FUCOSYLATION

作品数：11被引量：26H指数：3
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相关领域：医药卫生生物学更多>>
相关作者：蔡超凡飞高蕾于广利张萍更多>>
相关机构：大连医科大学中国海洋大学更多>>
相关期刊：《Open Journal of Gastroenterology》《Research》《World Journal of Gastroenterology》《Phenomics》更多>>
相关基金：国家自然科学基金更多>>
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Oxytocin Alleviates Colitis and Colitis-Associated Colorectal Tumorigenesis via Noncanonical Fucosylation
《Research》2025年第1期593-605,共13页Xia Wang Dawei Chen Mengnan Guo Yao Ning Mingze Geng Jing Guo Jiahui Gao Dong Zhao Yupeng Zhang Qianpeng Li Lixiang Li Shiyang Li Yanqing Li Xiaoran Xie Xiuli Zuo Jingxin Li 
supported by the following grants:National Natural Science Foundation of China(82070551,82270570,32271172,and 82200584);China Postdoctoral Science Foundation(2022M721963);Taishan Scholars Program of Shandong Province,and the Natural Science Foundation of Shandong Province(ZR2021LSWO12).
Colon cancer is increasing worldwide and is commonly regarded as hormone independent,yet recent reports have implicated sex hormones in its development.Nevertheless,the role of hormones from the hypothalamus-hypophysi...
关键词：sex hormones colon cancer FUCOSYLATION Colorectal Cancer generated mice OXYTOCIN COLITIS 
Fut2 Deficiency Promotes Intestinal Stem Cell Aging by Damaging Mitochondrial Functions via Down-Regulatingα1,2-Fucosylation of Asah2 and Npc1
《Research》2024年第4期545-561,共17页Caihan Duan Zhe Wang Junhao Wu Chen Tan Feifei Fang Wei Qian Chaoqun Han Xiaohua Hou 
supported by the National Natural Science Foundation of China(grant nos.92268108,82170570,and 81974062).
Fut2-mediatedα1,2-fucosylation is important for gut homeostasis,including the intestinal stem cell(ISC).The stemness of ISC declines with age,and aging-associated ISC dysfunction is closely related to many age-relate...
关键词：IMPAIRED AGING ELEVATED 
α2,3-Sialylation with Fucosylation Associated with More Severe Anti-MDA5 Positive Dermatomyositis Induced by Rapidly Progressive Interstitial Lung Disease
《Phenomics》2023年第5期457-468,共12页Rongrong Zhang Li Guo Jichen Sha Shuwai Chang Jiangfeng Zhao Kaiwen Wang Jiucun Wang Jianxin Gu Jing Liu Shifang Ren 
supported by grants from The National Key R&D Program of China(2022YFC3400803);the National Natural Science Foundation of China(32071276);Greater Bay Area Institute of Precision Medicine(IPM2021C005);National Postdoctoral Program for Innovative Talents(BX20190076).
Dermatomyositis(DM)is a heterogeneous autoimmune disease associated with numerous myositis specific antibodies(MSAs)in which DM with anti-melanoma differentiation-associated gene 5-positive(MDA5+DM)is a unique subtype...
关键词：DERMATOMYOSITIS Anti-melanoma differentiation-associated gene 5-positive Interstitial lung disease GLYCOSYLATION Matrix assisted laser desorption/ionization time of flight mass spectrometry 
Core fucosylation and its roles in gastrointestinal glycoimmunology被引量：1
《World Journal of Gastrointestinal Oncology》2023年第7期1119-1134,共16页Nian-Zhu Zhang Li-Fen Zhao Qian Zhang Hui Fang Wan-Li Song Wen-Zhe Li Yu-Song Ge Peng Gao 
Supported by the National Natural Science Foundation of China,No.32171279;Natural Science Foundation of Liaoning Province,No.2022-BS-254,and No.2022-MS-317;the Project of Dalian Medical Science Research,No.2012026.
Glycosylation is a common post-translational modification in eukaryotic cells.It is involved in the production of many biologically active glycoproteins and the regulation of protein structure and function.Core fucosy...
关键词：Fucosyltransferase 8 Core fucosylation Glycoimmunology Gastrointestinal tumor immunology T cell signal pathway 
Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review被引量：4
《World Journal of Gastroenterology》2019年第23期2947-2960,共14页Pamela A Norton Anand S Mehta 
BACKGROUND Changes in N-linked glycosylation have been observed in the circulation of individuals with hepatocellular carcinoma. In particular, an elevation in the level of core fucosylation has been observed. However...
关键词：Liver cancer N-LINKED GLYCOSYLATION FUCOSE GUANOSINE DIPHOSPHATE FUCOSE Hepatocellular carcinoma 
A vital sugar code for ricin toxicity被引量：2
《Cell Research》2017年第11期1351-1364,共14页Jasmin Taubenschmld Johannes Stadlmann Markus Jost Tove Irene Klok.k Cory D Rillahan Andreas Leibbrandt Karl Mechtler James C Paulson Julian Jude Johannes Zuber Kirsten Sandvig Ulrich Elling Thorsten Marquardt Christian Thiel Christian Koerner Josef M Penninger 
Ricin is one of the most feared bioweapons in the world due to its extreme toxicity and easy access. Since no anti- dote exists, it is of paramount importance to identify the pathways underlying ricin toxicity. Here, ...
关键词：RICIN TOXIN FUCOSYLATION SIALYLATION Lewis X intracellular trafficking 
Blocking Posttranslational Core Fucosylation Ameliorates Rat Peritoneal Mesothelial Cell Epithelial-Mesenchymal Transition被引量：4
《Chinese Medical Journal》2017年第18期2147-2155,共9页Long-Kai Li Nan Wang Wei-Dong Wang Xiang-Ning Du Xin-Yu Wen Ling-Yu Wang Yi-Yao Deng Da-Peng Wang Hong-Li Lin 
This work was supported by a grant from the National Natural Science Foundation of China （No. 81530021）.
Background：Core fucosylation （CF）,catalyzed by α-1,6 fucosyltransferase （Fut8） in mammals,plays an important role in pathological processes through posttranslational modification of key signaling receptor protei...
关键词：α-1 6 Fucosyltransferase： Core Fucosylation： Epithelial Mesenchymal Transition Peritoneal Fibrosis 
Fucosylation is a common glycosylation type in pancreatic cancer stem cell-like phenotypes
《World Journal of Gastroenterology》2015年第13期3876-3887,共12页Naoko Terao Shinji Takamatsu Tomomi Minehira Tomoaki Sobajima Kotarosumitomo Nakayama Yoshihiro Kamada Eiji Miyoshi 
Grant-in-Aid for Scientific Research(A;No.21249038)from the Japan Society for the Promotion of Science;partially supported as a research program of the Project for Development of Innovative Research on Cancer Therapeutics(P-Direct),Ministry of Education,Culture,Sports,Science and Technology of Japan
AIM: To evaluate/isolate cancer stem cells(CSCs) from tissue or cell lines according to various definitions and cell surface markers. METHODS: Lectin microarray analysis was conducted on CSC-like fractions of the huma...
关键词：ANTI-CANCER DRUG resistance Cancer stem cells Fuco 
Glycoprotein fucosylation is increased in seminal plasma of subfertile men
《Asian Journal of Andrology》2015年第2期274-280,I0010,共8页Beata Olejnik Ewa M Kratz Mariusz Zimmer Mirostawa Ferens-Sieczkowska 
Fucose, the monosaccharide frequent in N- and O-glycans, is a part of Lewis-type antigens that are known to mediate direct sperm binding to the zona pellucida. Such interaction was found to be inhibited in vitro by fu...
关键词：FUCOSE GLYCOSYLATION INFERTILITY seminal plasma 
Alteration of liver N-glycome in patients with hepatocellular carcinoma被引量：2
《Open Journal of Gastroenterology》2012年第1期1-8,共8页Ling Wang Valerie Vanhooren Sylviane Dewaele Xue-En Liu Claude Libert Feng-Min Lu Hui Zhuang Cuiying Chitty Chen 
Purpose: Alteration of liver function during pro- gression of hepatocellular carcinoma (HCC) and cirrhosis affects the serum glycoprotein pattern. In this study, the changes in the N-glycome in liver tis- sue from pat...
关键词：N-Glycome DSA-FACE FUCOSYLATION HCC CIRRHOSIS 
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