PHENYLALANINE

作品数：81被引量：146H指数：6
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Erratum to “Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis” [Acta Pharm Sin B 14 (2024) 3493-3512]
《Acta Pharmaceutica Sinica B》2024年第11期5088-5088,共1页Longhao Cheng Xiaoxue Wang Aijun Liu Ying Zhu Hu Cheng Jiangling Yu Lili Gong Honglin Liu Guolin Shen Lihong Liu 
The publisher regrets that one Supporting Information is missed during publication.The publisher would like to apologise for any inconvenience caused.
关键词：HOMEOSTASIS DEPRIVATION 
Impact of ozonation on disinfection byproducts formation from phenylalanine during chlorination
《Journal of Environmental Sciences》2024年第10期199-211,共13页Sinong Huang Hongwei Liu Kunming Wei Liang Zhang Xiaoyan Ma Qingsong Li Xueyan Li Andrea M.Dietrich 
This research is supported by the National Natural Science Foundation of China(No.51678527);the Natural Science Foundation of Zhejiang Province of China(No.LY19E080019);the Xinmiao Talent Program of Zhejiang Province(No.2022R403C093);Engineering Research Center of Ministry of Education for Renewable Energy Infrastructure Construction Technology.
As a strong oxidizing agent,ozone is used in some water treatment facilities for disinfection,taste and odor control,and removal of organic micropollutants.Phenylalanine(Phe)was used as the target amino acid to compre...
关键词：OZONE Amino acids CHLORINATION Disinfection by-products 
Amphipathic Phenylalanine-Induced Nucleophilic-Hydrophobic Interface Toward Highly Reversible Zn Anode被引量：1
《Nano-Micro Letters》2024年第9期95-109,共15页Anbin Zhou Huirong Wang Fengling Zhang Xin Hu Zhihang Song Yi Chen Yongxin Huang Yanhua Cui Yixiu Cui Li Li Feng Wu Renjie Chen 
supported by the Joint Funds of the National Natural Science Foundation of China(U2130204);the National Natural Science Foundation of China(52002022);the Young Elite Scientists Sponsorship Program by CAST(YESS20200364);the Beijing Outstanding Young Scientists Program(BJJWZYJH01201910007023).
Aqueous Zn^(2+)-ion batteries(AZIBs),recognized for their high security,reliability,and cost efficiency,have garnered considerable attention.However,the prevalent issues of dendrite growth and parasitic reactions at t...
关键词：Zn anode PHENYLALANINE Adsorption energy Solvation sheath 
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis
《Acta Pharmaceutica Sinica B》2024年第8期3493-3512,共20页Longhao Cheng Xiaoxue Wang Aijun Liu Ying Zhu Hu Cheng Jiangling Yu Lili Gong Honglin Liu Guolin Shen Lihong Liu 
supported by the Capital’s Funds for Health Improvement and Research(CFH)(Nos.2020-1-2031 and 2020-2-4082,China);State Key Laboratory of Respiratory Health and Multimorbidity.
Amino acid metabolic remodeling is a hallmark of cancer,driving an increased nutritional demand for amino acids.Amino acids are pivotal for energetic regulation,biosynthetic support,and homeostatic maintenance to stim...
关键词：Multiple myeloma PHENYLALANINE Amino acid metabolism Nutrient deprivation Cancer therapy Endoplasmic reticulum stress ATF3 Apoptosis 
Programmable double-unlock nanocomplex self-supplies phenylalanine ammonia-lyase for precise phenylalanine deprivation of tumors
《Chinese Chemical Letters》2024年第8期455-459,共5页Chunqing Ou Meijia Xiao Xinyue Zheng Xianzhou Huang Suleixin Yang Yingying Leng Xiaowei Liu Xiuqi Liang Linjiang Song Yanjie You Shaohua Yao Changyang Gong 
supported by funds of Sichuan Province for Distinguished Young Scholar(No.2021JDJQ0037);the National Natural Science Foundation of China(No.82172094).
Essential amino acids(EAAs)deprivation is a potential antitumor approach because EAAs are critical for tumor growth.To efficiently inhibit tumor growth,continuous deprivation of EAAs is required,how-ever,continuous de...
关键词：Programmable double-unlock Essential amino acids deprivation Phenylalanine ammonia-lyase Self-supply Gene therapy 
Phenylalanine diminishes M1 macrophage inflammation被引量：1
《Science China(Life Sciences)》2023年第12期2862-2876,共15页Qingzhuo Zhang Siyuan Chen Yan Guo Fang He Jian Fu Wenkai Ren 
supported by the National Natural Science Foundation of China (32225047,31922079);the Laboratory of Lingnan Modern Agriculture Project (NT2021005)。
Emerging evidence suggests that amino acids dictate the effector functions of immune cells;however, whether and how phenylalanine(Phe) orchestrates the polarization of macrophages is not understood. Here, we determine...
关键词：IL-1β MACROPHAGE PHENYLALANINE succinyl-CoA VALINE 
Efficacy of electroacupuncture stimulating Shenmen(HT7),Baihui(GV20),Sanyinjiao(SP6)on spatial learning and memory deficits in rats with insomnia induced by para-chlorophenylalanine:a single acupoint vs combined acupoints被引量：3
《Journal of Traditional Chinese Medicine》2023年第4期704-714,共11页QIAO Lina SHI Yinan TAN Lianhong JIANG Yanshu YANG Yongsheng 
“973”Program of the Ministry of Science and Technology of China:Research on Acupoint Optimization,Combination and Evaluation Methods(No.2014CB543103);the SelfSelected Research Program from of China Academy of Chinese Medical Sciences:Study on the Mechanism of Central Amygdala Nucleus Mediated Electroacupuncture on Relieving Chronic Pain and Related Aversive Mood(No.ZZ13-YQ-063)。
OBJECTIVE:To investiage the effect of electroacupuncture(EA)at a single acupoint of Shenmen(HT7),Baihui(GV20),Sanyinjiao(SP6)and at combined acupoints of Shenmen(HT7)and Baihui(GV20)and Sanyinjiao(SP6)on the PKA/CREB ...
关键词：sleep initiation and maintenance disorders learning memory hippocampus neuronal plasticity acupoints combination 
Unrelated to phenylalanine: Feeding studies provide new insight into salicylic acid biosynthesis
《Journal of Integrative Plant Biology》2023年第4期879-880,共2页Jingjing Tan Ping He De‐Yu Xie 
How plants produce the important defense hormone salicylic acid(SA)has been studied for almost 50 years.The current understanding is that in land plants,SA is biosynthesized from chorismate through the isochorismate(I...
关键词：PHENYLALANINE INSIGHT AMMONIA 
Salicylic acid biosynthesis is not from phenylalanine in Arabidopsis被引量：4
《Journal of Integrative Plant Biology》2023年第4期881-887,共7页Jie Wu Wentao Zhu Qiao Zhao 
supported by the National Key Research and Development Program of China(2021YFD2201000,2019YFA0903900);National Natural Science Foundation of China(31870273);Shenzhen Key Laboratory of Synthetic Genomics(ZDSYS201802061806209);The Strategic Priority Research Program of the Chinese Academy of Sciences(XDPB18)。
The phytohormone salicylic acid(SA)regulates biotic and abiotic stress responses in plants.Two distinct biosynthetic pathways for SA have been well documented in plants:the isochorismate(IC)pathway in the chloroplast ...
关键词：benzoic acid IC pathway isotopic labeling PAL pathway salicylic acid 
From design to biological mechanism evaluation of phenylalanine-bearing HIV-1 capsid inhibitors targeting a vital assembly interface被引量：2
《Chinese Chemical Letters》2023年第3期361-366,共6页Shujing Xu Lin Sun Waleed A.Zalloum Xujie Zhang Tianguang Huang Dang Ding Yucen Tao Fabao Zhao Shenghua Gao Dongwei Kang Erik De Clercq Christophe Pannecouque Alexej Dick Simon Cocklin Xinyong Liu Peng Zhan 
financial support from the National Natural Science Foundation of China(NSFC,Nos.82173677,81773574);the Key Project of NSFC for International Cooperation(No.81420108027);the Shandong Provincial Key Research and Development Project(No.2019JZZY021011);the Science Foundation for Outstanding Young Scholars of Shandong Province(No.ZR2020JQ31);NIH/NIAID grant(No.R01AI150491,Cocklin,PI,Salvino,Co-I)。
HIV-1 capsid protein(CA) has emerged as a promising target for antiviral treatment considering its structural and regulatory roles in HIV-1 replication. Here, we disclose the design, synthesis, biological assessment, ...
关键词：HIV-1 Capsid inhibitor ASSEMBLY NTD-CTD interface Drug design 
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