INOSINE

作品数：42被引量：73H指数：5
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相关领域：医药卫生更多>>
相关作者：龚薇薇张红张礼和张亮仁杨振军更多>>
相关机构：青岛大学东北财经大学北京大学更多>>
相关期刊：《Chinese Herbal Medicines》《Journal of Animal Science and Biotechnology》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金更多>>
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Quantitative and Site-specific Analysis of Adenosine-to-inosine RNA Editing by Ligation-assisted qPCR
《Chemical Research in Chinese Universities》2025年第2期288-295,共8页TAO Wanbing GU Shuyi XIONG Jun YUAN Bifeng 
supported by the National Key R&D Program of China(No.2022YFC3400700);the National Natural Science Foundation of China(Nos.22074110,22277093,22207090);the Key Research and Development Project of Hubei Province,China(No.2023BCB094);the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University,China(Nos.ZNJC202208,ZLJC2022001).
RNA molecules undergo a variety of modifications,including inosine modification,also called adenosine-to-inosine(A-to-I)RNA editing,which is prevalent across all domains of life.To unravel the roles of A-to-I RNA edit...
关键词：A-to-I RNA editing INOSINE RNA modification Quantification Site-specific detection 
GLP-1RAs attenuated obesity and reversed leptin resistance partly via activating the microbiome-derived inosine/A2A pathway
《Acta Pharmaceutica Sinica B》2025年第2期1023-1038,共16页Chunyan Dong Bailing Zhou Binyan Zhao Ke Lin Yaomei Tian Rui Zhang Daoyuan Xie Siwen Wu Li Yang 
supported by the 1.3.5 Project for Disciplines of Excellence(No.ZYGD18007);West China Hospital,Sichuan University,the Natural Science Foundation Project of Sichuan Province(No.2022NSFSC1309,China);the National Natural Science Foundation of China(No.82203016).
Extensive evidence has demonstrated that glucagon-like peptide-1 receptor agonists(GLP-1RAs)can ameliorate obesity.Our previous studies revealed that(Ex-4)2-Fc,a long-acting GLP-1RA we developed,depends on the leptin ...
关键词：OBESITY GLP-1RAs Gut microbiota Metabolite Obesity-related inflammation Leptin resistance Macrophage-adipocyte A2A pathway 
CAR-T overdrive:harnessing inosine for metabolic rewiring and stemness induction
《Signal Transduction and Targeted Therapy》2024年第6期2347-2348,共2页MartíFarrera-Sal Michael Schmueck-Henneresse 
a grant(CONAN,16GW0328K)provided by the Federal Ministry of Education and Research(BMBF).
In a recent Cancer Cell publication,Klysz et al.investigated the impact of inosine(INO),a catabolic product of adenosine(Ado),on Chimeric Antigen Receptor(CAR)T-cell function,stemness,and exhaustion.They provided insi...
关键词：programming. CAR ADO 
Sequencing methods and functional decoding of mRNA modifications被引量：1
《Fundamental Research》2023年第5期738-748,共11页Kai Li Jinying Peng Chengqi Yi 
the Ministry of Science and Technology of China(2019YFA0110902,2019YFA0802201)。
More than 160 types of post-transcriptional RNA modifications have been reported;there is substantial variation in modification type,abundance,site,and function across species,tissues,and RNA type.The recent developme...
关键词：RNA modification N6 2′-O-dimethyladenosine(m6Am) N1-methyladenosine(m1A) 5-Methylcytosine(m5C) N6-methyladenosine(m6A) Pseudouridine(Ψ) Inosine(I) 
Sensitive determination of inosine RNA modification in single cell by chemical derivatization coupled with mass spectrometry analysis被引量：1
《Chinese Chemical Letters》2023年第10期98-101,共4页Wan-Bing Tao Neng-Bin Xie Qing-Yun Cheng Yu-Qi Feng Bi-Feng Yuan 
supported by the National Key R&D Program of China(Nos.2022YFA0806600,2022YFC3400700);the National Natural Science Foundation of China(Nos.22277093,22074110,21721005).
Inosine is a vital RNA modification across three kingdoms of life.It has been demonstrated that inosine plays important roles in modulation of the fate of RNAs.In the current study,we developed a highly sensitive meth...
关键词：INOSINE RNA modification CMCT DERIVATIZATION Mass spectrometry Single cell 
Ameliorative effect of Lacticaseibacillus rhamnosus Fmb14 from Chinese yogurt on hyperuricemia被引量：2
《Food Science and Human Wellness》2023年第4期1379-1390,共12页Hongyuan Zhao Xiaoyu Chen Fanqiang Meng Libang Zhou Xinyi Pang Zhaoxin Lu Yingjian Lu 
the National Natural Science Foundation of China(32072182).
Hyperuricemia is a critical threat to human health,and a high inosine diet can increase the prevalence of it.Lacticaseibacillus rhamnosus Fmb14 was isolated from traditional fermented Chinese yogurt,and its inosine de...
关键词：Lacticaseibacillus rhamnosus Fmb14 HYPERURICEMIA Inosine degradation Uric acid metabolism 
Inosine:A broad-spectrum anti-inflammatory against SARS-CoV-2 infection-induced acute lung injury via suppressing TBK1 phosphorylation
《Journal of Pharmaceutical Analysis》2023年第1期11-23,共13页Ningning Wang Entao Li Huifang Deng Lanxin Yue Lei Zhou Rina Su Baokun He Chengcai Lai Gaofu Li Yuwei Gao Wei Zhou Yue Gao 
from the Young Elite Scientists Sponsorship Program by CAST(Grant No.:2021-QNRC1-03);the National Key Research and Development Program of China(Grant No.:2020YFC0845400).
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-induced cytokine storms constitute the primary cause of coronavirus disease 19(COVID-19)progression,severity,criticality,and death.Glucocorticoid and anti-cy...
关键词：CYTOKINE stormInterleukin 6 (IL-6)InosineSARS-CoV-2TANK-binding kinase 1 (TBK1) 
6-Thioguanine incorporates into RNA and induces adenosine-to-inosine editing in acute lymphoblastic leukemia cells被引量：1
《Chinese Chemical Letters》2023年第1期539-543,共5页Xue-Jiao You Lin Li Tong-Tong Ji Neng-Bin Xie Bi-Feng Yuan Yu-Qi Feng 
supported by the National Natural Science Foundation of China(Nos.22074110,21635006,21721005)。
6-Thioguanine(6TG)is a widely used chemotherapeutic agent for the treatment of a variety of human diseases including acute lymphoblastic leukemia.After entry into cells,6TG is metabolically converted into 6-thioguanos...
关键词：6-THIOGUANINE RNA modification INOSINE LEUKEMIA Mass spectrometry 
Fire up the pyre:inosine thermogenic signaling for obesity therapy
《Signal Transduction and Targeted Therapy》2022年第12期4255-4256,共2页Nienke Willemsen Stefan Kotschi Alexander Bartelt 
S.K.was supported by the LMU Medical Faculty(FöFoLe);A.B.was supported by DFG and ERC grants.
In a recent study published in Nature,Niemann et al.may have discovered a metabolite signaling pathway that could pave the way to new weight loss drugs1(Fig.1).Obesity and its comorbidities are a major threat to publi...
关键词：SINE WEIGHT DRUGS 
Development of an eco-friendly and fast HPLC method for quantitative analysis of four nucleosides in Cordyceps and related products被引量：2
《Chinese Journal of Natural Medicines》2021年第12期954-960,共7页QIAN Zheng-Ming WU Zi HUANG Qi WANG Chuan-Xi TAN Guo-Yin LI Wen-Jia SUN Wan-Yang LV Gen-Pin GAO Hao 
supported by the National Natural Science Foundation of China (Nos.81925037, 82073976, and 31700013);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (No.2017BT01Y036);Guangdong Natural Science Funds for Distinguished Young Scholar(No.2021B1515020065);the Young Elite Scientists Sponsorship Program by the China Association of Chinese Medicine (No.QNRC2-B06);the Dongguan Academician Workstation Project (No.DGYSZ-2018-03)。
An eco-friendly and fast HPLC method was developed for the determination of adenosine, inosine, guanosine and uridine in Cordyceps and related products(fermented mycelia of Hirsutella sinensis and Paecilomyces hepiali...
关键词：ADENOSINE INOSINE GUANOSINE URIDINE CORDYCEPS 
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