转录因子ATF3与前列腺癌临床相关性的分析研究  

Clinical analyses of transcriptional factor ATF3 in prostate cancer

作　　者：徐凌凡[1] 丁和康 施浩强[1] 杨诚[1] 邰胜[1] XU Ling-fan;DING He-kang;SHI Hao-qiang(Dept of Urology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui)

机构地区：[1]安徽医科大学第一附属医院泌尿外科,安徽合肥230022

出　　处：《安徽医专学报》2024年第2期90-93,共4页Journal of Anhui Medical College

基　　金：国家自然科学基金(编号:82272886);安徽省教育厅高校优秀青年科研项目(编号:2022AH030118);安徽省转化医学研究院科研基金项目(编号:2022zhyx-C37)。

摘　　要：目的:探究转录因子ATF3与前列腺癌的临床相关性,了解ATF3在前列腺癌组织中的表达以及其表达强度对前列腺癌患者预后的影响。方法:采用公共数据库挖掘的方法分析ATF3在前列腺癌组织中的突变情况以及ATF3在正常前列腺组织以及前列腺癌组织中的表达情况,kaplan-meier方法分析ATF3的表达强度与前列腺癌患者临床预后的相关性;免疫组化染色验证ATF3在正常前列腺组织和前列腺癌组织中的蛋白表达;患者临床信息分析ATF3的表达高低与前列腺癌临床特征的关联。结果:ATF3在前列腺癌组织中表现为高扩增突变,且ATF3在前列腺癌组织中的表达明显高于正常前列腺组织;ATF3与前列腺癌疾病的发生、进展(病灶转移)相关;高表达ATF3的前列腺癌患者预后较差。结论:ATF3的表达强度与前列腺癌的发生发展相关,可作为前列腺癌诊断及预后判断的重要指标。Objective:To investigate the clinical relevance of ATF3 and prostate cancer.Methods:Bioinformatic analyses were employed to determine genetic alterations of ATF3 in prostate cancer.Immunohistochemical staining was used to validate the ATF3 expression pattern in benign prostate tissues and prostate cancer tissues.Correlation analyses were performed to show clinical relevance of ATF3 expression and clinical features.Survival outcomes were also predicted which were derived from the TCGA dataset.Results:ATF3 is significantly amplified in prostate cancer and ATF3 expression is higher in prostate cancer tissues.High ATF3 expression is associated with disease progression and metastasis.Patients with high ATF3 burden show worse clinical outcomes.Conclusions:ATF3 is closely related with disease progression and clinical outcomes which can be served as a biomarker of prostate cancer.

关 键 词：前列腺癌 ATF3 免疫组化 前列腺特异性抗原 

分 类 号：R737.25[医药卫生—肿瘤]