SIALYLATION

作品数：10被引量：14H指数：3
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相关领域：医药卫生生物学更多>>
相关机构：上海交通大学上海交通大学医学院附属新华医院更多>>
相关期刊：《Journal of Pharmaceutical Analysis》《Chinese Journal of Chemistry》《Frontiers of Medicine》《Science China Chemistry》更多>>
相关基金：国家自然科学基金中国博士后科学基金更多>>
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α2,3-Sialylation with Fucosylation Associated with More Severe Anti-MDA5 Positive Dermatomyositis Induced by Rapidly Progressive Interstitial Lung Disease
《Phenomics》2023年第5期457-468,共12页Rongrong Zhang Li Guo Jichen Sha Shuwai Chang Jiangfeng Zhao Kaiwen Wang Jiucun Wang Jianxin Gu Jing Liu Shifang Ren 
supported by grants from The National Key R&D Program of China(2022YFC3400803);the National Natural Science Foundation of China(32071276);Greater Bay Area Institute of Precision Medicine(IPM2021C005);National Postdoctoral Program for Innovative Talents(BX20190076).
Dermatomyositis(DM)is a heterogeneous autoimmune disease associated with numerous myositis specific antibodies(MSAs)in which DM with anti-melanoma differentiation-associated gene 5-positive(MDA5+DM)is a unique subtype...
关键词：DERMATOMYOSITIS Anti-melanoma differentiation-associated gene 5-positive Interstitial lung disease GLYCOSYLATION Matrix assisted laser desorption/ionization time of flight mass spectrometry 
Control of lupus activity during pregnancy via the engagement of IgG sialylation:novel crosstalk between IgG sialylation and pDC functions
《Frontiers of Medicine》2023年第3期549-561,共13页You Wang Sihan Lin Jiayue Wu Meng Jiang Jianhua Lin Yu Zhang Huihua Ding Haibo Zhou Nan Shen Wen Di 
supported by grants from the National Natural Science Foundation of China(Nos.82172918,81901494,82101768,82171767,and 81974252);the Science and Technology Commission of Shanghai Municipality(No.18441904800);the Medical-Engineering Joint Funds of Shanghai Jiao Tong University(No.YG2021GD01);the Shanghai Key Laboratory of Gynecologic Oncology(No.FKZL-2021-02);Shanghai Health Commission(No.201940284);the Clinical Scientific Research Innovation Cultivation Fund of Renji Hospital(No.PYI20-03).
Immunoglobulin(IgG)glycosylation affects the effector functions of IgG in a myriad of biological processes and has been closely associated with numerous autoimmune diseases,including systemic lupus erythematosus(SLE),...
关键词：PREGNANCY IgG glycome typeⅠinterferon systemic lupus erythematosus 
Enzymatic Synthesis of Sialyl Lactosamine Grafted Chitooligosaccharides被引量：3
《Chinese Journal of Chemistry》2023年第11期1299-1304,共6页Jun Yan Jianghua Li Zhifei Hu Xiaoyao Ma Yun Li Xihuan Hu Jinfeng Ye Wei Wang Renzhong Wan Hongzhi Cao 
supported by the National Key Research and Development Program of China(2021YFC210500 and 2022YFC2104900);the National Natural Science Foundation of China(21961142016,22277111 and 22107094);Department of Science and Technology of Shandong Province(2020CXGC010601,2021ZDSYS22 and ZR2021QB061)。
An efficient enzymatic assembly strategy was developed for the concise synthesis of structurally well-defined sialylated chitooligosaccharides.Two enzyme modules for theβ-1,3-N-acetyl-glucosaminylation andβ-1,4-gala...
关键词：CHITOOLIGOSACCHARIDES Sialylation Influenza virus GLYCOSYLATION Biocatalysis Structure-activity relationships 
Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins
《Journal of Pharmaceutical Analysis》2023年第3期305-314,共10页Chi Soo Park Minju Kang Ahyeon Kim Chulmin Moon Mirae Kim Jieun Kim Subin Yang Leeseul Jang Ji Yeon Jang Ha Hyung Kim 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)and funded by the Ministry of Education,Korea(Grant No.:2021R1A6A1A03044296);This study was supported by the Chung-Ang University Graduate Research Scholarship in 2022.
Sialylated N-glycan isomers withα2-3 orα2-6 linkage(s)have distinctive roles in glycoproteins,but are difficult to distinguish.Wild-type(WT)and glycoengineered(mutant)therapeutic glycoproteins,cytotoxic T lymphocyte...
关键词：Therapeutic glycoprotein SIALYLATION Linkage isomer LC-MS/MS 
Sialylation of TLR2 initiates osteoclast fusion被引量：3
《Bone Research》2022年第2期286-296,共11页Ce Dou Gehua Zhen Yang Dan Mei Wan Nathachit Limjunyawong Xu Cao 
supported by US National Institutes of Health grants AR 071432 (to X.C.)
The molecular control of osteoclast formation is still not clearly elucidated. Here, we show that a process of cell recognition mediated by Siglec15-TLR2 binding is indispensable and occurs prior to cell fusion in RAN...
关键词：OSTEOCLAST TLR2 INJECTION 
Sialylation is involved in cell fate decision during development, reprogramming and cancer progression被引量：6
《Protein & Cell》2019年第8期550-565,共16页Fenjie Li Junjun Ding 
National Key Research and Development Program 2016YFA (0101700) and 2017YFA0102800;the National Natural Science Foundation of China (Grant Nos. 31771639 and 81703086);Guangdong Innovative and Entrepreneurial Research Team Program 2016ZT06S029;the Fundamental Research Funds for the Central Universities (17ykzd04);Thousand Youth Talents Plan to J. Ding and J. W., the National Natural Science Foundation of China (Grant No. 31771);a project funded by China Postdoctoral Science Foundation (2017M622863).
Sialylation, or the covalent addition of sialic acid to the terminal end of glycoproteins, is a biologically important modification that is involved in embryonic development, neurodevelopment, reprogramming, oncogenes...
关键词：SIALYLATION cell FATE DEVELOPMENT REPROGRAMMING cancer 
Modulation of the stereoselectivity and reactivity of glycosylation via (p-Tol)2SO/Tf2O preactivation strategy:From O-, C-sialylation to general O-,N-glycosylation
《Chinese Chemical Letters》2018年第1期1-10,共10页Guang-Jian Liu Cui-Yun Li Xiao-Tai Zhang Wei Du Zhen-Yuan Gu Guo-Wen Xing 
financially supported by the National Natural Science Foundation of China (No. 21272027)
The synthesis of O-, C-, and N-glycoconjugates has continuously been an attractive research subject due to the growing biological importance of various glycoconjugates. In recent years, by careful changing the glycosy...
关键词：Glycosylation SialylationSulfoxideStereoselectivityNucleosicle 
A vital sugar code for ricin toxicity被引量：2
《Cell Research》2017年第11期1351-1364,共14页Jasmin Taubenschmld Johannes Stadlmann Markus Jost Tove Irene Klok.k Cory D Rillahan Andreas Leibbrandt Karl Mechtler James C Paulson Julian Jude Johannes Zuber Kirsten Sandvig Ulrich Elling Thorsten Marquardt Christian Thiel Christian Koerner Josef M Penninger 
Ricin is one of the most feared bioweapons in the world due to its extreme toxicity and easy access. Since no anti- dote exists, it is of paramount importance to identify the pathways underlying ricin toxicity. Here, ...
关键词：RICIN TOXIN FUCOSYLATION SIALYLATION Lewis X intracellular trafficking 
Possible role of sialylation of retinal protein glycans in the regulation of electroretinogram response in mice
《International Journal of Ophthalmology(English edition)》2017年第8期1217-1222,共6页Satpal Ahuja 
Supportted by Ogonfonden Synframjande Forskning,Stod Ogonforskningen,Umea(Sweden);Stiftelsen Kronprinsessan Margaretas Arbetsnamnd for synskadade(KMA,Sweden);Stiftelsen for synskadade i.f.d Malmohus Lan,Malmo(Sweden)
AIM： To evaluate if the nature, degree and extent of Siaa2-3-/Siaa2-6-sialylation of retinal protein glycans plays a possible role in the development and regulation of electroretinogram response （ERG） in mice. MET...
关键词：electroretinogram response GLYCOME lectin microarray mice retinae retinal development and degeneration 
Chemoenzymatic synthesis of α2–3-sialylated carbohydrate epitopes
《Science China Chemistry》2011年第1期117-128,共12页HUANG ShengShu YU Hai CHEN Xi 
supported by NIH grants R01GM076360 and U01CA128442
Sialic acids are common terminal carbohydrates on cell surface.Together with internal carbohydrate structures,they play important roles in many physiological and pathological processes.In order to obtain α2–3-sialyl...
关键词：CARBOHYDRATE chemoenzymatic synthesis sialic acid SIALYLATION SIALYLTRANSFERASE 
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