RICIN

作品数:33被引量:56H指数:5
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相关领域:医药卫生更多>>
相关作者:李继硕罗丕福沈倍奋柳峰松李伟更多>>
相关机构:军事医学科学院第四军医大学西南大学河北大学更多>>
相关期刊:《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《食品科技》《World Journal of Gastroenterology》更多>>
相关基金:国家自然科学基金国家高技术研究发展计划河北省自然科学基金中国科学院科研项目更多>>
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Clinical efficacy and safety of liposomal amphotericin B in the salvage treatment of invasive fungal disease in patients with hematological diseases.
《China Medical Abstracts(Internal Medicine)》2024年第4期227-227,共1页WU Yuanbing 
Objective To investigate the efficacy and safety of liposomal amphotericin B(L-AmB)for the salvage treatment of invasive fungal disease(IFD)in patients withhematologicaldiseases.MethodsDatawere retrospectively collect...
关键词:PATIENTS RICIN FUNGAL 
基于10×Genomics技术对蓖麻毒素中毒后中性粒细胞的转录组分析
《免疫学杂志》2021年第4期300-307,共8页申梦 杨晓岚 赵玲娜 姜永强 谷宏婧 王慧 
国家重点研发专项(2017YFC1200900)。
目的探究中性粒细胞在蓖麻毒素(Ricin Toxin,RT)致毒过程中的作用,寻找解毒的有效策略。方法采用10×Genomics单细胞转录组测序技术对中毒小鼠外周血单个核细胞(PBMCs)进行转录组测序及分析,并通过流式细胞术测定目的细胞亚群。结果经...
关键词:Ricin Toxin 中性粒细胞 单细胞转录组测序技术 CCRL2 
Novel small molecule retrograde transport blocker confers post-exposure protection against ricin intoxication被引量:2
《Acta Pharmaceutica Sinica B》2020年第3期498-511,共14页Xu Zhao Haixia Li Jia Li Kunlu Liu Bo Wang Yuxia Wang Xingzhou Li Wu Zhong 
the financial supports of the National Science and Technology Major Projects for"Major New Drugs Innovation and Development"(2018ZX09711003-001-001)of China.
Ricin is a highly toxic type 2 ribosome-inactivating protein(RIP)which is extracted from the seeds of castor beans.Ricin is considered a potential bioterror agent and no effective antidote for ricin exists so far.In t...
关键词:RICIN toxin Ribosome-inactivating proteins Retrograde transport Post-exposure ANTIDOTE RICIN antibody 
唾液乳杆菌素Salivaricin SJH-8基因信息与生物学特性研究被引量:1
《食品科技》2019年第8期6-12,共7页刘复荣 何敬愉 蒙海林 崔金明 
国家自然科学基金项目(31870776,31670056);广东省科技计划项目(2019B030316016,2017A030303005);广东省自然科学基金项目(2017A030313149);广州市科技计划项目(201803020035)
以实验室从水产动物白斑鱼肠道中分离鉴定的一株唾液乳杆菌SJH-8为研究对象,根据ClassIIb类抗菌肽ABP-118结构基因序列设计引物,以SJH-8基因组为模板可扩增出一段大小为702bp的基因片段,经测序和分析得出SalivaricinSJH-8结构基因与ABP-...
关键词:唾液乳杆菌 细菌素SalivaricinSJH-8 结构基因 抑菌活性 生物防腐剂 
On the Generic Taxonomy of Opisthotropis balteata(Cope, 1895)(Squamata: Colubridae: Natricinae): Taxonomic Revision of Two Natricine Genera被引量:8
《Asian Herpetological Research》2019年第2期105-128,共24页Jinlong REN Kai WANG Peng GUO Yingyong WANG Tao Thien NGUYEN Jiatang LI 
supported by the National Key Research and Development Program of China (2017YFC0505202);Strategic Priority Research Program of Chinese Academy of Sciences (XDB31000000);the National Natural Science Foundation of China (31722049, 31772434);Key Research Program of Frontier Sciences, CAS (QYZDB-SSW-SMC058);the Southeast Asia Biodiversity Research Institute, Chinese Academy of Science (Y4ZK111B01);the Youth Innovation Promotion Association of CAS;the CAS “Light of West China” Program (2018XBZG_JCTD_001);Talent Program from Organization Department of Sichuan Provincial Committee;partially supported by project BSTMV.08/16-19 to NTT
The single prefrontal configuration has historically been used as an important diagnostic character for many natricine taxa. For example, the genus Trimerodytes Cope, 1895 was long been regarded as a junior synonym of...
关键词:Paratapinophis PREFRONTAL scales Sinonatrix TAXONOMIC REVISION Trimerodytes 
A vital sugar code for ricin toxicity被引量:2
《Cell Research》2017年第11期1351-1364,共14页Jasmin Taubenschmld Johannes Stadlmann Markus Jost Tove Irene Klok.k Cory D Rillahan Andreas Leibbrandt Karl Mechtler James C Paulson Julian Jude Johannes Zuber Kirsten Sandvig Ulrich Elling Thorsten Marquardt Christian Thiel Christian Koerner Josef M Penninger 
Ricin is one of the most feared bioweapons in the world due to its extreme toxicity and easy access. Since no anti- dote exists, it is of paramount importance to identify the pathways underlying ricin toxicity. Here, ...
关键词:RICIN TOXIN FUCOSYLATION SIALYLATION Lewis X intracellular trafficking 
Influence of Metal Cations and Cholesterol on Lipid-amphotericin Membrane
《Chemical Research in Chinese Universities》2017年第3期447-453,共7页WANG Juan SUN Runguang HAO Changchun LI Tuo TIAN Yuan ZHANG Lei 
Supported by the National Natural Science Foundation of China(No.21402114).
Amphotericin B(AmB) has been widely used in antifungal therapy. AraB molecules combine with cholesterol to form pores that can be toxic to human cells, thus greatly limiting its clinical application. The interaction...
关键词:Amphotericin B NBD-labeled lipid Red edge excitation shift Metal cation Fluorescence polarization 
Ricin-B-lectin enhances microsporidia Nosema bombycis infection in BmN cells from silkworm Bombyx mori被引量:8
《Acta Biochimica et Biophysica Sinica》2016年第11期1050-1057,共8页Han Liu Mingqian Li Shunfeng Cai Xinyi He Yongqi Shao Xingmeng Lu 
This work was supported by the grants from the Modern Agricultural Industrial Technology System (No. CARS-22-ZJ0202), Zhejiang Sericultural Sci-Tech Innovation Team (No. 2011R50028), and the National Natural Science Foundation of China (No. 31302033).
Nosema bombycis is an obligate intracellular parasitic fungus that utilizes a distinctive mechanism to infect Bombyx mori. Spore germination can be used for host cell invasion; however, the detailed mechanism remains ...
关键词:MICROSPORIDIA Nosema bombycis invasion ricin-B lectin adhesion 
过表达一个疣粒野生稻的Ricin_B凝集素基因OmR40c1增强水稻耐盐性
《中国水稻科学》2016年第4期335-344,共10页陈贤 董岩 周洁 王栩鸣 严成其 陈剑平 
国家基础研究计划资助项目(2014CB1603090);国家863计划资助项目(2014AA0A603-15);浙江省自然科学基金资助项目(LZ14C140001,LZ2013C1109)
盐胁迫是影响盐/碱稻区水稻产量的主要逆境因素。研究耐盐相关基因,对于培育水稻抗逆品种具有重要意义。OmR40c1是从疣粒野生稻(Oryza meyeriana)中分离获得cDNA序列,与已报道的受脱落酸与盐诱导的OsR40c1的CDS序列完全相同,但在5′端UT...
关键词:疣粒野生稻 OmR40c1 转基因 耐盐性 
深海热液区管状蠕虫Ridgeia piscesae中Ricin B-lectin型结构域基因的克隆与表达
《应用海洋学学报》2014年第4期525-530,共6页徐海鹏 阮灵伟 崔治中 
国际海底区域研究开发”十一五“课题资助项目(DYXM-115-02-2-16)
作为一种重要的模式识别因子,凝集素在多个领域中均有着广泛的应用价值,因此,开发和利用新型凝集素将具有重要意义.本研究以生活在深海热液区极端环境条件下的管状蠕虫Ridgeia piscesae为材料,首次从管状蠕虫中克隆获得Ricin B-lectin基...
关键词:海洋生物学 凝集素 RICIN B-lectin结构域 管状蠕虫Ridgeia piscesae 克隆表达 
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