DERIVATIZATION

作品数：109被引量：188H指数：6
导出分析报告
相关作者：温忆敏卢大胜汪国权刘俊亭王妍更多>>
相关机构：上海市疾病预防控制中心暨南大学中国药科大学中国医科大学更多>>
相关期刊：更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划上海市科学技术委员会资助项目中国博士后科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Cobalamin-dependent radical S-adenosyl-L-methionine protein functions with a partner to successively methylate tricyclic indole alkaloid for chuangxinmycin maturation and derivatization
《Science China Chemistry》2025年第1期308-316,共9页Sili Wang Jiancheng Huang Yanan Du Wei Huang Yufeng Xue Xiaokun Xu Guannan Zhong Yuanyuan Shi Bin Hong Xiaoying Bian Wen Liu 
supported in part by the National Key Research and Development Program of China(2022YFC2303100);the National Natural Science Foundation of China(32030002,22193070);the Shanghai Post-Doctoral Excellence Program(2022718)。
Cobalamin(Cbl)-dependent radical S-adenosyl-L-methionine(SAM)proteins constitute the largest collection of the radical SAM superfamily that has hundreds of thousands of individual members.Many of these proteins are in...
关键词：cbl-dependent radical SAM protein biosynthesis chuangxinmycin stereoselective methylation 
Vacuum promoted on-tissue derivatization strategy:Unravelling spatial distribution of glycerides on tissue
《Chinese Chemical Letters》2024年第12期475-481,共7页Yu-Qi Cao Ying-Jie Lu Li Zhang Jing Zhang Yin-Long Guo 
supported by the National Key R&D Program of China(No.2021YFF0701900);the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0610000);Shanghai Science and Technology Innovation Action Plan(No.21142200800);the Program of EnShi TuJia&Miao Autonomous Prefecture Bureau of Scientific&Technological Affairs。
Matrix-assisted laser desorption ionization-mass spectrometry imaging(MALDI-MSI)has shown its capability in visualizing the spatial distribution of various kinds of endogenous metabolites.Nevertheless,high quality mas...
关键词：Mass spectrometry imaging On-tissue derivatization GLYCERIDES Alzheimer’s disease 
Study on Derivatization and Biological Activity of Natural Product Daidzein
《Chemical Research in Chinese Universities》2024年第6期1256-1265,共10页LUO Zeping PAN Liwei 
supported by the 2023 Guangxi Zhuang Autonomous Region New Engineering,New Medical,New Agricultural,and New Humanities Research and Practice Project,China(No.XYK202319);the Project of Guangxi Collaborative Innovation Center of Modern Sericulture and Silk,China(No.2022GXCSSC10).
A new class of Daidzein derivatives were developed,and their protective effects on neuronal cells and their mechanisms were examined.The protective effects of Daidzein derivatives against oxygen and glucose deprivatio...
关键词：Daidzein derivatization Neuronal cell Protective effect 
Analysis of Fatty Acid in Biological Samples Using Liquid Chromatography–Quadrupole-Orbitrap Mass Spectrometry Under Parallel Reaction Monitoring Mode被引量：1
《Journal of Analysis and Testing》2024年第2期210-217,共8页Jingxuan Yang Wenjun Guo Xiaohang Xu Liang Zhao Yajuan Xu Yang Wang 
supported by the National Natural Science Foundation of China(82104366);the Department of Science and Technology of Jilin Province(20210101426JC and 20220505047ZP);the Changchun University of Chinese Medicine(202326)。
Fatty acids(FAs)are an important class of functional small molecules and participate in a variety of life biological processes.This experiment proposed a liquid chromatography–quadrupole-Qrbitrap mass spectrometry(LC...
关键词：Fatty acid DERIVATIZATION LC-Q-Orbitrap MS Parallel reaction monitoring Biological sample 
Utilization of hydralazine as a reactive matrix for enhanced detection and on-MALDI-target derivatization of saccharides
《Chinese Chemical Letters》2024年第5期386-391,共6页Dan Ouyang Huan Huang Yanting He Jiajing Chen Jiali Lin Zhuling Chen Zongwei Cai Zian Lin 
supported by a grant from the National Natural Science Foundation of China(Nos.22274021,21974021 and 22036001);the Natural Science Foundation of Fujian Province(No.2022J01535);the Major Project of Science and Technology of Fujian Province(No.2020HZ06006)。
Saccharides are a sort of ubiquitous and vital molecules within the whole life.However,the application of saccharides analysis with matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)is restricted ...
关键词：HYDRALAZINE Reactive matrix On-MALDI-target derivatization Saccharides 
Chemical derivatization strategies for enhancing the HPLC analytical performance of natural active triterpenoids
《Journal of Pharmaceutical Analysis》2024年第3期295-307,共13页Xiao-Feng Huang Ying Xue Li Yong Tian-Tian Wang Pei Luo Lin-Sen Qing 
Sichuan Science and Technology Program(Grant No.:2022ZYD0026);Biological Resources Program,Chinese Academy of Sciences(Grant No.:KFJ-BRP-008-007);the Macao Science and Technology Development Fund(Grant No.:0028/2019/AGJ).
Triterpenoids widely exist in nature,displaying a variety of pharmacological activities.Determining triterpenoids in different matrices,especially in biological samples holds great significance.High-performance liquid...
关键词：TRITERPENOID HPLC DERIVATIZATION Quantification 
Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin:Creation of an unnatural analogue with improved anticancer properties
《Acta Pharmaceutica Sinica B》2024年第1期421-432,共12页Dexiu Yan Jemma Arakelyan Teng Wan Ritvik Raina Tsz Ki Chan Dohyun Ahn Vladimir Kushnarev Tsz Kiu Cheung Ho Ching Chan Inseo Choi Pui Yi Ho Feijun Hu Yujeong Kim Hill Lam Lau Ying Lo Law Chi Seng Leung Chun Yin Tong Kai Kap Wong Wing Lam Yim Nikolay S.Karnaukhov Richard Y.C.Kong Maria V.Babak Yudai Matsuda 
This work was performed for the iGEM 2021 Competition,and the financial support received from the Department of Chemistry,City University of Hong Kong,is greatly appreciated.We also thank Prof.Katsuya Gomi(Tohoku University)and Profs.Katsuhiko Kitamoto and Jun-ichi Maruyama(The University of Tokyo)for providing the expression vectors and the fungal strain.We are grateful to Dr.Man-Kit Tse(City University of Hong Kong)and Dr.Shek-Man Yiu(City University of Hong Kong)for their assistance with NMR spectra acquisition and X-ray diffraction data collection and analysis,respectively.This work was supported in part by an Early Career Scheme grant from the Research Grants Council(RGC)of Hong Kong(Project No.21300219(Y.M));M.V.B acknowledges support from the City University of Hong Kong(Project No.9610518).
A biosynthetic gene cluster for the bioactive fungal sesterterpenoids variecolin(1)and variecolactone(2)was identified in Aspergillus aculeatus ATCC 16872.Heterologous production of 1 and 2 was achieved in Aspergillus...
关键词：Animal studies Anticancer properties BIOSYNTHESIS Natural products Sesterterpenoids Synthetic biology Terpene synthases Variecolin 
DMMIC derivatization-assisted liquid chromatography-mass spectrometry method for metabolite profiling of the glutathione anabolic pathway in esophageal cancer tissues and cells被引量：1
《Journal of Pharmaceutical Analysis》2023年第11期1365-1373,共9页Li Liu Yu-Han Lu Min-Dan Wang Qun-Fei Zhao Xiu-Ping Chen Hang Yin Chen-Guo Feng Fang Zhang 
We thank the Shanghai Municipal Committee of Science and Technology(Grant Nos.:20XD1423400,23ZR1460900 and 20DZ2201100);Shanghai Municipal Health Commission/Shanghai Municipal Administration of Traditional Chinese Medicine(Grant No.:ZY(2021e2023)-0501);Shanghai Science and Technology Development Fund from Central Leading Local Government(Grant No.:YDZX20223100001004);National Natural Science Foundation of China(Grant No.:21672249);Expenditure Budget Program of Shanghai University of Traditional Chinese Medicine(Grant Nos.:2020LK051,and 2021LK001).
In this work,a new pyrylium derivatization-assisted liquid chromatography-mass spectrometry(LC-MS)method was developed for metabolite profiling of the glutathione anabolic pathway(GAP)in cancer tissues and cells.The p...
关键词：Glutathione anabolic pathway Metabolite profiling DMMIC derivatization LC-MS Esophageal squamous cell carcinoma p-Hydroxycinnamaldehyde KYSE-150cell 
Polarity-regulated derivatization-assisted LC-MS method for amino-containing metabolites profiling in gastric cancer
《Journal of Pharmaceutical Analysis》2023年第11期1353-1364,共12页Jie Han Shilin Gong Xiqing Bian Yun Qian Guilan Wang Na Li Jian-Lin Wu 
supported by the Science and Technology Development Fund,Macao SAR(Grant No.:0025/2021/A1);funded by Natural Science Foundation of Shenzhen(Grant No.:JCYJ20190808115003699);Major Medical Projects in Zhongshan(Grant No.:2017B1003).
Amino-containing compounds,including amino acids,aliphatic amines,aromatic amines,small peptides and catecholamines,are involved in various biological processes and play vital roles in multiple metabolic pathways.Prev...
关键词：Polarity-regulated derivatization Amino-containing metabolites Gastric cancer Liquid chromatography-mass spectrometry 
Sensitive determination of inosine RNA modification in single cell by chemical derivatization coupled with mass spectrometry analysis被引量：1
《Chinese Chemical Letters》2023年第10期98-101,共4页Wan-Bing Tao Neng-Bin Xie Qing-Yun Cheng Yu-Qi Feng Bi-Feng Yuan 
supported by the National Key R&D Program of China(Nos.2022YFA0806600,2022YFC3400700);the National Natural Science Foundation of China(Nos.22277093,22074110,21721005).
Inosine is a vital RNA modification across three kingdoms of life.It has been demonstrated that inosine plays important roles in modulation of the fate of RNAs.In the current study,we developed a highly sensitive meth...
关键词：INOSINE RNA modification CMCT DERIVATIZATION Mass spectrometry Single cell 
全选清除导出
共11页<12345678910>
检索报告 对象比较 聚类工具 使用帮助 返回顶部