Mild photothermal therapy-enhanced nano-ferroptosis inducer for potent treatment of advanced prostate cancer  

作　　者：Xiao Hu Fei Li Xin-Hang Qian Yu-Sen Zhang Shuai Ke Yun-Xia Jin Shuai Yuan Yuan-Yuan Zhang Rui Li Lei Cao Lang Rao Xian-Tao Zeng Ling-Ling Zhang 

机构地区：[1]Center for Evidence-Based and Translational Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,China [2]Institute of Chemical Biology,Shenzhen Bay Laboratory,Shenzhen 518132,China [3]Department of Urology,Zhongnan Hospital of Wuhan University,Wuhan 430071,China [4]Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials,Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules&College of Chemistry and Chemical Engineering,Hubei University,Wuhan 430062,China [5]Xinjiang Key Laboratory of Solid State Physics and Devices,School of Physics Science and Technology,Xinjiang University,Urumqi 830017,China

出　　处：《Nano Research》2025年第4期375-387,共13页纳米研究(英文版)

基　　金：supported by the National Natural Science Foundation of China(Nos.12204358 and 62204214);the Young Top-notch Talent Cultivation Program of Hubei Province(X.-T.Z.);the Fundamental Research Funds for the Central Universities(No.2042023kf0091);the Youth Interdisciplinary Special Fund of Zhongnan Hospital of Wuhan University(No.ZNQNJC2022005).

摘　　要：Androgen deprivation therapy(ADT)and androgen receptor signaling inhibitors(ARSis)often have limited efficacy in patients with advanced prostate cancer(PCa)(especially AR-negative).Inducing ferroptosis in PCa cells is an attractive therapeutic approach.In this work,mesoporous polydopamine nanoparticles(MPDA NPs)were developed to simultaneously deliver Cu^(+)/Cu^(2+)ion pairs and glutathione peroxidase 4(GPX4)inhibitor RSL3 to tumor sites for enhanced treatment of PCa.The prepared MPDA-Cu-RSL3@HA(MPCRH)NPs induced ferroptosis by promoting lipid peroxidation and regulating phospholipid profiles in PCa cells,and the above effects were further enhanced by mild photothermal therapy(mPTT)without damaging normal tissues.mPTT can promote reactive oxygen species(ROS)generation and degrade tumor extracellular matrix in vivo to promote nanodrugs intratumoral penetration.In short,this work shows the great application potential of mPTT-enhanced nano-ferroptosis inducers in the field of PCa treatment,in order to provide a reasonable paradigm for nanodrug development and PCa treatment.

关 键 词：prostate cancer ferroptosis mild photothermal therapy chemodynamic therapy mesoporous polydopamine 

分 类 号：R737.25[医药卫生—肿瘤]