AMINOGLYCOSIDE

作品数：36被引量：105H指数：6
导出分析报告
相关领域：医药卫生更多>>
相关作者：李中军孟祥豹陈桂辉陈颖潘攀更多>>
相关机构：北京大学上海中医药大学江西医学院第一附属医院北京协和医学院更多>>
相关期刊：《Journal of Microbiology and Immunology》《Bioactive Materials》《Journal of Chinese Pharmaceutical Sciences》《武警医学》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划上海市自然科学基金中国博士后科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss被引量：1
《Neural Regeneration Research》2025年第10期3025-3039,共15页Jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin 
supported by the National Natural Science Foundation of China,Nos.81800919(to YX),82171140(to PW);the International Cooperation and Exchange of the National Natural Science Foundation of China,Nos.82020108008(to HS),81720108010(to SY).
Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial spectrum.However,their use leads to irreversible hearing damage by causing apoptosis of hair cells as ...
关键词：DEGENERATION hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome OTOTOXICITY pyroptosis sensorineural hearing loss spiral ganglion neuron 
Glycodiversification of gentamicins through in vivo glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity
《Acta Pharmaceutica Sinica B》2024年第9期4149-4163,共15页Xinyun Jian Cheng Wang Shijuan Wu Guo Sun Chuan Huang Chengbing Qiu Yuanzheng Liu Peter FLeadlay Dong Liu Zixin Deng Fuling Zhou Yuhui Sun 
the National Key R&D Program of China(2018YFA0903200);the Funds for International Cooperation and Exchange of the National Natural Science Foundation of China(31920103001).
Aminoglycosides(AGs)are a class of antibiotics with a broad spectrum of activity.However,their use is limited by safety concerns associated with nephrotoxicity and ototoxicity,as well as drug resistance.To address the...
关键词：Antibiotic Aminoglycoside biosynthesis Biosynthetic engineering OTOTOXICITY 
Sensorineural Hearing Loss in Multidrug-Resistant Tuberculosis Patients in Kinshasa (Democratic Republic of Congo): Prospective Cohort Study of Therapeutic Regimen with Aminoglycoside versus Bedaquiline
《Journal of Tuberculosis Research》2023年第3期109-119,共11页Mireille A. Mpwate Eddy M. Mbambu Christian N. Matanda Gabriel M. Lema Michel K. Kaswa Murielle L. Aloni Nicole M. Anshambi Fabrice M. Matuta Luc L. Lukasu Dominique M. Mupepe Serge K. Mpwate Pierre Z. Akilimali Zacharie M. Kashongwe Richard N. Matanda 
Context: Multidrug-resistant tuberculosis (MDR-TB) remains a major public health problem in developing countries such as the Democratic Republic of Congo (DRC), which continues to face the emergence of MDR-TB cases. B...
关键词：Multidrug-Resistant Tuberculosis AMINOGLYCOSIDES Bedaquiline Hearing Loss 
The prevalence and distribution of aminoglycoside resistance genes
《Biosafety and Health》2023年第1期14-20,共7页Yuan Zhang Ning Zhang Mengyu Wang Ming Luo Yao Peng Zhenpeng Li Jialiang Xu Meiling Ou Biao Kan Xu Li Xin Lu 
the National Key Research and Development Program of China(2020YFE0205700,2022YFC2303900);the major projects of the National Natural Science Foundation of China(22193064);the Research Foundation for Youth Scholars of Beijing Technology and Business University(19008022271);the National Science and Technology Major Project(2018ZX10714002);the Science Foundation(2022SKLID303)of the State Key Laboratory of Infectious Disease Prevention and Control,China.
Choosing the appropriate antibiotics to treat bacterial infections has grown more challenging as a result of the emergence of antibiotic-resistant bacteria.Aminoglycosides,as broad-spectrum antibiotics,are increasingl...
关键词：AMINOGLYCOSIDE Aminoglycoside resistance Aminoglycoside resistance gene Aminoglycoside modifying enzyme 16S rRNA methylation enzyme 
Design,synthesis,and bioassay of 5-epi-aminoglycosides
《Chinese Journal of Natural Medicines》2022年第11期854-862,共9页YAN Ribai NIU Youhong LIU Yuheng DENG Junfeng YE Xinshan 
supported by the National Natural Science Foundation of China(No.21877006).
For the purpose of seeking new antibiotics,researchers usually modify the already-existing ones.However,this strategy has been extensively used and is close to its limits,especially in the case of aminoglycosides,and ...
关键词：Antibiotic AMINOGLYCOSIDE A Site Structure-Activity Relationship 
All-small-molecule supramolecular hydrogels assembled from guanosine 5′-monophosphate disodium salt and tobramycin for the treatment of bacterial keratitis被引量：3
《Bioactive Materials》2022年第10期293-300,共8页Xuejing Cheng Huiyu Chen Fang Yang Jiaxu Hong Yiyun Cheng Jingjing Hu 
from the Natural Science Foundation of Shanghai(19ZR1415600);the National Natural Science Foundation of China(81970766 and 82171102);the Program for Professor of Special Appointment(Estern Scholar)at Shanghai Institutions of Higher Learning,the Shanghai Innovation Development Program(2020-RGZN-02033);the Shanghai Key Clinical Research Program(SHDC2020CR3052B);the Fundamental Research Funds for the Central Universities.
Bacterial keratitis is the most common corneal infection which may lead to blindness,and seriously threatened the human visual health worldwide.Clinical treatment with antibiotic eye drops formulation usually falls in...
关键词：HYDROGEL Supramolecular gel Antibacterial hydrogel AMINOGLYCOSIDE Bacterial keratitis 
Mechanistic Study of Oxidoreductase AprQ Involved in Biosynthesis of Aminoglycoside Antibiotic Apramycin
《Chinese Journal of Chemistry》2021年第7期1923-1926,共4页Jinxiu Wang Suze Ma Wei Ding Tuo Chen Qi Zhang 
This work is supported in part by grants from the National Key Research and Development Program(Nos.2018Y F A0900402 and 2016Y F A0501302);from the National Natural Science Foundation of China(Nos.21822703 and 21921003);from the MOST Inter-Government International Science and Technology Innovation Cooperation project(No.2019YFE0121100).
Main observation and conclusion The aminoglycoside antibiotic apramycin contains a unique bicyclic octose moiety,and biosynthesis of this moiety involves an oxidoreductase AprQ.Unlike other known“Q”series proteins i...
关键词：Biosynthesis FLAVIN FLAVOPROTEIN OXIDASE Enzyme mechanism 
Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin被引量：12
《Acta Pharmacologica Sinica》2020年第6期866-878,共13页Lan Yao Jing-wei Zhang Bin Chen Ming-min Cai Dong Feng Qi-zhi Wang Xin-yu Wang Jian-guo Sun Yi-wen Zheng Guang-ji Wang Fang Zhou 
This work was supported by the National Natural Science Foundation of China(81573496,81773989,81530098,and 81573494);the China"Creation of New Drugs"Key Technology Projects(2015ZX09501001,2017ZX09304021);the National Science and Technology Major Project of China(2019ZX09721001-006-005);the International Science and Technology Cooperation Program of China(2017YFE0109600);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.81421005);the Natural Science Foundation of Jiangsu Province(No.BK20160076);the six talent peaks project in Jiangsu Province(YY-060);and the"Double First-Class"University project(CPU2018GF01).
Etimicin(ETM),a fourth-generation aminoglycosides(AGs),is now widely clinically used in China due to its high efficacy and low toxicity.However,the mechanisms underlying its low nephrotoxicity and ototoxicity remain u...
关键词：AMINOGLYCOSIDE ETIMICIN gentamicin AMIKACIN NEPHROTOXICITY OTOTOXICITY pharmacokinetics mitochondria 
Characteristics of two transferable aminoglycoside resistance plasmids in Escherichia coli isolated from pig and chicken manure
《Frontiers of Environmental Science & Engineering》2019年第3期99-113,共15页Chengjun Pu Xiaoyan Gong Ying Sun 
Plasmid-mediated antibiotic resistance genes (ARGs) have recently become a more prominent concern in the global environment. However, the prevalence of aminoglycoside resistance plasmids in the livestock industry is u...
关键词：ESCHERICHIA COLI CHARACTERISTICS AMINOGLYCOSIDE resistance plasmids Transfer PERSISTENCE 
Mitochondrial DNA mutations associated with aminoglycoside induced ototoxicity被引量：10
《Journal of Otology》2017年第1期1-8,共8页Zewen Gao Ye Chen Min-Xin Guan 
supported by the project from National Basic Research Priorities Program of China (2014CB541702);National Natural Science Foundation of China (31671305)
Aminoglycosides(Am An) are widely used for their great efficiency against gram-negative bacterial infections. However, they can also induce ototoxic hearing loss, which has affected millions of people around the world...
关键词：AMINOGLYCOSIDES OTOTOXICITY Genetic SUSCEPTIBILITY MITOCHONDRIAL DNA MUTATIONS 
全选清除导出
共4页<1234>
检索报告 对象比较 聚类工具 使用帮助 返回顶部