Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death  

作　　者：Kun-Heng Li Hong-Yang Zhao Dan-Dan Wang Ming-Hui Qi Zi-Jian Xu Jia-Mi Li Zhi-Li Zhang Shi-Wen Huang 

机构地区：[1]Key Laboratory of Biomedical Polymers of Ministry of Education,Department of Chemistry,Wuhan University,Wuhan 430072,China

出　　处：《Chinese Chemical Letters》2024年第5期338-343,共6页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.52173137 and 51873163).

摘　　要：AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emission(AIE)molecules have been developed and have evoked massive ICD in cells.However,due to the complex physicochemical environment in cells,these small AIE molecules cannot maintain a stable aggregate state,which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photosensitizer to elicit ICD.AIEgen-based nanomicelles,which maintain a stable micellar structure,can prevent defects of AIE molecules in photodynamic therapy(PDT)applications.Therefore,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention.

关 键 词：Aggregation induced emission Photodynamic therapy Immunogenic cell death Reactive oxygen species Nanophotosensitizer MITOCHONDRIA 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R392[医药卫生—免疫学]