Aminoglycosides are concentration-dependent antibiotics exerting a bactericidal effect when concentrations at the site of infection are equal to or greater than 5 times the minimum inhibitory concentrations(MIC).When ...
supported by the National Natural Science Foundation of China (32170043,82173720);the National Key Research and Development Program of China (2020YFA0907800)。
In general,the initiation or closure of antibiotic biosynthesis is determined by regulatory proteins,but most of their mechanisms of action remain unknown.The 2-deoxystreptamine-containing aminoglycosides(2-DOS AGs)fo...
Resistance to pentavalent antimonial drugs and the lack of vaccines make it urgent to find novel therapeutic options to treat Leishmaniasis, a tropical disease caused by the Leishmania protozoan parasite. The study re...
supported by a grant from the Beijing Municipal Commission of Science and Technology(Applied technology research and development project)(No.Z191100007619043).
Cochlear spiral ganglion neurons(SGNs)are bipolar ganglion cells and are the first neurons in the auditory transduction pathway.They transmit complex acoustic information from hair cells to second-order sensory neuron...
Background and Prupose: Antibiotic resistance is a major global health concern. In addition to the existing data on the prevalence of bacterial resistance to antibiotics, there are patchy data on bacterial resistance ...
Context: Multidrug-resistant tuberculosis (MDR-TB) remains a major public health problem in developing countries such as the Democratic Republic of Congo (DRC), which continues to face the emergence of MDR-TB cases. B...
Importance:Body fluid dynamics and renal maturation status vary during the neonatal period.We hypothesized that differences in peak and trough gentamicin concentrations could be expected.Objective:To predict the peak ...
supported by the National Natural Science Foundation of China(Grant No.82172464,82172453,81972086);National Key Research and Development Project of China(Grant No.2020YFC1107500,2020YFC1107503);The Shanghai Rising-Star Program(21QA1405500);Shanghai“Rising Stars of Medical Talent”Youth Development Program(Youth Medical Talents-Specialist Program)(Grant No.2019-72);“Technology Innovation Action Plan”Key Project of Shanghai Science and Technology Commission(Grant No.19411962800);Shanghai municipal education commission-Gaofeng clinical medicine grant support(Grant No.20161423);NSFC Advancing Targeted Projects(RJTJ-JX-005,RJTJ22-RC-011).
Methicillin-resistant Staphylococcus aureus(MRSA),biofilms,and persisters are three major factors leading to recurrent and recalcitrant implant infections.Although antibiotics are still the primary treatment for chron...
supported by the National Key R&D Program of China(No.2017YFA0103900);the National Natural Science Foundation of China(Nos.81771010 and 81570911);the Nature Science Foundation(No.17ZR1404600);from Shanghai Science and Technology Committee.
Oxidative stress plays an important role in the pathogenesis of aminoglycoside-induced hearing loss and represents a promising target for treatment.We tested the potential effect of apigenin,a natural flavonoid with a...
Background: Aminoglycosides are used as empirical antibiotic treatment of intraabdominal infections which are caused by Gram negative bacteria and for which the treatment of choice is surgery. Aminoglycosides maintain...