NUCLEOTIDE

作品数：321被引量：693H指数：11
导出分析报告
相关领域：医药卫生生物学更多>>
相关作者：张罗唐雪明朱连龙张小波吴潇更多>>
相关机构：首都医科大学北京大学浙江大学南京医科大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划上海市青年科技启明星计划更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Pangenome analysis of Rummeliibacillus sp.strains reveals their unexpected diversity and potential for industrial application
《微生物学报》2025年第2期781-795,共15页ZOU Wei YANG Lingling LIU Chaojie ZHENG Jia ZHANG Kaizheng QIAO Zongwei 
中国轻工业浓香型白酒固态发酵重点实验室开放基金(2021JJ017)。
[Objective]Rummeliibacillus,a genus encompassing three known species,R.stabekisii,R.pycnus,and R.suwonensis,has a wide range of potential applications in biodegradation,probiotics,animal feed,and production of arginin...
关键词：average nucleotide identity Bacterial pan-genome analysis(BPGA) genomic islands pangenome Rummeliibacillus 
Nucleotide Relative Molecular Similarity within Anti-Emetic/Pro-Kinetic Drug Structures
《Journal of Biosciences and Medicines》2025年第1期215-229,共15页Wynford Robert Williams 
The physiology of the central and enteric nervous systems and gastric muscle contributes to the complexities encountered in the research and clinical management of gastroparesis. A wide range of prescription drugs tar...
关键词：GASTROPARESIS Adenine Nucleotides Neurotransmitter Agents Molecular Structure 
Population-wide DNA methylation polymorphisms at single-nucleotide resolution in 207 cotton accessions reveal epigenomic contributions to complex traits
《Cell Research》2024年第12期859-872,共14页Ting Zhao Xueying Guan Yan Hu Ziqian Zhang Han Yang Xiaowen Shi Jin Han Huan Mei Luyao Wang Lei Shao Hongyu Wu Qianqian Chen Yongyan Zhao Jiaying Pan Yupeng Hao Zeyu Dong Xuan Long Qian Deng Shengjun Zhao Mengke Zhang Yumeng Zhu Xiaowei Ma Zequan Chen Yayuan Deng Zhanfeng Si Xin Li Tianzhen Zhang Fei Gu Xiaofeng Gu Lei Fang 
This work was financially supported in part by grants from the Biological Breeding-Major Projects(2023ZD04076);the National Natural Science Foundation of China(32341024);Fundamental Research Funds for the Central Universities(226-2022-00100;226-2024-00205);the Alibaba-Zhejiang University Joint Research Institute of Frontier Technologies.
DNA methylation plays multiple regulatory roles in crop development.However,the relationships of methylation polymorphisms with genetic polymorphisms,gene expression,and phenotypic variation in natural crop population...
关键词：breeding alone COTTON 
A-to-G/C/T and C-to-T/G/A dual-function base editor for creating multi-nucleotide variants
《Journal of Genetics and Genomics》2024年第12期1494-1504,共11页Bingxiu Ma Han Wu Shixue Gou Meng Lian Cong Xia Kaiming Yang Long Jin Junyuan Liu Yunlin Wu Yahai Shu Haizhao Yan Zhanjun Li Liangxue Lai Yong Fan 
supported by the National Key Research and Development Program of China(2021YFC2700904,2021YFF0702601,2021YFA0805300);the National Natural Science Foundation of China(82071723,82100482,82101733);Guangdong Basic and Applied Basic Research Foundation(2021B1515020069);Guangzhou Science and Technology Planning Project(2023A03J0377);Research Unit of Generation of Large Animal Disease Models,Chinese Academy of Medical Sciences(2019-I2M-5-025)。
Multi-nucleotide variants(MNVs)are critical genetic variants associated with various genetic diseases.However,tools for precisely installing MNVs are limited.In this study,we present the development of a dual-base edi...
关键词：CRISPR Gene editing Dual-base editor A-to-G/C/T and C-to-T/G/A MNV Genetic diseases 
Metformin promotes anti-tumor immunity in STK11 mutant NSCLC through AXIN1-dependent upregulation of multiple nucleotide metabolites
《Oncology Research》2024年第10期1637-1648,共12页ZHIGUO WANG KUNLIN LI CONGHUA LU MINGXIA FENG CAIYU LIN GUOFANG YIN DAN LUO WENYI LIU KAIYU JIN YUANYAO DOU DI WU JIE ZHENG KEJUN ZHANG LI LI XIANMING FAN 
People’s Hospital of Xuyong County-Southwest Medical University Science and Technology Strategic Cooperation Project(2023XYXNYD05);Guangdong Association of Clinical Trials(GACT)/Chinese Thoracic Oncology Group(CTONG)and Guangdong Provincial Key Lab of Translational Medicine in Lung Cancer(2017B030314120);Natural Science Foundation of Chongqing Municipality(CSTB2023NSCQ-MSX0554).
Background:Metformin has pleiotropic effects beyond glucose reduction,including tumor inhibition and immune regulation.It enhanced the anti-tumor effects of programmed cell death protein 1(PD-1)inhibitors in serine/th...
关键词：METFORMIN Serine/threonine kinase 11(STK11) Lung cancer Axis inhibition protein 1(AXIN1) Nucleotide metabolites 
Phylogenetic analyses and antigenic characterization of foot-and-mouth disease virus PanAsia lineage circulating in China between 1999 and 2023
《Virologica Sinica》2024年第5期747-754,共8页Xiangle Zhang Weimin Ma Baohong Liu Chaochao Shen Fan Yang Yamin Yang Lv Lv Jinyan Wu Yongjie Liu Youjun Shang Jianhong Guo Zixiang Zhu Xiangtao Liu Haixue Zheng Jijun He 
supported by grants from the National Key R&D Program of China(2021YFD1800300);the Fundamental Research Funds for the Central Universities,the Fundamental Research Funds for Innovation Team of Gansu Province(23JRRA546);the Key Technologies R&D Program of Gansu Province(23JRRA1515);the Innovation Project for Young Scientist in Lanzhou(2023-QN-75);the Open Competition Program of Top Ten Critical Priorities of Agricultural Science and Technology Innovation for the 14th Five-Year Plan of Guangdong Province(2023SDZG02);the Project of National Center of Technology Innovation for Pigs(NCTIP-XD/C03);the GACC project(2024HK068);the Basic Research Fund of LVRI in CAAS(LVRI-1610312022006);the Earmarked Fund for CARS-35 and CARS-39-13.
Foot-and-mouth disease(FMD)is one of the most important transboundary animal diseases caused by foot-andmouth disease virus(FMDV),leading to significant economic losses worldwide.Thefirst report of PanAsia lineage of FM...
关键词：Foot-and-mouth disease virus(FMDV) EPIDEMIOLOGY Nucleotide homology Prevention VACCINE 
An improved plant prime editor for efficient generation of multiple-nucleotide variations and structural variations in rice被引量：1
《Plant Communications》2024年第9期21-24,共4页Zhaohui Zhong Tingting Fan Yao He Shishi Liu Xuelian Zheng Yang Xu Jingqi Ren Hua Yuan Zhengyan Xu Yong Zhang 
supported by the STI 2030-Major Projects(2023ZD04074)to Y.Z.;the National Natural Science Foundation of China(award nos.32301245 and 32072045)to Z.Z.and X.Z.
Dear Editor,The ability to manipulate single-nucleotide variations(SNVs),multiple-nucleotide variations(MNVs),and structural variations(SVs)in rice genomes is crucial for studying gene function and improving agricultu...
关键词：STRUCTURAL EDITOR NUCLEOTIDE 
Tongqiao Yizhi granule(通窍益智颗粒) repress the nuclear factor kappa-b/nucleotide oligomerization domain-like receptors 3/caspase-1 pyroptosis pathway in the hippocampus to counter vascular dementia in rats
《Journal of Traditional Chinese Medicine》2024年第4期680-687,共8页LI Yanjiao HAO Linyao LI Shuangyang LUO Yanqi WANG Juan WANG Raoqiong BAI Xue 
Sichuan Provincial Science and Technology Department Applied Basic Research Project:a Dynamic Contrast Enhanced Magnetic Resonance Imaging-based Study on the Effect of Eind Medicine Kaixuan Method on Blood-brain Barrier Function and Prognosis in Patients with Small to Medium Volume Cerebral Hemorrhage(2020YJ0437);Sichuan Provincial Administration of Traditional Chinese Medicine Science and Technology Special:Study on the Mechanism of Shexiang Huayu Xingnao Granules Reducing Nerve Injury in Cerebral Hemorrhage Model Rats by Regulating Microglia Polarization through Peroxisome Proliferator-activated Receptorγ(2021MS506);Luzhou Basic Application Project:the Mechanism of Tongqiao Yizhi Granules in the Treatment of Vascular Dementia by Regulating Gasdermin D-Mediated Pyroptosis(2020-JYJ-57)。
OBJECTIVE:To explore the mechanism by which Tongqiao Yizhi granule(通窍益智颗粒,TQYZKL)intervenes pyroptosis to treat vascular dementia(VaD)in a rat model.METHODS:The rat model of VaD was established by two-vessel occ...
关键词：NLRP3 RATS KAPPA 
Diabetic cardiomyopathy:Importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis
《World Journal of Diabetes》2024年第8期1659-1662,共4页Lu Cai Yi Tan Md Shahidul Islam Michael Horowitz Kupper A Wintergerst 
Recently,the roles of pyroptosis,a form of cell death induced by activated NODlike receptor protein 3(NLRP3)inflammasome,in the pathogenesis of diabetic cardiomyopathy(DCM)have been extensively investigated.However,mo...
关键词：Diabetic cardiomyopathy Nucleotide oligomerization domain NOD-like receptor protein 3 inflammasome Cardiac cell death PYROPTOSIS 
饲料中添加不同水平的核苷酸对草鱼生长性能的影响
《黑龙江水产》2024年第3期277-280,共4页李绪清 
试验旨在研究饲料中不同水平的核苷酸(Nucleotide)对草鱼(Ctenopharyngodon idella)生长性能的影响,为核苷酸在草鱼养殖生产中的高效应用提供参考。试验选择560尾体重约为10g的健康的草鱼,按照单因素试验设计,将其均分4组,每组5个重复,...
关键词：核苷酸(Nucleotide) 草鱼(Ctenopharyngodon idella) 增重率 饲料系数 特定生长率 
全选清除导出
共33页<12345678910>
检索报告 对象比较 聚类工具 使用帮助 返回顶部