Diabetic cardiomyopathy:Importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis  

作　　者：Lu Cai Yi Tan Md Shahidul Islam Michael Horowitz Kupper A Wintergerst 

机构地区：[1]Pediatric Research Institute,Departments of Pediatrics,Radiation Oncology,Pharmacology and Toxicology,University of Louisville,Wendy Novak Diabetes Institute,Norton Children’s Hospital,Louisville,KY 40202,United States [2]Department of Biochemistry,School of Life Sciences,University of KwaZulu-Natal,Durban 4000,KwaZulu-Natal,South Africa [3]Department of Medicine,University of Adelaide,Adelaide 5005,Australia [4]Pediatric Research Institute,Division of Endocrinology,Department of Pediatrics,Wendy Novak Diabetes Institute,Norton Children’s Hospital,University of Louisville,Louisville,KY 40202,United States

出　　处：《World Journal of Diabetes》2024年第8期1659-1662,共4页世界糖尿病杂志（英文版）（电子版）

摘　　要：Recently,the roles of pyroptosis,a form of cell death induced by activated NODlike receptor protein 3(NLRP3)inflammasome,in the pathogenesis of diabetic cardiomyopathy(DCM)have been extensively investigated.However,most studies have focused mainly on whether diabetes increases the NLRP3 inflammasome and associated pyroptosis in the heart of type 1 or type 2 diabetic rodent models,and whether various medications and natural products prevent the development of DCM,associated with decreased levels of cardiac NLRP3 inflammasome and pyroptosis.The direct link of NLRP3 inflammasome and associated pyroptosis to the pathogenesis of DCM remains unclear based on the limited evidence derived from the available studies,with the approaches of NLRP3 gene silencing or pharmaceutical application of NLRP3 specific inhibitors.We thus emphasize the requirement for more systematic studies that are designed to provide direct evidence to support the link,given that several studies have provided both direct and indirect evidence under specific conditions.This editorial emphasizes that the current investigation should be circumspect in its conclusion,i.e.,not overemphasizing its role in the pathogenesis of DCM with the fact of only significantly increased expression or activation of NLRP3 inflammasome and pyroptosis in the heart of diabetic rodent models.Only clear-cut evidence-based causative roles of NLRP3 inflammasome and pyroptosis in the pathogenesis of DCM can help to develop effective and safe medications for the clinical management of DCM,targeting these biomarkers.

关 键 词：Diabetic cardiomyopathy Nucleotide oligomerization domain NOD-like receptor protein 3 inflammasome Cardiac cell death PYROPTOSIS 

分 类 号：R587.1[医药卫生—内分泌] R542.2[医药卫生—内科学]