GLYCOPROTEINS

作品数：59被引量：156H指数：6
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Phospholipase PlcH is involved in the secretion of cell wall glycoproteins and contributes to the host immune response of Aspergillus fumigatus
《mLife》2024年第4期537-550,共14页Jinbin Hao Yin Guo Hui Zhou Haomiao Ouyang Jinghua Yang Wenxia Fang Cheng Jin 
supported by the National Key Research and Development Program of China(2021YFC2300400);the National Natural Science Foundation of China(32371337).
Glycosylphosphatidylinositol(GPI)anchoring is one of the conserved posttranslational modifications in eukaryotes that attach proteins to the plasma membrane.In fungi,in addition to plasma membrane GPI‐anchored protei...
关键词：Aspergillus fumigatus cell wall protein GPI‐anchored protein immune response macrophage killing 
The role of glycoproteins in nasopharyngeal carcinoma pathogenesis
《广西医科大学学报》2024年第9期1261-1272,共12页Liudmila Matskova Elvira Grigorieva 
Nasopharyngeal carcinoma(NPC)is a malignant tumor arising from the nasopharyngeal epithelium.It consists of undifferentiated squamous cells in the nasopharynx.This type of epithelial cell neoplasm is globally distribu...
关键词：nasopharyngeal carcinoma GLYCOPROTEIN PATHOGENESIS 
Encouraging Solution to the Problem of Synthesizing Protein α-Thioester被引量：1
《Chinese Journal of Chemistry》2024年第10期1114-1120,共7页Xinliang Liu Zijun Gao Jie Zhao Farong Ye Ping Huang Ping Wang 
supported by the National Science Fund for Distinguished Young Scholars(22225701);the Interdisciplinary Program of Shanghai Jiao Tong University(20230102);the National Natural Science Foundation of China(22077080,92253302 and 22275122);the Shanghai Pilot Program for Basic Research Shanghai Jiao Tong University(21TQ1400210);the Special Projects of the Central Government in Guidance of Local Science and Technology Development(2021Szvup077);the China Post-doctoral Science Foundation(2023M732214).
Expressed protein ligation(EPL)provides a powerful tool to access large-size proteins with precise structures.Existing methods for constructing the critical protein thioester for EPL have predominantly relied on the r...
关键词：DESULFURIZATION GLYCOPROTEINS GLYCOPEPTIDES Protein expression Peptide thioester 
Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm被引量：1
《Signal Transduction and Targeted Therapy》2023年第11期5444-5453,共10页Ming Cui Ya Hu Zejian Zhang Tianqi Chen Menghua Dai Qiang Xu Junchao Guo Taiping Zhang Quan Liao Jun Yu Yupei Zhao 
This work was supported by grants National Key R&D Program of China(No.2020YFC2002702);National High Level Hospital Clinical Research Funding(2022-PUMCH-D-001);Beijing Natural Science Foundation(No.7224340);the Fundamental Research Funds for the Central Universities(No.3332022006);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2018PT32014).
Pancreatic cystic neoplasms(PCNs)are recognized as precursor lesions of pancreatic cancer,with a marked increase in prevalence.Early detection of malignant PCNs is crucial for improving prognosis;however,current diagn...
关键词：NEOPLASMS offering utilized 
Recent Advances in Glycopeptide and Glycoprotein Synthesis:A Refined Synthetic Probe towards the Biological World被引量：1
《Chinese Journal of Chemistry》2023年第16期2010-2024,共15页Haoru Zhuang Huiran Hao Yongshun Qiu Jinjuan Gan Tianlu Li 
Shenzhen Fundamental Research Program(RCBS20200714114957255);the National Natural Science Foundation of China(Grant No.22177061);the National Key Research and Development Program of China(2018YFA0902000);the Open Projects Fund of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology(2021CCG01).
Comprehensive Summary Protein glycosylation is the most complex and diverse form of post-translational modification in human body.Meanwhile,glycosylation of peptides and proteins emerges as a promising strategy to imp...
关键词：GLYCOPROTEINS GLYCOPEPTIDES GLYCOSYLATION Total synthesis BIOSYNTHESIS Structure-activity relationships 
可去除染料--N-聚糖多方法深入分析中的缺失环节被引量：2
《Engineering》2023年第7期132-150,I0006,共20页Samanta Cajic RenéHennig Valerian Grote Udo Reichl Erdmann Rapp 
support from the German Federal Ministry of Education and Research(BMBF)under the project“Die Golgi Glykan Fabrik 2.0”(031A557C for Samanta Cajic and Erdmann Rapp);the European Commission(EC)under the project“HighGlycan”(278535 for RenéHennig and Erdmann Rapp);the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)under the project“The concert of dolicholbased glycosylation:from molecules to disease models”(FOR2509 for Valerian Grote and Erdmann Rapp).
As the roles of glycans in health and disease continue to be unraveled,it is becoming apparent that glycans’immense complexity cannot be ignored.To fully delineate glycan structures,we developed an integrative approa...
关键词：GLYCOPROTEINS N-GLYCANS Reversible labeling Hydrophilic interaction liquid CHROMATOGRAPHY Capillary gel electrophoresis Mass spectrometry 
In silico comparative structural and compositional analysis of glycoproteins of RSV to study the nature of stability and transmissibility of RSV A
《Systems Microbiology and Biomanufacturing》2023年第2期312-327,共16页Debanjan Mitra Pradeep K.Das Mohapatra 
The current scenario of COVID-19 makes us to think about the devastating diseases that kill so many people every year.Analysis of viral proteins contributes many things that are utterly useful in the evolution of ther...
关键词：Respiratory syncytial virus Stability Intra-protein interactions TUNNELS Drug discovery 
Structural characterization and antioxidant activity of a glycoprotein isolated from shiitake mushrooms被引量：3
《Food Bioscience》2023年第3期1072-1080,共9页Jingyi Gao Xin Li Suting Jia Hongliang Zeng Baodong Zheng 
supported by the Construction project of Integrated Scientific Research Base of the Ministry of Agriculture and the Rural Affairs“Construction of Integrated Scientific Research Base of Edible Fungi Processing and Comprehensive Utilization Technology”(Devel-opment and Reform Investment[2021]No.857);the Fujian Province colleges and universities to improve the level of education special project,"China-Ireland International Cooperation Food Materiology and Structural Design Research Center construction Fund"(Mincai Index:[2019]0761).
In this paper,the shiitake mushroom glycoprotein(SGP)was extracted from shiitake mushrooms and its structure was characterized and its antioxidant activity was investigated.SGP contained 33.42±1.75%protein and 42.59...
关键词：Shiitake mushrooms GLYCOPROTEINS Structural characterization ANTIOXIDANT 
Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins
《Journal of Pharmaceutical Analysis》2023年第3期305-314,共10页Chi Soo Park Minju Kang Ahyeon Kim Chulmin Moon Mirae Kim Jieun Kim Subin Yang Leeseul Jang Ji Yeon Jang Ha Hyung Kim 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)and funded by the Ministry of Education,Korea(Grant No.:2021R1A6A1A03044296);This study was supported by the Chung-Ang University Graduate Research Scholarship in 2022.
Sialylated N-glycan isomers withα2-3 orα2-6 linkage(s)have distinctive roles in glycoproteins,but are difficult to distinguish.Wild-type(WT)and glycoengineered(mutant)therapeutic glycoproteins,cytotoxic T lymphocyte...
关键词：Therapeutic glycoprotein SIALYLATION Linkage isomer LC-MS/MS 
Supporting Information The Impact of Borate on the Structure of Antifreeze Glycoproteins
《Chinese Journal of Chemical Physics》2021年第6期I0007-I0012,共6页Fengqin Long Tan Jin Keli Han Wei Zhuang 
Simulation convergence check.We compared the projections of the free energy landscape for each ontogyration radius(Rg)and the number of hydrogen bonds within the protein of two sets of Replicaexchange molecular dynami...
关键词：temperature Impact RADIUS 
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