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作品数：115被引量：432H指数：11
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相关领域：医药卫生生物学更多>>
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相关机构：中国人民解放军第一军医大学七台河市种子管理处黑龙江八一农垦大学中国医科大学附属第一医院更多>>
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Ferroptosis Inducer RSL3 Inhibits Cell Death by Camptothecin-Induced Apoptosis
《Journal of Biophysical Chemistry》2025年第1期1-13,共13页Koichi Sakurai Aira Koguma Nanako Akita Takeru Miyamoto Aya Fukura Sanae Muraoka Hirayama 
Ferroptosis, an iron-dependent type of cell death, is being considered for new clinical treatments of malignant tumors that are difficult to treat with apoptosis inducers. Although several reports have attempted to in...
关键词：Apoptosis Cell Viability DNA Laddering Ferroptosis Iron PEROXIDE 
Synthesis of Three-Dimensional Chiral Covalent Organic Frameworks Using Surfactant as Inducer in Water
《Chinese Journal of Chemistry》2024年第23期3093-3098,共6页Meiying Huang Zhipeng Zhou Xin Dong Yuyao Li Yonghang Yang Changye Zhan Jiaxing Lu Xiaoshu Wei Yuexian Hong Weiqi Cheng Wei Liu Zhongke Yuan Xudong Chen Zhikun Zheng 
supported by the National Natural Science Foundation of China(52061135103,51873236,52203287);Fundamental Research Funds for the Central Universities,Sun Yat-sen University(No.23yxqntd002).
Chiral covalent organic frameworks(COFs)have shown promising applications in asymmetric catalysis,enantiomer separation and chiral recognition due to their tunable structures and permanent porosity.Currently,synthesis...
关键词：Covalent organic frameworks CHIRALITY SURFACTANTS Amino acid derivatives Aqueous-phase synthesis Noncovalent interactions 
Total Synthesis and Stereochemical Assignment of Talaroconvolutin A and Talarofuranone: Gram-scale Synthesis of Ferroptosis Inducer Talaroconvolutin A
《Chinese Journal of Chemistry》2024年第13期1509-1514,共6页Ming Yao Wei Yang Jing Li Chengyun Huang Jin Fang Sulu Qin Shuzhi Liu Xiaolong Yang 
This work was supported by the National Natural Science Foundation of China(Nos.82073714 and 32271539);the National Key Research and Development Program of China(No.2023YFF1104001);Fundamental Research Funds for the Central Universities,South-Central Minzu University(No.CZY23025).
The first total synthesis of talaroconvolutin A(1.1 g obtained)and talarofuranone has been achieved using accessible materials(12 steps,7.5%and 8.2%yields,respectively).Convergent routes involved intramolecular Diels-...
关键词：Natural products ALDEHYDES Total synthesis Domino reactions Biological activity Antitumor agents Ferroptosis Diels-Alder reaction Talaroconvolutin A 
Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death
《Chinese Chemical Letters》2024年第5期338-343,共6页Kun-Heng Li Hong-Yang Zhao Dan-Dan Wang Ming-Hui Qi Zi-Jian Xu Jia-Mi Li Zhi-Li Zhang Shi-Wen Huang 
supported by the National Natural Science Foundation of China(Nos.52173137 and 51873163).
AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emissi...
关键词：Aggregation induced emission Photodynamic therapy Immunogenic cell death Reactive oxygen species Nanophotosensitizer MITOCHONDRIA 
Current and Potential Roles of Ferroptosis in Bladder Cancer
《Current Medical Science》2024年第1期51-63,共13页Wen-xin AN Radheshyam Gupta Kun ZHAI Ya-ru WANG Wan-hai XU Yan CUI 
supported by the Postdoctoral Scientific Research Developmental Fund of Heilongjiang(No.LBH-Q21130);the Beijing Medical Award Foundation(No.YXJL-2020-1207-0811).
Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen species.Fer...
关键词：ferroptosis bladder cancer ferroptosis-associated tumor signaling pathway ferroptosis inducer 
Cellular metabolism: A key player in cancer ferroptosis被引量：2
《Cancer Communications》2024年第2期185-204,共20页Xianjie Jiang Qiu Peng Mingjing Peng Linda Oyang Honghan Wang Qiang Liu Xuemeng Xu Nayiyuan Wu Shiming Tan Wenjuan Yang Yaqian Han Jinguan Lin Longzheng Xia Yanyan Tang Xia Luo Jie Dai Yujuan Zhou Qianjin Liao 
This work was sup-ported in part by grants from the following sources:the National Natural Science Foundation of China(82203233,82202966,82173142,82302987,82303534,and 81972636);the Natural Science Foundation of Hunan Province(2023JJ60469,2023JJ40413,2023JJ30372,2023JJ30375,2022JJ80078,and 2020JJ5336);the Research Project of Health Commission of Hunan Province(202203034978,202109031837,and 20201020);Key Research and Devel-opment Program of Hunan Province(2022SK2051);Hunan Provincial Science and Technology Department(2020TP1018);the Changsha Science and Technology Board(kh2201054);the Changsha Municipal Natural Science Foundation(kq2014209);Ascend Foundation of National Cancer Center(NCC201909B06);Hunan Cancer Hospital Climb Plan(ZX2020001-3 and YF2020002);the Science and Technology Innovation Program of Hunan Province(2023RC3199,2023SK4034 and 2023RC1073);by China Postdoctoral Science Foundation(2022TQ0104 and 2022M721118).
Cellular metabolism is the fundamental process by which cells maintain growth and self-renewal.It produces energy,furnishes raw materials,and intermedi-ates for biomolecule synthesis,and modulates enzyme activity to s...
关键词：cancer therapy cellular metabolism ferroptosis inducer ferroptosis 
Plant immune inducer ZNC promotes rutin accumulation and enhances resistance to Botrytis cinerea in tomato
《Stress Biology》2023年第1期387-402,共16页Haipeng Zhao Xiangyu Ding Xiaomeng Chu Haimiao Zhang Xinyu Wang Xinwen Zhang Haoqi Liu Xiaoying Zhang Ziyi Yin Yang Li Xinhua Ding 
supported by the National Key Research and Development Program(2022YFD1402100,2022YFD1401500);major Basic Research Project of Natural Science Foundation of Shandong Province(ZR2022ZD23);the National Natural Science Foundation(32072500,32272557);Shandong Modern Agricultural Industry Technology System(SDAIT-04-08);Shandong Province Key Research and Development Plan(2022TZXD0025,2021TZXD007-04-4);Taishan Scholar Program of Shandong Province.
Gray mold is a destructive disease caused by Botrytis cinerea,a pervasive plant pathogen,which poses a threat to both tomato growth and postharvest storage.The utilization of induced resistance presents a potential st...
关键词：Endophytic fungus extract METABOLOME FLAVONOIDS Tomato gray mold JA Signaling ROS 
Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β
《Signal Transduction and Targeted Therapy》2023年第12期5931-5943,共13页Hange Yang Xiaowei Zhang Cong Wang Hailong Zhang Juan Yi Kun Wang Yanzhe Hou Peihong Ji Xiaojie Jin Chenghao Li Min Zhang Shan Huang Haoyuan Jia Kuan Hu Lingyun Mou Rui Wang 
supported by the Program for the Ministry of Education“Peptide Drugs”Innovation Team(No.IRT_15R27,China);the National Natural Science Foundation of China(21807053);the CAMS Innovation Fund for Medical Sciences(CIFMS,Nos.2019-I2M-5-074,2021-I2M-1-026,2021-I2M-3-001,2022-I2M-2-002,China);the Fundamental Research Funds for the Central Universities(No.lzujbky-2023-11,lzujbky-2023-ct02,lzujbky-2023-it19,China).
The identification of effective drug targets and the development of bioactive molecules are areas of high need in cancer therapy.The phosphatidylinositol transfer protein alpha/beta isoform(PITPα/β)has been reported...
关键词：TUMOUR METABOLISM NUDE 
Structure-guided engineering of transcriptional activator XYR1 for inducer-free production of lignocellulolytic enzymes in Trichoderma reesei被引量：2
《Synthetic and Systems Biotechnology》2023年第4期732-740,共9页Qinqin Zhao Zezheng Yang Ziyang Xiao Zheng Zhang Jing Xing Huiqi Liang Liwei Gao Jian Zhao Yinbo Qu Guodong Liu 
supported by the National Key R&D Program of China(2018YFA0900500);National Natural Science Foundation of China(No.32170037);the Key research program of China National Tobacco Corporation(No.110202102018)。
The filamentous fungus Trichoderma reesei is widely used for the production of lignocellulolytic enzymes in industry.XYR1 is the major transcriptional activator of cellulases and hemicellulases in T.reesei.However,rat...
关键词：Xylanase Cellulase Trichoderma reesei Transcription factor Genome editing 
Experimental study on effects of air injection on cavitation pressure pulsation and vibration in a centrifugal pump with inducer
《Journal of Hydrodynamics》2023年第6期1168-1178,共11页Yan-hong Mao Hou-lin Liu Yong Wang Jie Chen Fei Liu 
supported by the National Natural Science Foundation of China(Grant No.51979126).
Cavitation commonly induces performance deterioration and system vibration in many engineering applications.This paper aims to investigate the effects of air injection on cavitation evolution,pressure pulsation and vi...
关键词：Air injection cavitation control INDUCER VIBRATION pressure pulsation 
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