N,S,Br co-doped carbon dots:One-step synthesis and fluorescent detection of 6-mercaptopurine in tablet  

作　　者：Qi Wang Ying Cheng Lifeng Ding Shengling Li Jie Zhang Yulan Niu Ziye Jing 

机构地区：[1]Chemistry&Chemical Engineering Department,Taiyuan Institute of Technology,Taiyuan,030008,China [2]Department of Anesthesiology,First Hospital of Shanxi Medical University,Taiyuan,030001,China

出　　处：《Journal of Pharmaceutical Analysis》2024年第2期291-293,共3页药物分析学报（英文版）

基　　金：support of Taiyuan Institute of Technology Scientific Research Initial Funding,China(Grant No.:2022KJ058);the Basic Research Project of Shanxi Province,China(Project No.:202203021212331);the Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi,China(Program Nos.:2022L529 and 2022L532);the Fund for Shanxi“1331”Project,China.

摘　　要：6-mercaptopurine(6-MP),a purine derivative(3,7-dihydropurine-6-thione),has been utilized as an effective immunosuppressive drug for clinically treating leukemia and other autoimmune diseases[1].6-MP and its corresponding metabolites can suppress the function of RnaseH,and thus they are cytotoxic and threaten the human health[2].Therefore,the accurate quantification of 6-MP is crucial.To date,researchers continue to expend considerable effort in developing 6-MP detection methods.Fluorescence analysis eliminates disadvantages,such as toxic solvents,expensive equipment.

关 键 词：PURINE SYNTHESIS eliminate 

分 类 号：R114[医药卫生—卫生毒理学]