supported by STI2030-Major Projects,No.2021ZD 0201801(to JG);Shanxi Province Basic Research Program,No.20210302123429(to QS).
In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial cells.However,the functional role of GGT5 in the development of A...
This study aimed at delineating the shoreline by using the Digital Shoreline Analysis System(DSAS 5.0) tool and detected the changes of land use/land cover(LULC) by Google Earth Engine(GEE) platform. The shoreline is ...
Sichuan Provincial Science and Technology Department Applied Basic Research Project:a Dynamic Contrast Enhanced Magnetic Resonance Imaging-based Study on the Effect of Eind Medicine Kaixuan Method on Blood-brain Barrier Function and Prognosis in Patients with Small to Medium Volume Cerebral Hemorrhage(2020YJ0437);Sichuan Provincial Administration of Traditional Chinese Medicine Science and Technology Special:Study on the Mechanism of Shexiang Huayu Xingnao Granules Reducing Nerve Injury in Cerebral Hemorrhage Model Rats by Regulating Microglia Polarization through Peroxisome Proliferator-activated Receptorγ(2021MS506);Luzhou Basic Application Project:the Mechanism of Tongqiao Yizhi Granules in the Treatment of Vascular Dementia by Regulating Gasdermin D-Mediated Pyroptosis(2020-JYJ-57)。
OBJECTIVE:To explore the mechanism by which Tongqiao Yizhi granule(通窍益智颗粒,TQYZKL)intervenes pyroptosis to treat vascular dementia(VaD)in a rat model.METHODS:The rat model of VaD was established by two-vessel occ...