The prevalence and distribution of aminoglycoside resistance genes  

作　　者：Yuan Zhang Ning Zhang Mengyu Wang Ming Luo Yao Peng Zhenpeng Li Jialiang Xu Meiling Ou Biao Kan Xu Li Xin Lu 

机构地区：[1]National Institute for Communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 102206,China [2]Beijing Technology and Business University,Beijing 102488,China [3]School of Public Health,Shandong University,Jinan 250012,China [4]Yulin Center for Disease Control and Prevention,Guangxi 537000,China

出　　处：《Biosafety and Health》2023年第1期14-20,共7页生物安全与健康（英文）

基　　金：the National Key Research and Development Program of China(2020YFE0205700,2022YFC2303900);the major projects of the National Natural Science Foundation of China(22193064);the Research Foundation for Youth Scholars of Beijing Technology and Business University(19008022271);the National Science and Technology Major Project(2018ZX10714002);the Science Foundation(2022SKLID303)of the State Key Laboratory of Infectious Disease Prevention and Control,China.

摘　　要：Choosing the appropriate antibiotics to treat bacterial infections has grown more challenging as a result of the emergence of antibiotic-resistant bacteria.Aminoglycosides,as broad-spectrum antibiotics,are increasingly being used clinically;however,for most effective employment of aminoglycosides,a comprehensive understanding of aminoglycoside resistance genes’prevalence and dissemination is required.Therefore,to better understand the global resistance status of aminoglycoside antibiotics and the prevalence of antibiotic-resistance genes(ARGs)in various bacterial species,this systematic review gathered relevant data from multiple studies.Two primary resistance mechanisms-aminoglycoside enzymatic modification and 16S rRNA methylation-were assessed,and the prevalence of the corresponding ARGs was described.The coexistence of aminoglycoside ARGs with other ARGs was also demonstrated,as was the relationship between aminoglycoside ARGs and resistant phenotypes.The lack of effective therapeutic agents to combat resistant pathogens presents a real threat to public health.The combination of aminoglycosides with other antibiotics may provide a novel treatment strategy.

关 键 词：AMINOGLYCOSIDE Aminoglycoside resistance Aminoglycoside resistance gene Aminoglycoside modifying enzyme 16S rRNA methylation enzyme 

分 类 号：R378[医药卫生—病原生物学]