GUANOSINE

作品数：53被引量：106H指数：6
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相关领域：医药卫生更多>>
相关作者：余奕李晓东杨文修赵玉英梁鸿更多>>
相关机构：北京大学南开大学中国药科大学香港科技大学更多>>
相关期刊：《International Journal of Ophthalmology(English edition)》《Chinese Medical Journal》《Signal Transduction and Targeted Therapy》《Neural Regeneration Research》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划上海市自然科学基金更多>>
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Photochemical reaction mechanism of benzophenone protected guanosine at N7 position
《Chinese Chemical Letters》2025年第3期311-315,共5页Yan Guo Hongtao Bian Le Yu Jiani Ma Yu Fang 
sponsored by grants from the National Natural Science Foundation of China(Nos.22322301,22303046);the Shaanxi Science Fund for Distinguished Young Scholars(No.2021JC-38);the Fundamental Research Funds for the Central Universities(Nos.GK202207001,GK202304008);the Shaanxi Province Postdoctoral Science Foundation(No.2023BSHEDZZ187).
Aryl ketones as photolabile protecting group(PPG)to modify purine imines is a novel nucleic acid protection strategy.Especially,photoprotection of N7-guanosine is the first reported photoprotected nucleoside that can ...
关键词：Excited state Photolabile protecting group Time-resolved spectroscopy Transient absorption DFT calculation 
On the Impairment of Stress-Induced Changes in Triglyceride Levels via a Sub-Toxic Dose of Unmethylated Cytidine Phosphate Guanosine Oligodinucleotide (a Toll-Like Receptor 9 Ligand)
《Journal of Biosciences and Medicines》2024年第9期95-112,共18页Reiko Seki Kazuhisa Nishizawa 
Changes in lipid metabolism have been implicated in protection against infectious diseases. In the first experiment of this study, we measured clinical lipid parameters in a murine model where the unmethylated cytidin...
关键词：Toll-Like Receptor 9 Cytidine Phosphate Guanosine Oligodinucleotide Scavenger Receptor B1 TRIGLYCERIDE Hepatic Inflammation 
Recognition and chirality sensing of guanosine-containing nucleotides by an achiral tetraphenylethene-based octacationic cage in water
《Chinese Chemical Letters》2024年第1期267-270,共4页Honghong Duan Ting Yang Qingfang Li Fan Cao Pingxia Wang Liping Cao 
the National Natural Science Foundation of China(Nos.22122108 and 21971208);the Natural Science Basic Research Plan for Distinguished Young Scholars in Shaanxi Province of China(No.2021JC-37);the Fok Ying Tong Education Foundation(No.171010).
The development of molecular probes or systems with the ability of multiple orthogonal responses is an effective approach to precisely detect biomolecules with similar chemical structures.Herein,we report the synthesi...
关键词：Host-guest recognition Chirality sensing Tetraphenylethene Achiral cage Nucleotide 
Supramolecular G-quadruplex hydrogels:Bridging fabrication to biomedical application
《Journal of Materials Science & Technology》2023年第24期238-252,共15页Yuanfeng Li Junjie Chi Pingwei Xu Xing Dong Anh-Tuan Le Keqing Shi Yong Liu Jian Xiao 
financially supported by the National Natural Science Foundation of China(Grant Nos.52203184,52003184);the Startup Fund of Wenzhou Institute,University of Chinese Academy of Sciences(Grant No.WIUCASQD2021022).
G-quadruplex hydrogel is a class of self-assembled supramolecular hydrogel formed by guanine derivatives.As a biomimetic hydrogel,G-quadruplex hydrogels demonstrate wide biomedical applications,such as drug delivery,t...
关键词：GUANOSINE DNA hydrogel Self-assembly Drug delivery Tissue engineering 
All-small-molecule supramolecular hydrogels assembled from guanosine 5′-monophosphate disodium salt and tobramycin for the treatment of bacterial keratitis被引量：3
《Bioactive Materials》2022年第10期293-300,共8页Xuejing Cheng Huiyu Chen Fang Yang Jiaxu Hong Yiyun Cheng Jingjing Hu 
from the Natural Science Foundation of Shanghai(19ZR1415600);the National Natural Science Foundation of China(81970766 and 82171102);the Program for Professor of Special Appointment(Estern Scholar)at Shanghai Institutions of Higher Learning,the Shanghai Innovation Development Program(2020-RGZN-02033);the Shanghai Key Clinical Research Program(SHDC2020CR3052B);the Fundamental Research Funds for the Central Universities.
Bacterial keratitis is the most common corneal infection which may lead to blindness,and seriously threatened the human visual health worldwide.Clinical treatment with antibiotic eye drops formulation usually falls in...
关键词：HYDROGEL Supramolecular gel Antibacterial hydrogel AMINOGLYCOSIDE Bacterial keratitis 
Molecular Similarity within Carcinogen and Guanine Cyclic Nucleotide Structures
《Journal of Biosciences and Medicines》2022年第5期86-94,共9页Wynford Robert Williams 
Tumor promoters, apoptosis and autophagy modulators, chemotherapy drugs, and endogenous steroids demonstrate molecular similarity relative to cyclic nucleotide structure. This study explores relative molecular similar...
关键词：ANESTHETICS Cancer CARCINOGENS Guanosine Cyclic Monophosphate Molecular Similarity 
The mechanisms of nucleotide actions in insulin resistance被引量：3
《Journal of Genetics and Genomics》2022年第4期299-307,共9页Kunpeng Liu Xiaogao Jin Xiaoying Zhang Hongkai Lian Jianping Ye 
supported by the starting funds from the Metabolic Disease Research Center,Zhengzhou University Affiliated Zhengzhou Central Hospital and the Center for Advanced Medicine,College of Medicine,Zhengzhou University,Zhengzhou to Jianping Ye。
Insulin resistance contributes to metabolic disorders in obesity and type 2 diabetes.In mechanisms of insulin resistance,the roles of glucose,fatty acids,and amino acids have been extensively documented in literature....
关键词：Insulin resistance NUCLEOTIDE ADENOSINE GUANOSINE URIDINE AMPK Purinergic receptors 
Development of an eco-friendly and fast HPLC method for quantitative analysis of four nucleosides in Cordyceps and related products被引量：2
《Chinese Journal of Natural Medicines》2021年第12期954-960,共7页QIAN Zheng-Ming WU Zi HUANG Qi WANG Chuan-Xi TAN Guo-Yin LI Wen-Jia SUN Wan-Yang LV Gen-Pin GAO Hao 
supported by the National Natural Science Foundation of China (Nos.81925037, 82073976, and 31700013);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (No.2017BT01Y036);Guangdong Natural Science Funds for Distinguished Young Scholar(No.2021B1515020065);the Young Elite Scientists Sponsorship Program by the China Association of Chinese Medicine (No.QNRC2-B06);the Dongguan Academician Workstation Project (No.DGYSZ-2018-03)。
An eco-friendly and fast HPLC method was developed for the determination of adenosine, inosine, guanosine and uridine in Cordyceps and related products(fermented mycelia of Hirsutella sinensis and Paecilomyces hepiali...
关键词：ADENOSINE INOSINE GUANOSINE URIDINE CORDYCEPS 
Cyclic Nucleotide Structural Differentiation of Compounds Modulating Apoptosis and Drug Resistance被引量：2
《Journal of Biosciences and Medicines》2021年第8期10-28,共19页Wynford Robert Williams 
Carcinogenesis is associated with malfunction in the cGMP-mediated regulation of cytosolic Ca2+ and reactive oxygen species. Chemotherapy resistant cancer cells are re-sensitised to apoptosis by the action ...
关键词：Cancer CHEMOTHERAPY Guanosine Cyclic Monophosphate Molecular Similarity Multidrug Resistance 
Guanosine-5'-triphosphate cyclohydrolase 1 regulated long noncoding RNAs are potential targets for microglial activation in neuropathic pain被引量：4
《Neural Regeneration Research》2021年第3期596-600,共5页Yan-Hu Liang Guo-Wu Chen Xue-Song Li Shu Jia Chun-Yang Meng 
supported by the National Natural Science Foundation of China,Nos.81572205 and 81974345(both to CYM)。
Several studies have confirmed that microglia are involved in neuropathic pain.Inhibition of guanosine-5′-triphosphate cyclohydrolase 1(GTPCH1)can reduce the inflammation of microglia.However,the precise mechanism by...
关键词：cells factors INFLAMMATION MICROGLIA PAIN pathway protein RNA 
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