AMINOGLYCOSIDES

作品数:25被引量:42H指数:3
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相关领域:医药卫生更多>>
相关作者:叶建中张亚培张晓蕾马传玲周铁丽更多>>
相关机构:温州医科大学北京大学泸州医学院附属医院泸州医学院更多>>
相关期刊:《Advances in Infectious Diseases》《Surgical Science》《Journal of Intensive Medicine》《Chinese Medical Journal》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划江苏省自然科学基金四川省教育厅青年基金更多>>
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Nebulized aminoglycosides for ventilator-associated pneumonia:Methodological considerations and lessons from experimental studies
《Journal of Intensive Medicine》2025年第1期12-22,共11页Jean-Jacques Rouby Jing Xia Jayesh Dhanani Gianluigi Li Bassi Antoine Monsel Antoni Torres on behalf of the European Investigators Network for Nebulized Antibiotics in Ventilator-associated Pneumonia(ENAVAP) 
Aminoglycosides are concentration-dependent antibiotics exerting a bactericidal effect when concentrations at the site of infection are equal to or greater than 5 times the minimum inhibitory concentrations(MIC).When ...
关键词:AMINOGLYCOSIDES Ventilator-associated pneumonia Nebulized amikacin Nebulized tobramycin Lung microdialysis Experimental intensive care unit 
Neo I represents a group of transcriptional repressors regulating the biosynthesis of multiple aminoglycosides
《Science China(Life Sciences)》2024年第12期2761-2770,共10页Yue Li Xiangxi Meng Dong Li Xiulei Xia Jihui Zhang Yihua Chen Huarong Tan 
supported by the National Natural Science Foundation of China (32170043,82173720);the National Key Research and Development Program of China (2020YFA0907800)。
In general,the initiation or closure of antibiotic biosynthesis is determined by regulatory proteins,but most of their mechanisms of action remain unknown.The 2-deoxystreptamine-containing aminoglycosides(2-DOS AGs)fo...
关键词:AMINOGLYCOSIDES NEOMYCIN REGULATION Streptomyces fradiae 
Molecular Docking Studies on Streptomycin Antileishmanial Activity
《Open Journal of Physical Chemistry》2024年第2期36-48,共13页Todd A. Young Matthew George Jr. Ayele Gugssa William M. Southerland Yayin Fang Clarence M. Lee 
Resistance to pentavalent antimonial drugs and the lack of vaccines make it urgent to find novel therapeutic options to treat Leishmaniasis, a tropical disease caused by the Leishmania protozoan parasite. The study re...
关键词:LEISHMANIASIS STREPTOMYCIN Amphotericin B Molecular Docking AMINOGLYCOSIDES ANTILEISHMANIAL 
Injury and protection of spiral ganglion neurons
《Chinese Medical Journal》2024年第6期651-656,共6页Beilei Duan Kevin A.Peng Line Wang 
supported by a grant from the Beijing Municipal Commission of Science and Technology(Applied technology research and development project)(No.Z191100007619043).
Cochlear spiral ganglion neurons(SGNs)are bipolar ganglion cells and are the first neurons in the auditory transduction pathway.They transmit complex acoustic information from hair cells to second-order sensory neuron...
关键词:Spiral ganglion INJURY PROTECTION Auditory hair cell Ototoxic drugs AMINOGLYCOSIDES PRESBYCUSIS 
Detection of aac(3)IIc, aac(6)Ib, armA Genes Coding for Escherichia coli Resistance to Aminoglycosides in Burkina Faso
《Advances in Infectious Diseases》2023年第4期574-585,共12页Pamane Djagbare Christelle Nadembega Tani Sagna Abdoul Karim Ouattara Emmanuel Sampo Théodora Zohoncon Moussa Ouedraogo Marius Belemgnegre Dorcas Obiri-Yeboah Jacques Simpore 
Background and Prupose: Antibiotic resistance is a major global health concern. In addition to the existing data on the prevalence of bacterial resistance to antibiotics, there are patchy data on bacterial resistance ...
关键词:E. coli Aminoglycoside Resistance acc(3’)-IIc aac(6’)-Ib ARMA Burkina Faso 
Sensorineural Hearing Loss in Multidrug-Resistant Tuberculosis Patients in Kinshasa (Democratic Republic of Congo): Prospective Cohort Study of Therapeutic Regimen with Aminoglycoside versus Bedaquiline
《Journal of Tuberculosis Research》2023年第3期109-119,共11页Mireille A. Mpwate Eddy M. Mbambu Christian N. Matanda Gabriel M. Lema Michel K. Kaswa Murielle L. Aloni Nicole M. Anshambi Fabrice M. Matuta Luc L. Lukasu Dominique M. Mupepe Serge K. Mpwate Pierre Z. Akilimali Zacharie M. Kashongwe Richard N. Matanda 
Context: Multidrug-resistant tuberculosis (MDR-TB) remains a major public health problem in developing countries such as the Democratic Republic of Congo (DRC), which continues to face the emergence of MDR-TB cases. B...
关键词:Multidrug-Resistant Tuberculosis AMINOGLYCOSIDES Bedaquiline Hearing Loss 
Is fat-free mass-based gentamicin dosing regimen preferable than whole-body weight in neonates?
《Pediatric Investigation》2023年第2期86-94,共9页Kannan Sridharan Muna Al Jufairi Eman Al Ansari Lulwa Alsadah Howra Wasel 
Importance:Body fluid dynamics and renal maturation status vary during the neonatal period.We hypothesized that differences in peak and trough gentamicin concentrations could be expected.Objective:To predict the peak ...
关键词:AMINOGLYCOSIDES Body weight FAT Fat-free mass GENTAMICIN 
Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus,persisters and biofilms被引量:1
《Bioactive Materials》2022年第8期272-289,共18页Shutao Zhang Xinhua Qu Juyang Jiao Haozheng Tang Minqi Wang You Wang Hongtao Yang Weien Yuan Bing Yue 
supported by the National Natural Science Foundation of China(Grant No.82172464,82172453,81972086);National Key Research and Development Project of China(Grant No.2020YFC1107500,2020YFC1107503);The Shanghai Rising-Star Program(21QA1405500);Shanghai“Rising Stars of Medical Talent”Youth Development Program(Youth Medical Talents-Specialist Program)(Grant No.2019-72);“Technology Innovation Action Plan”Key Project of Shanghai Science and Technology Commission(Grant No.19411962800);Shanghai municipal education commission-Gaofeng clinical medicine grant support(Grant No.20161423);NSFC Advancing Targeted Projects(RJTJ-JX-005,RJTJ22-RC-011).
Methicillin-resistant Staphylococcus aureus(MRSA),biofilms,and persisters are three major factors leading to recurrent and recalcitrant implant infections.Although antibiotics are still the primary treatment for chron...
关键词:AMINOGLYCOSIDES FELODIPINE Persisters Methicillin-resistant Staphylococcus aureus Implant infection 
Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear hair cells被引量:1
《Frontiers of Medicine》2022年第4期637-650,共14页Gaogan Jia Huanyu Mao Yanping Zhang Yusu Ni Yan Chen 
supported by the National Key R&D Program of China(No.2017YFA0103900);the National Natural Science Foundation of China(Nos.81771010 and 81570911);the Nature Science Foundation(No.17ZR1404600);from Shanghai Science and Technology Committee.
Oxidative stress plays an important role in the pathogenesis of aminoglycoside-induced hearing loss and represents a promising target for treatment.We tested the potential effect of apigenin,a natural flavonoid with a...
关键词:APIGENIN AMINOGLYCOSIDES OTOTOXICITY oxidative stress Nrf2 signaling pathway 
Safety in Surgery:Evaluation of Safety and Efficiency in Use of Aminoglycosides in Acute Appendicitis
《Surgical Science》2020年第5期99-110,共12页Tadeja Pintar Bojana Beovic 
Background: Aminoglycosides are used as empirical antibiotic treatment of intraabdominal infections which are caused by Gram negative bacteria and for which the treatment of choice is surgery. Aminoglycosides maintain...
关键词:IAI(Intraabdominal Infections) AMINOGLYCOSIDES Acute Appendicitis Safety Use and Efficiency 
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