PURINE

作品数:73被引量:102H指数:5
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相关领域:医药卫生理学更多>>
相关作者:张礼和杨振军郑焕鑫孙超更多>>
相关机构:北京大学信息技术有限公司中国医学科学院北京协和医学院中国科学技术大学更多>>
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Metabolic mechanism of dietary factors and effect of dietary types associated with hyperuricemia:a review
《Food Science and Human Wellness》2025年第3期835-849,共15页Kaina Qiao Xuewei Zhou Lili Zhang Wangang Zhang Baoguo Sun Yuyu Zhang 
supported by the National Natural Science Foundation of China(No.32122069);Beijing Outstanding Young Scientist Program(No.BJJWZYJH01201910011025);China Postdoctoral Science Foundation(No.2023M730134)。
Globally,hyperuricemia is a growing health,social,and economic problem which could cause gout,chronic kidney diseases and other diseases.There are increasing evidences that a sensible diet makes sense to reduce the ri...
关键词:PURINE Metabolic mechanism Dietary types HYPERURICEMIA Personalized diet 
Effect of purine diet on prognosis of deep brain stimulation for Parkinson's disease
《Food Science and Human Wellness》2025年第3期1026-1033,共8页Bowen Chang Yuge Jiang Chuanxing Feng Bowen Li Jiaming Mei Chaoshi Niu 
Uric acid(UA)is a naturally antioxidant that is strongly associated with the development and progression of Parkinson's disease(PD).The purine diet is an important exogenous pathway that modulates blood UA levels.Deep...
关键词:Purine diet NUTRITION Parkinson’s disease Deep brain stimulation Brain connectivity 
PURINE PERMEASE 4 regulates plant height in maize
《Journal of Genetics and Genomics》2025年第3期446-448,共3页Yuchen Huang Yuehui Zhang Xiaofeng Cai Shui Wang 
supported by grants from the National Natural Science Foundation of China(32270290);the Shanghai Engineering Research Center of Plant Germplasm Resources(17DZ2252700).
Plant height is an important trait that affects the crop yield and overall productivity.The Green Revolution,which began in the 1960s,brought about a remarkable surge in grain production,largely credited to the introd...
关键词:plant height crop yield productivity green revolution dwarf variantsshort MAIZE green revolutionwhich purine permease 
植物PUP转运蛋白研究进展
《植物生理学报》2024年第11期1613-1619,共7页赵玥 沈晓凤 孙超 
中央高校基本科研业务费专项资金(3332023050)。
植物PUP(purine uptake permease)转运蛋白是植物体内常见的转运蛋白之一,主要参与了植物激素和生物碱等物质的吸收转运过程,是转运系统中的关键组分,对调节生长发育和应对非生物胁迫等具有重要的作用。本文对PUP家族的发现、分类、结...
关键词:PUP(purine uptake permease) 结构 功能 调控 
Fatty acid oxidation-induced HIF-1α activation facilitates hepatic urate synthesis through upregulating NT5C2 and XDH被引量:2
《Life Metabolism》2024年第5期17-31,共15页Ningning Liang Xuan Yuan Lili Zhang Xia Shen Shanshan Zhong Luxiao Li Rui Li Xiaodong Xu Xin Chen Chunzhao Yin Shuyuan Guo Jing Ge Mingjiang Zhu Yongzhen Tao Shiting Chen Yongbing Qian Nicola Dalbeth Tony RMerriman Robert Terkeltaub Changgui Li Qiang Xia Huiyong Yin 
funded by grants from the National Key Research and Development Program of China(2022YFC2503300 and 2018YFA0800300);the National Natural Science Foundation of China(32030053 and 32241017);the startup fund from City University of Hong Kong(9380154);the RGC Theme-based Research Scheme(8770011);the TBSC Project fund,and Shenzhen Medical Research Fund(B2302042);R.T.was supported by the VA Research Service(I01 BX005927)and NIH(PAG007996).
Dyslipidemia affects approximately half of all people with gout,and prior Mendelian randomization analysis suggested a causal role for elevated triglycerides in hyperuricemia(HU),but the underlying mechanisms remain e...
关键词:DYSLIPIDEMIA HYPERURICEMIA PURINE HYPOXANTHINE metabolic flux 
Probiotics administration alleviates cognitive impairment and circadian rhythm disturbance induced by sleep deprivation
《Food Science and Human Wellness》2024年第4期1951-1961,共11页Peijun Tian Yunfei Hou Zheng Wang Jiaona Jiang Xin Qian Zhihao Qu Jianxin Zhao Gang Wang Wei Chen 
the financial support from Natural Science Foundation of Jiangsu Province(BK20210456);the National Natural Science Foundation of China(32201988,31972052,32021005,31820103010);the Fundamental Research Funds for the Central Universities(JUSRP22006,JUSRP51501);the China National Postdoctoral Program for Innovative Talents(BX2021114);China Postdoctoral Science Foundation(2021M691290);the Postdoctoral Science Foundation of Jiangsu Province(2021K127B);the Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province。
Gut microbiome is indispensable for maintaining normal brain function.Specifically,gut microbiota plays a causal role in sleep deprivation(SD)-induced cognitive impairment.In this study,neurobehavioral effects of the ...
关键词:BIFIDOBACTERIUM SLEEP Circadian rhythm PURINE Gut microbiome 
A novel strain of Levilactobacillus brevis PDD-5 isolated from salty vegetables has beneficial effects on hyperuricemia through anti-inflammation and improvement of kidney damage被引量:1
《Food Science and Human Wellness》2024年第2期898-908,共11页Jue Xu Maolin Tu Xiankang Fan Yuxing Guo Tao Zhang Xiaoqun Zeng Zhendong Cai Zhen Wu Daodong Pan 
the National Natural Science Foundation of China(31972048,32272339);the National Key R&D Program of China(2021YFD2100104)for financial support。
Hyperuricemia is a metabolic disorder caused by abnormal purine metabolism,resulting in abnormally high serum uric acid.In this study,a novel Levilactobacillus brevis PDD-5 isolated from salty vegetables was verified ...
关键词:Lactic acid bacteria Purine nucleoside HYPERURICEMIA Uric acid nephropathy 
N,S,Br co-doped carbon dots:One-step synthesis and fluorescent detection of 6-mercaptopurine in tablet
《Journal of Pharmaceutical Analysis》2024年第2期291-293,共3页Qi Wang Ying Cheng Lifeng Ding Shengling Li Jie Zhang Yulan Niu Ziye Jing 
support of Taiyuan Institute of Technology Scientific Research Initial Funding,China(Grant No.:2022KJ058);the Basic Research Project of Shanxi Province,China(Project No.:202203021212331);the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi,China(Program Nos.:2022L529 and 2022L532);the Fund for Shanxi“1331”Project,China.
6-mercaptopurine(6-MP),a purine derivative(3,7-dihydropurine-6-thione),has been utilized as an effective immunosuppressive drug for clinically treating leukemia and other autoimmune diseases[1].6-MP and its correspond...
关键词:PURINE SYNTHESIS eliminate 
Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism
《Journal of Pharmaceutical Analysis》2023年第12期1562-1576,共15页Jiajun Chen Tian Li Dehua Huang Wenxia Gong Junsheng Tian Xiaoxia Gao Xuemei Qin Guanhua Du Yuzhi Zhou 
This work was financially supported by the National Natural Science Foundation of China(Grant Nos.:82074323 and 81673572);Key Research and Development Program of Shanxi Province(Grant No.:202102130501010);Innovation Project for Graduate Students in Shanxi Province(Grant No.:2022Y162);the Major Science and Technology Project for“Significant New Drugs Creation”(Grant No.:2017ZX09301047);Research Project Supported by Shanxi Scholarship Council of China(Grant No.:2020019).
Chaigui granules(CG)are a compound composed of six herbal medicines with significant antidepressant effects.However,the antidepressant mechanism of CG remains unclear.In the present study,we attempted to elucidate the...
关键词:Chaigui granules Traditional Chinese medicine Antidepressant mechanism Purine metabolism Purinergic signaling 
Differential accumulation mechanisms of purine alkaloids and catechins in Camellia ptilophylla,a natural theobromine-rich tea
《Beverage Plant Research》2023年第1期128-136,共9页Chentao Ying Jiawen Chen Jiahao Chen Peng Zheng Caibi Zhou Binmei Sun Shaoqun Liu 
supported by the Natural Science Foundation of Guangdong Province(2023A1515010786,2022A1515111141).
Tea is consumed worldwide due to its charming flavor and the refreshing effects conferred by caffeine.Caffeine however has undesirable side effects,such as sleep disturbance.Camellia ptilophylla is known for its low c...
关键词:ALKALOIDS PURINE attributed 
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