Cyclic Nucleotide Structural Differentiation of Compounds Modulating Apoptosis and Drug Resistance  

作　　者：Wynford Robert Williams Wynford Robert Williams(Faculty of Life Sciences & Education, University of South Wales, Cardiff, UK)

机构地区：[1]Faculty of Life Sciences & Education, University of South Wales, Cardiff, UK

出　　处：《Journal of Biosciences and Medicines》2021年第8期10-28,共19页生物科学与医学（英文）

摘　　要：Carcinogenesis is associated with malfunction in the cGMP-mediated regulation of cytosolic Ca²⁺ and reactive oxygen species. Chemotherapy resistant cancer cells are re-sensitised to apoptosis by the action of a substantial number of natural compounds on cell membrane multidrug resistant proteins. Chemical structures of pro-apoptotic and anti-apoptotic compounds demonstrate relative molecular similarity to cGMP. This study uses a computational chemistry program to investigate molecular similarity within cGMP and chemo-preventative structures. Chemotherapeutic drugs and resistance modulators provide multiple fits to a nucleotide template that differ in their relationship to the cyclised ring of cGMP. The alternative fits of drug and modulator structures may relate to the development and unblocking of apoptosis and drug resistance.Carcinogenesis is associated with malfunction in the cGMP-mediated regulation of cytosolic Ca²⁺ and reactive oxygen species. Chemotherapy resistant cancer cells are re-sensitised to apoptosis by the action of a substantial number of natural compounds on cell membrane multidrug resistant proteins. Chemical structures of pro-apoptotic and anti-apoptotic compounds demonstrate relative molecular similarity to cGMP. This study uses a computational chemistry program to investigate molecular similarity within cGMP and chemo-preventative structures. Chemotherapeutic drugs and resistance modulators provide multiple fits to a nucleotide template that differ in their relationship to the cyclised ring of cGMP. The alternative fits of drug and modulator structures may relate to the development and unblocking of apoptosis and drug resistance.

关 键 词：Cancer CHEMOTHERAPY Guanosine Cyclic Monophosphate Molecular Similarity Multidrug Resistance 

分 类 号：R73[医药卫生—肿瘤]