CAR-T overdrive:harnessing inosine for metabolic rewiring and stemness induction  

作　　者：MartíFarrera-Sal Michael Schmueck-Henneresse 

机构地区：[1]Berlin Institute of Health(BIH)at Charité—Universitatsmedizin Berlin,BIH Center for Regenerative Therapies(BCRT),Experimental Immunotherapy,Augustenburger Platz 1,Berlin,Germany

出　　处：《Signal Transduction and Targeted Therapy》2024年第6期2347-2348,共2页信号转导与靶向治疗（英文）

基　　金：a grant(CONAN,16GW0328K)provided by the Federal Ministry of Education and Research(BMBF).

摘　　要：In a recent Cancer Cell publication,Klysz et al.investigated the impact of inosine(INO),a catabolic product of adenosine(Ado),on Chimeric Antigen Receptor(CAR)T-cell function,stemness,and exhaustion.They provided insights into T-cell exhaustion metabolic pathways and proposed mechanisms for overcoming it through metabolic reprogramming.

关 键 词：programming. CAR ADO 

分 类 号：R730.51[医药卫生—肿瘤]