ETIMICIN

作品数：5被引量：19H指数：2
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相关领域：医药卫生更多>>
相关作者：李培忠李忠东王海学张莉蓉马小超更多>>
相关机构：空军总医院军事医学科学院郑州大学中国科学院上海生命科学研究院更多>>
相关期刊：《Acta Pharmacologica Sinica》《Chinese Medical Journal》《Journal of Chinese Pharmaceutical Sciences》更多>>
相关基金：国家自然科学基金更多>>
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Mechanisms and pharmacokinetic/pharmacodynamic profiles underlying the low nephrotoxicity and ototoxicity of etimicin被引量：12
《Acta Pharmacologica Sinica》2020年第6期866-878,共13页Lan Yao Jing-wei Zhang Bin Chen Ming-min Cai Dong Feng Qi-zhi Wang Xin-yu Wang Jian-guo Sun Yi-wen Zheng Guang-ji Wang Fang Zhou 
This work was supported by the National Natural Science Foundation of China(81573496,81773989,81530098,and 81573494);the China"Creation of New Drugs"Key Technology Projects(2015ZX09501001,2017ZX09304021);the National Science and Technology Major Project of China(2019ZX09721001-006-005);the International Science and Technology Cooperation Program of China(2017YFE0109600);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(No.81421005);the Natural Science Foundation of Jiangsu Province(No.BK20160076);the six talent peaks project in Jiangsu Province(YY-060);and the"Double First-Class"University project(CPU2018GF01).
Etimicin(ETM),a fourth-generation aminoglycosides(AGs),is now widely clinically used in China due to its high efficacy and low toxicity.However,the mechanisms underlying its low nephrotoxicity and ototoxicity remain u...
关键词：AMINOGLYCOSIDE ETIMICIN gentamicin AMIKACIN NEPHROTOXICITY OTOTOXICITY pharmacokinetics mitochondria 
Possible Mechanism of Effects of Etimicin and Gentamicin on Intracellular Calcium Homeostasis
《Journal of Chinese Pharmaceutical Sciences》2005年第2期131-134,共4页李忠东 王建昌 李培忠 
Aim Intracellular calcium ([Ca^(2+) ]_i) is mainly regulated by mitochondriaand endo-plasmic reticula. This study was carried out to ascertain whether the elementary mechanismof the effects of etimicin (EM) and gentam...
关键词：ETIMICIN GENTAMICIN ca^(2+) homeostasis MITOCHONDRIA endoplasmic reticula 
Influence of piperacillin on pharmacokinetics of etimicin in healthy volunteers
《Acta Pharmacologica Sinica》2002年第4期90-94,共5页王海学 张莉蓉 马小超 马统勋 
AIM: To investigate the influence of piperacillin on the pharmacokinetics of etimicin. METHODS: Ten healthy male volunteers subjects were administered randomly with 200 mg of etimicin alone or in combination with 2000...
关键词：ETIMICIN PIPERACILLIN pharmacokine- tics microbiological techniques 
A randomized controlled clinical trial on etimicin, a new aminoglycoside antibiotic, versus netilmicin in the treatment of bacterial infections被引量：7
《Chinese Medical Journal》2000年第11期66-70,共5页赵彩芸 李家泰 侯杰 郭敏 张烨 陈亦芳 
To compare the efficacy and safety of two aminoglycoside antibiotics, etimicin and netilmicin, in the treatment of bacterial infections Methods A randomized, open label, controlled clinical trial was conducted for t...
关键词：ETIMICIN netilmicin randomized controlled    clinical trP 
The Effects of Etimicin and Gentamicin on Renal Endoplasmic Reticulum ^(45)Ca^(2+)-Uptake and Ca^(2+)-Mg^(2+)-ATPase Activity
《Journal of Chinese Pharmaceutical Sciences》1998年第3期45-48,共4页李忠东 洪文清 李培忠 
Objective: To study the effects of etimicin (EM) and gentamicin (GM) on renal endoplasmic reticulum 45 Ca 2+ uptake and Ca 2+ Mg 2+ ATPase activity. Methods: Using 45 Ca 2+ inc...
关键词：Etimicin (EM) Gentamicin (GM) Endoplasmic reticulum 45  Ca    2+    uptake Ca    2+    Mg    2+    ATPase 
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