Recent Advances in Glycopeptide and Glycoprotein Synthesis:A Refined Synthetic Probe towards the Biological World  

作　　者：Haoru Zhuang Huiran Hao Yongshun Qiu Jinjuan Gan Tianlu Li 

机构地区：[1]Shenzhen Research Institute of Shandong University,A301 Virtuol University Park in South District of Shenzhen,Shenzhen,Guangdong 518057,China [2]Notional Glycoengineering Research Center,Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology,NMPA Key Laboratory for Quality Research and Evaluation of Carbohydrate Based Medicine,Shandong University,Qingdao,Shandong 266237,China

出　　处：《Chinese Journal of Chemistry》2023年第16期2010-2024,共15页中国化学（英文版）

基　　金：Shenzhen Fundamental Research Program(RCBS20200714114957255);the National Natural Science Foundation of China(Grant No.22177061);the National Key Research and Development Program of China(2018YFA0902000);the Open Projects Fund of Shandong Key Laboratory of Carbohydrate Chemistry and Glycobiology(2021CCG01).

摘　　要：Comprehensive Summary Protein glycosylation is the most complex and diverse form of post-translational modification in human body.Meanwhile,glycosylation of peptides and proteins emerges as a promising strategy to improve the pharmacokinetic profile of peptide-and protein-based therapeutics.Owing to the importance of protein glycosylation,a rigorous evaluation of the relationship between the precise structure and biological function of glycoproteins has to be performed.Recently,chemical synthesis,chemoenzymatic synthesis and semisynthesis strategies have attracted extensive attentions towards the preparation of structurally defined glycopeptides and glycoproteins;the obtained synthetic glycoforms thus enable the thorough investigation of specific effects of protein glycosylation.

关 键 词：GLYCOPROTEINS GLYCOPEPTIDES GLYCOSYLATION Total synthesis BIOSYNTHESIS Structure-activity relationships 

分 类 号：O62[理学—有机化学]