National Natural Science Foundation of China(31988101 to YGC,92354306 to YL);National Key Research and Development Program of China(2023YFA1800603);Natural Science Foundation of Jiangxi Province(20224ACB209001);Beijing Science and Technology Plan(Z231100007223006);Shenzhen Medical Research Fund(B2302022)to YGC.
Intestinal epithelial cells(IECs)are pivotal for maintaining intestinal homeostasis through self-renewal,proliferation,differentiation,and regulated cell death.While apoptosis and necroptosis are recognized as distinc...
supported by the Capital’s Funds for Health Improvement and Research(CFH)(Nos.2020-1-2031 and 2020-2-4082,China);State Key Laboratory of Respiratory Health and Multimorbidity.
Amino acid metabolic remodeling is a hallmark of cancer,driving an increased nutritional demand for amino acids.Amino acids are pivotal for energetic regulation,biosynthetic support,and homeostatic maintenance to stim...
supported by grants from the National Science Fund for Distinguished Young Scholars(82325011);the Joint Funds of the National Natural Science Foundation of China(U22A20288);the National Key Research and Development Project(2018YFA0800404);the National Natural Science Foundation of China(81970736);the Key-Area Clinical Research Program of Southern Medical University(LC2019ZD010 and 2019CR022).
Atherosclerosis is the major contributor to cardiovascular mortality worldwide.Alternate day fasting(ADF)has gained growing attention due to its metabolic benefits.However,the effects of ADF on atherosclerotic plaque ...
supported by the National Natural Science Foundation of China(No.82000572,82073914,82173874,82274185);the Natural Science Foundation of Jiangsu Province(No.BK20220467,BK20200840);the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.22KJB310013,19KJA310005);the Joint Project of Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica and Yangtze River Pharmaceutical(No.JKLPSE202005);the Natural Science Foundation of Nanjing University of Chinese Medicine(No.NZY82000572);Nanjing Pharmaceutical Association-Changzhou Fourth Pharmaceutical Hospital Pharmaceutical Research Fund(NO.2021YX030);Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.SJCX22_0792).
Background and Aims:Development of fibrosis in chronic liver disease requires activation of hepatic stellate cells(HSCs)and leads to a poor outcome.Artesunate(Art)is an ester derivative of artemisinin that can induce ...