomer separation and chiral recognition due to their tunable structures and permanent porosity.Currently,synthesis...
This work was supported by the National Natural Science Foundation of China(Nos.82073714 and 32271539);the National Key Research and Development Program of China(No.2023YFF1104001);Fundamental Research Funds for the Central Universities,South-Central Minzu University(No.CZY23025).
The first total synthesis of talaroconvolutin A(1.1 g obtained)and talarofuranone has been achieved using accessible materials(12 steps,7.5%and 8.2%yields,respectively).Convergent routes involved intramolecular Diels-...
supported by the National Natural Science Foundation of China(Nos.52173137 and 51873163).
AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emissi...
supported by the Postdoctoral Scientific Research Developmental Fund of Heilongjiang(No.LBH-Q21130);the Beijing Medical Award Foundation(No.YXJL-2020-1207-0811).
Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen species.Fer...
This work was sup-ported in part by grants from the following sources:the National Natural Science Foundation of China(82203233,82202966,82173142,82302987,82303534,and 81972636);the Natural Science Foundation of Hunan Province(2023JJ60469,2023JJ40413,2023JJ30372,2023JJ30375,2022JJ80078,and 2020JJ5336);the Research Project of Health Commission of Hunan Province(202203034978,202109031837,and 20201020);Key Research and Devel-opment Program of Hunan Province(2022SK2051);Hunan Provincial Science and Technology Department(2020TP1018);the Changsha Science and Technology Board(kh2201054);the Changsha Municipal Natural Science Foundation(kq2014209);Ascend Foundation of National Cancer Center(NCC201909B06);Hunan Cancer Hospital Climb Plan(ZX2020001-3 and YF2020002);the Science and Technology Innovation Program of Hunan Province(2023RC3199,2023SK4034 and 2023RC1073);by China Postdoctoral Science Foundation(2022TQ0104 and 2022M721118).
Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to s...
supported by the National Key Research and Development Program(2022YFD1402100,2022YFD1401500);major Basic Research Project of Natural Science Foundation of Shandong Province(ZR2022ZD23);the National Natural Science Foundation(32072500,32272557);Shandong Modern Agricultural Industry Technology System(SDAIT-04-08);Shandong Province Key Research and Development Plan(2022TZXD0025,2021TZXD007-04-4);Taishan Scholar Program of Shandong Province.
Gray mold is a destructive disease caused by Botrytis cinerea,a pervasive plant pathogen,which poses a threat to both tomato growth and postharvest storage.The utilization of induced resistance presents a potential st...