ARTESUNATE

作品数：73被引量：225H指数：8
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相关领域：医药卫生更多>>
相关作者：姚丽谢红靳秋月陈立军王静更多>>
相关机构：武警医学院太原市第三人民医院山西医科大学山西省肿瘤医院更多>>
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相关基金：国家自然科学基金广东省自然科学基金广西壮族自治区自然科学基金中国博士后科学基金更多>>
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NUMB endocytic adaptor protein(NUMB)mediates the anti-hepatic fibrosis effect of artesunate(ART)by inducing senescence in hepatic stellate cells(HSCs)
《Chinese Journal of Natural Medicines》2025年第3期322-333,共12页Yangling Qiu Yujia Li Mengran Li Yingqian Wang Min Shen Jiangjuan Shao Feng Zhang Xuefen Xu Feixia Wang Zili Zhang Shizhong Zheng 
supported by the National Natural Science Foundation of China(Nos.82474164,82374124,82073914,82173874,82274185,82305046 and 82304902);the Natural Science Foundation of Jiangsu Province(Nos.BK20230458 and BK20220467);the General Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.23KJB310017);Young Elite Scientists Sponsorship Program by CACM(No.2022-QNRC2-B15).
Developing and identifying effective medications and targets for treating hepatic fibrosis is an urgent priority.Our previous research demonstrated the efficacy of artesunate(ART)in alleviating liver fibrosis by elimi...
关键词：Hepatic stellate cells NUMB endocytic adaptor protein SENESCENCE ARTESUNATE UBIQUITYLATION Liver fibrosis 
A self-assembled nanomicelle-based "one stone for two birds" strategy for precision therapy of hepatic ischemia-reperfusion injury
《Nano Research》2025年第2期627-640,共14页Mengyuan Yu Jiongjie Yu Yujie Zhou Zhi Liang Hong Tang Changbiao Li Qingyang Que Hangxiang Wang Haiyang Xie Xiao Xu 
This research gained support from the National Key Research and Development Program of China(No.2021YFA1100500);the Major Research Plan of the National Natural Science Foundation of China(No.92159202);the National Natural Science Foundation of China(Nos.32171368 and 81930016);State Key Laboratory for Diagnosis and Treatment of Infectious Diseases(No.zz202310);the Non profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2023-PT320-02);the International Science and Technology Cooperation Project of Zhejiang province.
Hepatic ischemia-reperfusion injury(IRI)is an intricate and inevitable physiological event occurred in the liver transplantation(LT)and it is of paramount importance to devise novel and efficient methods to ameliorate...
关键词：carvacrol(CAR) artesunate(ART) nanoparticles ischemia-reperfusion injury(IRI) ferroptosis 
Artesunate Induces Ferroptosis in Hepatic Stellate Cells and Alleviates Liver Fibrosis via the ROCK1/ATF3 Axis
《Journal of Clinical and Translational Hepatology》2024年第1期36-51,共16页Yingqian Wang Yujia Li Yangling Qiu Min Shen Ling Wang Jiangjuan Shao Feng Zhang Xuefen Xu Zili Zhang Mei Guo Shizhong Zheng 
supported by the National Natural Science Foundation of China(No.82000572,82073914,82173874,82274185);the Natural Science Foundation of Jiangsu Province(No.BK20220467,BK20200840);the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.22KJB310013,19KJA310005);the Joint Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and Yangtze River Pharmaceutical(No.JKLPSE202005);the Natural Science Foundation of Nanjing University of Chinese Medicine(No.NZY82000572);Nanjing Pharmaceutical Association-Changzhou Fourth Pharmaceutical Hospital Pharmaceutical Research Fund(NO.2021YX030);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.SJCX22_0792).
Background and Aims:Development of fibrosis in chronic liver disease requires activation of hepatic stellate cells(HSCs)and leads to a poor outcome.Artesunate(Art)is an ester derivative of artemisinin that can induce ...
关键词：Ferroptosis Liver fibrosis Antioxidant system ATF3 ROCK1 
Effect of artesunate on reducing renal and intestinal injury after cardiopulmonary resuscitation in porcine
《China Medical Abstracts(Internal Medicine)》2023年第4期201-202,共2页章杰 
Objective To investigate the effect of artesunate(ART)on renal and intestinal injury aftercardiopulmonary resuscitation(CPR)in porcine,and to explore its mechanism.Methods A total of 24 healthy male white porcines wer...
关键词：RESUSCITATION ARTESUNATE mechanism 
The Combination of Artesunate and Paclitaxel in 1:1 Ratio Induces Apoptosis and Morphology Change on Human Prostate Cancer Cell Lines
《Pharmacology & Pharmacy》2023年第11期482-492,共11页Juan Fabian Taylor Pierce Shenell Brown Jazmyne Smith Dolapo Adedeji Gloria Payne 
The combination of Artesunate (ART) and Paclitaxel (PTX) in two human prostate cancer (PCa) cell lines (PC-3 and LNCaP) was evaluated to investigate the effects on proliferation, apoptosis and morphological changes. T...
关键词：COMBINATION Prostate Cancer ARTESUNATE PACLITAXEL Anticancer Activities 
Research progress of artesunate in diabetes and its complications
《Traditional Medicine Research》2023年第5期44-51,共8页Yuan-Hui Guo Lu-Lu Chen Ying LI Jia-Jia Duan Chuan-Xin Liu Hong-Wei Jiang 
Diabetes is a metabolic disease characterized by abnormally elevated blood glucose levels.Persistent hyperglycemia leads to diabetic nephropathy,diabetic retinopathy,diabetes with periodontal disease and other diabeti...
关键词：ARTESUNATE DIABETES diabetic complications islet cells glycolipid metabolism ANTI-INFLAMMATORY IMMUNOREGULATION 
Single-cell RNA sequencing deciphers the mechanism of sepsis-induced liver injury and the therapeutic effects of artesunate被引量：6
《Acta Pharmacologica Sinica》2023年第9期1801-1814,共14页Xue-ling He Jia-yun Chen Yu-lin Feng Ping Song Yin Kwan Wong Lu-lin Xie Chen Wang Qian Zhang Yun-meng Bai Peng Gao Piao Luo Qiang Liu Fu-long Liao Zhi-jie Li Yong Jiang Ji-gang Wang 
support from the Establishment of Sino-Austria“Belt and Road”Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research (2020YFE0205100);the National Key Research and Development Program of China (2020YFA0908000 and 2022YFC2303600);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine (ZYYCXTD-C-202002);the National Natural Science Foundation of China (82141001,82274182,82074098 and 82173914);the CACMS Innovation Fund (CI2021A05101 and CI2021A05104);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences (CI2021B014);the Science and Technology Foundation of Shenzhen (JCYJ20210324115800001);the Fundamental Research Funds for the Central Public Welfare Research Institutes (ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-YQ-052,ZZ14-FL-002,ZZ14-ND-010 and ZZ15-ND-10);the Shenzhen Governmental Sustainable Development Fund (KCXFZ20201221173612034);the Shenzhen Key Laboratory of Kidney Diseases (ZDSYS201504301616234);the Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties (SZGSP001).
Liver,as an immune and detoxification organ,represents an important line of defense against bacteria and infection and a vulnerable organ that is easily injured during sepsis.Artesunate(ART)is an anti-malaria agent,th...
关键词：SEPSIS scRNA-seq ARTESUNATE liver hepatic endothelial cells macrophages LYMPHOCYTES NEUTROPHILS 
Single-cell transcriptome analysis reveals the regulatory effects of artesunate on splenic immune cells in polymicrobial sepsis被引量：2
《Journal of Pharmaceutical Analysis》2023年第7期817-829,共13页Jiayun Chen Xueling He Yunmeng Bai Jing Liu Yin Kwan Wong Lulin Xie Qian Zhang Piao Luo Peng Gao Liwei Gu Qiuyan Guo Guangqing Cheng Chen Wang Jigang Wang 
support by the Establishment of Sino-Austria“Belt and Road”Joint Laboratory on Traditional Chinese Medicine for Severe Infectious Diseases and Joint Research,China(Grant No.:2020YFE0205100);the National Key Research and Development Program of China(Grant Nos.:2020YFA0908000,2022YFC2303600);the Distinguished Expert Project of Sichuan Province Tianfu Scholar(Grant No.:CW202002);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine,China(Grant No.:ZYYCXTD-C-202002);the National Natural Science Foundation of China(Grant Nos.:82141001,82274182,82074098,82173914);the China Academy of Chinese Medical Sciences(CACMS)Innovation Fund,China(Grant Nos.:CI2021A05101,CI2021A05104);the Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(Grant No.:CI2021B014);the Science and Technology Foundation of Shenzhen,China(Grant No.:JCYJ20210324115800001);the Science and Technology Foundation of Shenzhen,China(Shenzhen Clinical Medical Research Center for Geriatric Diseases),the National Key R&D Program of China Key Projects for International Cooperation on Science,Technology and Innovation(Grant No.:2020YFE0205100);the Fundamental Research Funds for the Central Public Welfare Research Institutes,China(Grant Nos.:ZZ14-YQ-050,ZZ14-YQ-051,ZZ14-YQ-052,ZZ14-FL-002,ZZ14-ND-010,ZZ15-ND-10),Shenzhen Governmental Sustainable Development Fund,China(Grant No.:KCXFZ20201221173612034);Shenzhen key Laboratory of Kidney Diseases,China(Grant No.:ZDSYS201504301616234);Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties,China(Grant No.:SZGSP001).
Sepsis is characterized by a severe and life-threatening host immune response to polymicrobial infection accompanied by organ dysfunction.Studies on the therapeutic effect and mechanism of immunomodulatory drugs on th...
关键词：ARTESUNATE SEPSIS Single-cell RNA sequencing Immunomodulatory activity 
Tumor microenvironment-responsive artesunate loaded Z-scheme heterostructures for synergistic photo-chemodynamic therapy of hypoxic tumor被引量：1
《Asian Journal of Pharmaceutical Sciences》2023年第3期37-48,共12页Jie Lv Xiaoyu Wang Xue Zhang Runpei Xu Shuyang Hu Shuangling Wang Meng Li 
Financial support was provided by the National Natural Science Foundation of China(grant no.21807024);the Youth Top-notch Talents Supporting Plan of Hebei Province(QNBJ19004);Scientific Research Foundation of Hebei Province for the Returned Overseas Chinese Scholars(C20220508);the Science and Technology Project of Hebei Education Department(no.ZD2021072);the Central Guidance on Local Science and Technology Development Fund of Hebei Province(226Z2601G);Science Fun for Creative Research Groups of Natural Science Foundation of Hebei Province(no.H2020206474);supported by the Postdoctoral Fund of Hebei Medical University.
Tumor microenvironment(TME)with the particular features of severe hypoxia,insufficient endogenous H2O2,and overexpression of glutathione(GSH)markedly reduced the antitumor efficacy of monotherapy.Herein,a TME-responsi...
关键词：Hypoxia Z-scheme heterostructure ARTESUNATE Tumor microenvironment Glutathione peroxidase 4 Synergistic therapy 
Retinal safety and toxicity study of artesunate in vitro and in vivo
《Advances in Ophthalmology Practice and Research》2023年第2期47-54,共8页Bing-Wen Lu Yu-Xiang Liang Jin-Feng Liu Zhong-Qing Sun Kwok-Fai So Kin Chiu 
supported by Midstream Research Programme for Universities,Hong Kong to Kin Chiu(Project No:MRP-092–17X).
Background:Artesunate(ART),a member of the artemisinin family,possesses multi-properties,including antiinflammation,anti-oxidation,and anti-tumor.ART was recently reported to show anti-neovascularization effect on the...
关键词：ARTESUNATE SAFETY RETINA MICROGLIA 
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